OncoPharm

This week's pod covers some brief updates comparing the timelines of the FDA approvals for daraxonrasib vs. enfortuamb vedodin + pembrolizumab, before devoting the rest of the time to the new approval of gedatolisib, a PIK3CA inhibitor, with fulvestrant and maybe palbociclib if you feel like it for metastatic breast cancer in the 2nd line. Oh, in patients WITHOUT PIK3CA mutations.

Download the Oncology Learning Companion: https://www.kelleycpharmd.com/learning-oncology-companion-oncopharm

Did lenalidomide maintenance in multiple myeloma just get limited to 2 years?

Endurance Trial, Part 2: https://www.nejm.org/doi/full/10.1056/NEJMoa2600157

Learning Oncology Companion: https://www.kelleycpharmd.com/learning-oncology-companion-oncopharm

We are a decade into the CAR-T era, and what to long term outcomes look like with tisagenlecleucel in B-cell lymphomas?

Orca-T is approved, an allogenic cocktail of stem & progenitor cells, Tregs, and then conventional T-cells. Neato.

Polar-Go! or PolARGo?

And the concept of T-cell "stemless" is intriguing with possibilities: DOI: 10.1056/NEJMcibr2601002
Learning Oncology Companion:https://www.kelleycpharmd.com/learning-oncology-companion-oncopharm

This week we discuss a new approval for pabociclib in HER2-positive disease based on the PATINA trial as well as the use of sacituzumab govitecan + pembrolizumab in TNBC, recently approved based on the ASCENT04/KEYNOTED19 trial.

And the concept of T-cell "stemless" is intriguing with possibilities: DOI: 10.1056/NEJMcibr2601002
Learning Oncology Companion: https://www.kelleycpharmd.com/learning-oncology-companion-oncopharm

Lots of bite-size updates in this episode.

Capitello-281: capivasertib + abiraterone (+ prednisone + ADT)
Adjuvant Belzutifan + Pemroblizumab is FDA approved
Durvalumab approved with BCG for non-muscle invasive bladder cancer
Insightful commentary: https://doi.org/10.1200/JCO-25-02670
Talquetamab + Durvaluamb - a new safety signal?

Learning Oncology Companion: https://www.kelleycpharmd.com/learning-oncology-companion-oncopharm