Progress, Potential, and Possibilities Podcast / Show

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Dr. Samir Khleif, MD - CEO, Georgiamune Inc. - Reprogramming Immune Responses
Send us a textDr. Samir Khleif, MD is CEO of Georgiamune ( https://www.georgiamune.com/team ), a private, science and discovery clinical stage immunotherapeutic biotechnology company focused on reprogramming immune signaling pathways to redirect the immune system to fight diseases. Dr. Khleif is a pioneer in the field of immunotherapy. He is a medical oncologist, immunologist, innovator, and entrepreneur, as well as a transformational executive in health care and biomedical research.Prior to becoming CEO of Georgiamune, Dr. Khleif served in different academic and leadership positions. He was a National Cancer Institute (NCI)/National Institutes of Health (NIH) scientist and Chief of the NCI Cancer Vaccine Section, where he led the development of pioneering immune-oncology and cancer vaccines into clinical trials. As a national and international academic leader, and detailed by the US government, he served as the founding director and CEO of the King Hussein Cancer Center ( https://www.khcc.jo/en ) in Amman, Jordan, where he led the development of the largest cancer center in the MENA region. He also served as the director of the Georgia Cancer Center, the state cancer center, at Augusta University. He is currently a biomedical scholar and holds a professorship at Georgetown University Medical School.Dr. Khleif also served as a Special Assistant to the Commissioner of the FDA, leading the FDA's Critical Path Initiative for Oncology. He is a member of the board of directors of Ayala Pharmaceuticals and Emerald Biopharmaceutics, and served as a member of the scientific advisory board of more than 20 biotechnology and pharmaceutical companies.Dr. Khleif is an international KOL in immunology and immunotherapy. He has served on many national committees, including the Scientific Advisory Board of the Biden Cancer Initiative, as chair of the Immunotherapy Committee for NRG, and as a member of the NCI Cooperative Group. He currently serves as an advisor for the Parker Institute for Cancer Immunotherapy. Dr. Khleif is an editor of three books, the author of hundreds of peer-reviewed scientific research articles, and a prolific inventor with more than 150 patents issued or pending in the field of immunology and immunotherapy.Dr. Khleif received his medical degree at the University of Jordan, Amman Jordan. He completed his residency in Internal Medicine at the Medical College of Ohio and his fellowship in Medical Oncology at the National Cancer Institute (NCI) in Bethesda, Maryland.#SamirKhleif #Georgiamune #Immunotherapy #KingHusseinCancerCenter #CriticalPathInitiative #FDA #Tregs #RegulatoryTCells #Cancer #Oncology #CheckpointInhibitors #ImmuneEscapeMechanisms #DualFunctioningAntibody #Autoimmune #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show
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51:11
Dr. Sui Huang, MD, PhD - Professor, Institute for Systems Biology (ISB) - Complex Systems Approaches For Biomedical Research
Send us a textDr. Sui Huang, MD, PhD is a Professor at the Institute for Systems Biology ( ISB - https://isbscience.org/people/sui-huang-md-phd/?tab=biography ) where his lab is focused on studying how gene regulatory networks control gene activity to create stable cellular states, such as different cell types, and how these states transition into different lineages in both healthy and diseased conditions.Dr. Huang is a molecular and cell biologist with a strong background in theoretical biology and has devoted much of his research to understanding the very phenomenon of cancer from a complex systems perspective. Before joining the ISB in fall 2011, Dr. Huang held faculty positions at the University of Calgary (Institute of Biocomplexity and Informatics), where he helped establish biocomplexity as a discipline in research and teaching, and at Harvard Medical School (Children’s Hospital) where he obtained first experimental evidence for the existence of high-dimensional attractors in mammalian gene regulatory networks.Dr. Huang grew up in Geneva and Zurich. He received his MD degree from the University of Zurich and obtained thereafter, as the first recipient of the PhD-Program-for-Physicians Award of the Swiss National Science Foundation, his PhD in molecular biology and physical chemistry for work on interferons. As a postdoctoral fellow at Children’s Hospital Boston he investigated tumor angiogenesis and cell growth control. In that period he also studied dynamical systems through his affiliation with the New England Complex Systems Institute.Important Episode Link - "The end of the genetic paradigm of cancer" - PLOS Biologyhttps://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003052#SuiHuang #InstituteForSystemsBiology #Interferon #Angiogenesis #AttractorStates #Epigenetics #Cancer #Oncology #TumorMicroenvironment #DonaldIngber #ConradWaddington #Organogenesis #Morphogenesis #LeeHood #BeatriceMintz #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show
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1:05:52
Mark McDonough - CEO, Cyrex Labs - Early Detection & Monitoring Of Complex Immune Conditions
