Clinical Pharmacology Podcast with Nathan Teuscher

In this episode we’re going to define Volume of Distribution, look at the different types of Volume of Distribution parameters, talk about how we actually calculate it, examine what drives its value, and—most importantly—discuss why it matters for the decisions we make every day in drug development.
Links discussed in the show:

Volume of Distribution
Volume of Distribution in Drug Design
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This episode is an interview with Michael Stackhouse, the Chief Innovation Officer at Atorus Research. We discussed a variety of topics such as modern data science tools, why regulatory agencies want to get rid of SAS transport files in favor of Dataset JSON file formats, and how AI is being used in data programming and data science.
Links discussed in the show:
Connect with Mike on LinkedIn
Learn more about Atorus Research on their website
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This episode is an interview with Dr. Wouter Vaes, the Chief Science Officer of Peregrion. We discuss how accelerator mass spectrometry is being used in early clinical development for drug metabolism and pharmacokinetics. We discuss using this technology to support development of oncology agents, determining absolute bioavailability without IV toxicology work, and more.

Links discussed in the show:
You can contact Wouter by email: [email protected]
Connect with Peregrion on LinkedIn or their website
Symposium on microtracer studies
FDA guidance on safety testing of drug metabolites
White paper on human ADME data
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This episode is an interview with Aruna Dhontabhaktuni, Founder and CEO of RegKey, a regulatory intelligence platform that uses AI. The discussion touches on how companies can leverage large language model AI tools to accelerate regulatory strategy work.

Links discussed in the show:
You can contact Aruna by email: [email protected]
Visit the RegKey website
Connect with Aruna on LinkedIn
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This episode is a collection of my thoughts on model-informed drug development and where different modeling modalities fit into the development schedule. These are just my opinions and each development program is different.
Links discussed in the show:
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All Rights Reserved