The DeSci Podcast

• Knowledge as a Public Good: Joshua Bate on DeSciWorld's Proof of Knowledge Protocol

  Welcome to another episode of the DeSci Podcast! Today, we’re excited to host Joshua Bate, Founder of DeSciWorld. DeSciWorld is a community-driven initiative dedicated to facilitating the onboarding of individuals into the Decentralized Science (DeSci) space. It provides users with the tools to view, engage with, and understand everything happening in the world of decentralized science. In this episode, Joshua shares the vision behind DeSciWorld and its role as a global hub for the decentralized science community. We touch on Joshua's frank thoughts on the DeSci movement and how open discussion and unadultered knowledge transfer, alongside powerful incentives, are necessary to grow the space. We also discuss the “Proof of Knowledge protocol”, DeSciWorld's upcoming technical product where users can upload data and receive incentives whenever their contributions are utilized. Joshua addresses concerns about spam and low-quality dataset submissions, as well as potential technical approaches to ensure that the data used to train AI remains high-quality and reliable. DeSci World: https://desci.world/ SynapseDAO: https://synapse-dao.webflow.io/ Feel free to navigate through any of the topics discussed in the podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 1:28 Overview of DeSci World 04:24 About “Proof of Knowledge” protocol 7:07 Ensuring high-quality datasets 14:04 Common misconceptions about DeSci 16:28 How incentives can drive DeSci adoption in Academia 20:10 Underappreciated aspects of Decentralized Science 22:10 Recommendations for getting started in DeSci 24:23 Competition vs. collaboration in the Web3 space 25:48 Scope of biotech 30:59 The future of of Decentralized Science 33:55 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea: https://twitter.com/lealeata Joshua: https://twitter.com/jb87ua ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

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• Democratizing Early-Stage Research Funding: Inside Catalyst, Molecule’s DeSci Funding Machine

  In this episode, we're diving deep into Molecule's Catalyst, an incentive-driven funding system for basic research. We begin by exploring the significant challenges posed by traditional funding models. We then touch on the "Valley of Death"—a critical juncture where many groundbreaking ideas fail often due to a lack of financial support. We discuss why early-stage research often struggles to gain traction and the barriers that prevent innovative ideas from reaching their full potential. Catalyst is at the forefront of addressing these issues with its decentralized approach. By realigning incentives and democratizing access to research funding, Catalyst fosters collaboration and makes science more inclusive and inviting. We also explore the role of IP tokens (IPTs) in decentralized science and how they democratize access to and control over scientific advancements. Additionally, we explain Catalyst’s bonding curve, which features dynamic pricing that rewards early backers with lower token prices and ensures fair pricing as more tokens are minted. This system not only incentivizes early support but also maintains a transparent and equitable funding environment. Tune in to discover the potential of decentralized funding in science and how you can get involved. Whether you're a researcher, an investor, or simply curious about the future of science, this episode is packed with insights you won't want to miss. ___ ⭐ Timestamps: 0:00 Intro 18:04 Challenges of traditional funding models 19:47 The valley of death; how it impacts research 24:30 Difficulty in getting involved in early-stage ideas 31:20 Using IP as a tool to realign incentives 35:01 Why IP is the ideal use case for bringing ideas on-chain 42:05 Decentralized funding in science 48:44 Introduction to Catalyst 55:26 How Catalyst works 59:36 Catalyst bonding curve explained 1:03:22 The negotiation period in Catalyst fundraising 1:09:22 Final remarks ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Jillian: https://twitter.com/JillianCasalini Benji: https://twitter.com/benjileibo Kevin: https://www.linkedin.com/in/kevin-noessler Learn more about Catalyst here: https://catalyst.molecule.xyz/ ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

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• Revolutionizing Drug Development for Rare Diseases Through AI | Alok Tayi

  In this episode, we have the pleasure of hosting Alok Tayi, the co-founder of Vibe Bio.Vibe Bio is a life science company dedicated to investing in biotech firms, with a special focus on rare and overlooked diseases. In this episode, Alok shares his personal story of how medical conditions in his family led to the creation of Vibe Bio, and how the company aims to identify diseases with unmet needs, leveraging AI to find medicines with the highest chances of providing cures. We discuss the complexities of drug development, the advantages of DAOs as an organizational structure and common misconceptions within the Biopharma industry. Alok also shares his insights on the transformative role of AI in drug discovery, discussing its utilization, the methods used for training AI models, the issue of AI bias, and the current limitations and challenges faced in leveraging AI to advance drug development. Feel free to navigate through any of the topics discussed in the podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 01:51 What led you to create Vibe 02:52 Diseases Vibe Focuses On 04:37 Complexities in Drug Development 7:49 Advantages of DAOs 12:00 Misconceptions in Academia & the Private Sector 16:53 Areas you’re willing to explore with more funding. 23:59 Utilizing AI tools in Drug Discovery 28:50 Bias in AI 32:54 AI Training Methods 36:58 Limits of AI in Drug Discovery 39:56 Implicit Knowledge in Drug Development 49:30 Outro ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea: https://twitter.com/lealeata Alok: https://twitter.com/aloktayi Learn more about Vibe Bio here: https://vibebio.com/ ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