Send us a textMark McDonough is the CEO of Cyrex Labs ( https://www.cyrexlabs.com/ ), a clinical immunology laboratory specializing in functional immunology and autoimmunity testing. Cyrex offers multi-tissue antibody testing for the early detection and monitoring of today’s complex autoimmune conditions and develops innovative arrays through continuous collaboration with leading experts in medical research and clinical practice.Mark is a global technology business executive with 30 years of experience, and his personal mission is to impact change in the field of healthcare in a compassionate yet resolute manner, leading by example.Prior to Cyrex, Mark served in several private and public company CEO roles including PierianDx and CombiMatrix, a publicly held molecular diagnostics company performing DNA-based testing services for reproductive health, oncology, and developmental disorders.Earlier in his career, Mark served in various sales leadership roles at high growth diagnostic companies to include Ventana Medical Systems (acquired by Roche) and US LABS (acquired by LabCorp). Mark is married with three children and is a proud former Naval Officer having served as a Navigator and Communications Officer on the USS FLETCHER (DD 992).#MarkMcDonough #CyrexLabs #ClinicalImmunology #FunctionalImmunology #Autoimmunity #AristoVojdani #FoodAssociatedAutoimmunities #Neuroimmunity #BrainGutConnection #LifestyleMedicine #Antigenic #Inflammation #MolecularMimicry #ImmuneReactivity #PathogenAssociatedImmuneReactivity #MultipleChemicalSensitivities #MicrobialTransglutaminase #CeliacDisease #NonCeliacGlutenSensitivity #CrohnsDisease #Neuroautoimmunity #Neurodegeneration #BloodBrainBarrier #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show
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37:19
Dr. Michael Osterholm, PhD, MPH - Director, Center for Infectious Disease Research & Policy (CIDRAP) - University of Minnesota - Emerging Infectious Disease Preparedness And Response
Send us a textDr. Michael Osterholm, PhD, MPH ( https://www.cidrap.umn.edu/michael-t-osterholm-phd-mph ) is Regents Professor, McKnight Presidential Endowed Chair in Public Health, the Director of the Center for Infectious Disease Research and Policy (CIDRAP), Distinguished Teaching Professor in the Division of Environmental Health Sciences, School of Public Health, a professor in the Technological Leadership Institute, College of Science and Engineering, and an adjunct professor in the Medical School, all at the University of Minnesota. Dr. Osterholm is also a member of the National Academy of Medicine (NAM) and the Council of Foreign Relations. In June 2005 Dr. Osterholm was appointed by Michael Leavitt, Secretary of the Department of Health and Human Services (HHS), to the newly established National Science Advisory Board on Biosecurity. In July 2008, he was named to the University of Minnesota Academic Health Center’s Academy of Excellence in Health Research. In October 2008, he was appointed to the World Economic Forum Working Group on Pandemics.Dr. Osterholm is an internationally recognized expert in infectious disease epidemiology and is the author of more than 300 papers and abstracts, including 20 book chapters, and New York Times best-selling 2017 book, Deadliest Enemy: Our War Against Killer Germs ( https://www.amazon.com/Deadliest-Enemy-Against-Killer-Germs/dp/0316343692 ).Dr. Osterholm's new book will be coming out in September, 2025, entitled The Big One: How We Must Prepare for Future Deadly Pandemics ( https://www.amazon.com/Big-One-Prepare-World-Altering-Pandemics-ebook/dp/B0C1G5BHG3 ).Dr. Osterholm has received numerous honors for his work, including an honorary doctorate from Luther College; the Pump Handle Award, CSTE; the Charles C. Shepard Science Award, CDC; the Harvey W. Wiley Medal, FDA; the Squibb Award, IDSA; Distinguished University Teaching Professor, Environmental Health Sciences, School of Public Health, UMN; and the Wade Hampton Frost Leadership Award, American Public Health Association. He also has been the recipient of six major research awards from the NIH and the CDC.Dr. Osterholm received his PhD and MS in Environmental Health, and MPH in Epidemiology, from the University of Minnesota. #MichaelOsterholm #InfectiousDisease #CenterForInfectiousDiseaseResearchAndPolicy #CIDRAP #PublicHealth #AntimicrobialStewardship #VaccineIntegrityProject #AntimicrobialResistance #MinnesotaDepartmentOfHealth #Epidemiologist #ToxicShockSyndrome #FoodborneIllness #Hepatitis #Biodefense #Countermeasures #ChronicWastingDisease #Preparedness #Policy #Surveillance #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #Podcasting #ViralPodcast #STEM #Innovation #Science #Technology #ResearchSupport the show
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59:13
Dr. Manfred Stapff, MD, PhD - Founder, Candid Advisory - Real-World Evidence Unveiled
Send us a textDr. Manfred Stapff, MD, PhD is a physician and pharmaceutical industry leader with over 30 years of experience in internal medicine, clinical research, and drug development, who has worked across a range of therapeutic areas including NASH, CV, CNS, respiratory, oncology, GI, anti-infective, and orphan diseases.Dr. Stapff has held senior roles at Merck & Co., Forest Laboratories (now Allergan), and LG Chem (CMO / COO), specializing in clinical development, regulatory affairs, and global medical operations. As Chief Medical Officer at TriNetX, he helped build the worldʼs largest real-world data (RWD) research network. Dr. Stapff’s expertise spans clinical trials, drug development, regulatory affairs, quality management, and real-world studies.As the founder of Candid Advisory (https://candid-advisory.com/), Dr. Stapff helps organizations leverage real-world data and AI to improve healthcare decision-making and regulatory strategies. Dr. Stapff’s new book, Real-World Evidence Unveiled: Navigating the Maze of Modern Misinformation ( https://www.amazon.com/Real-World-Evidence-Unveiled-Navigating-Misinformation-ebook/dp/B0F6DWR6MY?ref_=ast_author_mpb ), explores how misinformation shapes science, media, and public health and how we can separate fact from fiction.#RealWorldEvidence #ManfredStapff #ClinicalTrials #RegulatoryAffairs #RealWorldData #DrugRepurposing #RWE #ArtificialIntelligence #FakeNews #MediaBias #Misinformation #ProgressPotentialAndPossibilities #IraPastor #Podcast #Podcaster #ViralPodcast #STEM #Innovation #Technology #Science #ResearchSupport the show
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