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• Decentralizing Healthcare Data Management: Hippocrat's Vision for Data Sovereignty

  Welcome to another episode of the DeSci Podcast. Today, we're joined by Justin, Head of Growth at Hippocrat, a collaborative healthcare data protocol that aims to transform healthcare by empowering individuals to take control of their health data through blockchain and zero-knowledge proof technologies. In this episode, we discuss the importance of data sovereignty, exploring how Hippocrat's innovative approach ensures secure and private data management, enabling safe and transparent data sharing with healthcare providers. Justin emphasizes the need for decentralized data provision in healthcare, stressing that shifting from centralized to decentralized data management addresses the longstanding issue of individuals lack of control over their health data, which in turn advances personalized healthcare and research. We also explore Hippocrat's collaboration with Research HUB, aimed at identifying potential populations and regions where Hippocrat's telemedicine application, ‘Hippodoc’, could be effectively deployed to bridge healthcare accessibility gaps. Feel free to navigate through any of the topics discussed in the podcast using the timestamps below. ___ ⭐ Timestamps: 0:00 Intro 1:28 About Hippocrat 2:37 Why data sovereignty is important 7:55 The inspiration behind Hippocrat 11:48 Moving from Web 2 to Web 3 healthcare 13:39 How Hippocrat improves Data security 22:27 $HPO token utility and upcoming airdrop 26:58 Collaboration with Research HUB 38:25 How the Hippodoc app works 41:27 Hippocrat role in the DeSci space 45:30 Hippocrat in 10 years 49:18 How to get involved ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Ella McCarthy-Page: https://twitter.com/EMcCarthyPage Justin Kim: (email: [email protected] / telegram: just_in_1) Special Airdrop for DeSci Podcast listeners: https://gleam.io/cLiQO/100-hippocrat-x-desci-podcast-giveaway Learn more about Hippocrat here: https://link3.to/hippocrat ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

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• Revolutionizing Research and Innovation Through Blockchain Technology

  In this episode we're joined by Dr. Sönke Bartling, Founder of Blockchain for Science, an initiative that aims to open up science and knowledge creation through web3. In this episode, we explore Decentralized Science (DeSci) and its potential to revolutionize research, publishing, and innovation! We dive deep into how blockchain technology can transform scholarly publishing by making it more transparent, efficient, and trustworthy. We also discuss how DeSci can address funding inequality by supporting both high-profile topics, such as longevity research, and smaller yet vital fields. This, in turn, enables DeSci to promote diversity in research and unlock breakthroughs in overlooked areas. We further discuss how DeSci can revolutionize the peer review process and explore the future of patents in a DeSci landscape, where research is incentivized without hindering collaboration, and how this can lead to more innovative scientific discoveries. Feel free to navigate through the various topics covered in the Podcast using the timestamps provided below. ___ ⭐ Timestamps: 0:00 Intro 1:46 Blockchains in the Future of Science and Research 4:25 Blockchain Adoption in Publishing 5:45 Underappreciated Aspects of DeSci 12:06 Radical Guidelines for Web3 17:19 Transitioning more Scientists to DeSci 25:26 What limits Institutional Change with Technology 30:22 Incentivising Foolproof DeSci 33:12 Plausibility and Reproducibility in Peer Review 36:16 Standards for Peer Review 39:14 DeSci for Publishing 40:25 The Private Sector and Academia 43:59 Non-monopolizing Patents with Web3 46:36 Further Questions ____ If you prefer listening to podcasts on audio apps, feel free to search for "The DeSci Podcast" on Spotify, Google Podcasts & Apple Podcasts. You'll also find all links to the podcast apps below. If you want to join us on the show as a speaker or have guest ideas, please shoot us an mail at [email protected] Special thanks to Lea Degen: https://twitter.com/lealeata Dr. Sönke Bartling: https://twitter.com/soenkeba ____ Let's connect: Website: https://bit.ly/3d6nh2C X: https://twitter.com/Molecule_dao Discord: https://discord.com/invite/moleculedao

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