304 episodes
Oh, It’s Autism, Mary H.K. Choi Learned at 43. Okay, She Thought, That Explains a Lot.
17/08/2026 | 1h 7 mins.Mary H.K. Choi compares living with her brain to just not understanding the operating system on a computer. She didn’t know if this was a result of trauma and neglect in her childhood, the experience of being parentified as a child, grief after the death of her father, or what. So she spent decades of effort and piles of dollars to figure it out. She did cognitive behavioral therapy, internal family systems therapy, “heroic doses of psilocybin under the watchful gaze of a shaman”, and anything else she could try. Finally, under the burnout and fear from covid, her functionality began to fall apart and she looked into the possibility of autism spectrum disorder as a possible culprit. And ding ding ding goes the slot machine, first a self-diagnosis from online resources and then a confirmed clinical diagnosis. Looking back now, she sees some of the clues, including a lack of empathy for others and the act of “performing competency”, that make more sense now. Mary offers insight on the long path to figuring out one’s mind and what she’s doing now that she has some answers.
Thank you to all our listeners who support the show as monthly members of Maximum Fun.
Check out our I’m Glad You’re Here and Depresh Mode merchandise at the brand new merch website MaxFunStore.com!
Hey, remember, you’re part of Depresh Mode and we want to hear what you want to hear about. What guests and issues would you like to have covered in a future episode? Write us at depreshmode@maximumfun.org.
Depresh Mode is on BlueSky, Instagram, Substack, and you can join our Preshies Facebook group.
Help is available right away.
The National Suicide Prevention Lifeline: 988 or 1-800-273-8255, 1-800-273-TALK
Crisis Text Line: Text HOME to 741741.
International suicide hotline numbers available here: https://www.opencounseling.com/suicide-hotlines
Help support this show and unlock bonus content! Become a member at https://maximumfun.org/joindepreshMargaret Glaspy Ends Her Instagram Addiction and Sings From Her Original Thought
10/08/2026 | 1h 2 mins.Margaret Glaspy compares the experience she was having on Instagram to being lightly punched in the gut, over and over, for a very long time. Like it’s not like being hit hard, just a little tap of something negative with each update you read, each comparison made, each distancing away from actual humanity and toward the simulated reality the platform presents. So she quit social media. Which was hard because it was an actual addiction. And then she wrote and recorded her new album, I Am Both, which just came out. It’s a remarkable work as Margaret leaned on her own mind, her own thoughts and memories and experiences. The California-raised, Brooklyn-based musician was inspired by the clear voice and perspective of heroes like Bob Dylan, Joni Mitchell, and John Steinbeck. It’s a candid interview that just might inspire you to make a big change of your own.
Thank you to all our listeners who support the show as monthly members of Maximum Fun.
Check out our I’m Glad You’re Here and Depresh Mode merchandise at the brand new merch website MaxFunStore.com!
Hey, remember, you’re part of Depresh Mode and we want to hear what you want to hear about. What guests and issues would you like to have covered in a future episode? Write us at depreshmode@maximumfun.org.
Depresh Mode is on BlueSky, Instagram, Substack, and you can join our Preshies Facebook group.
Help is available right away.
The National Suicide Prevention Lifeline: 988 or 1-800-273-8255, 1-800-273-TALK
Crisis Text Line: Text HOME to 741741.
International suicide hotline numbers available here: https://www.opencounseling.com/suicide-hotlines
Help support this show and unlock bonus content! Become a member at https://maximumfun.org/joindepreshDepression, Loneliness, and Memory Problems Are Worse In Middle Age, But Only in America
03/08/2026 | 49 mins.For most of the world, the advent of middle age does not make depression, loneliness, and memory issues more of a problem than earlier in life. In some countries, things actually get better. The only nation on earth where it all gets worse is right here in the USA. Arizona State University psychologist Frank Infurna has been researching this topic extensively and explains the uniquely American societal forces that are contributing to us being generally more miserable. It’s a lot of things beyond an individuals’ control: unstable job market, expensive health insurance tied to those unstable jobs, out of control housing and childcare costs, as well as current middle-agers being part of a sandwich generation. They often have to manage and fund expensive and complex eldercare for their parents while also helping their children make their way in a challenging world. Frank offers thoughts on what we can and cannot do about all this.
We also talk with musician Mike Doughty. Last time he was on, he was fresh out of in-patient psychiatric care and hitting the road with his once highly estranged band Soul Coughing. We find out how he’s doing now, how he made amends with his audience, and why an unplugged satellite dish matters so much.
Thank you to all our listeners who support the show as monthly members of Maximum Fun.
Check out our I’m Glad You’re Here and Depresh Mode merchandise at the brand new merch website MaxFunStore.com!
Hey, remember, you’re part of Depresh Mode and we want to hear what you want to hear about. What guests and issues would you like to have covered in a future episode? Write us at depreshmode@maximumfun.org.
Depresh Mode is on BlueSky, Instagram, Substack, and you can join our Preshies Facebook group.
Help is available right away.
The National Suicide Prevention Lifeline: 988 or 1-800-273-8255, 1-800-273-TALK
Crisis Text Line: Text HOME to 741741.
International suicide hotline numbers available here: https://www.opencounseling.com/suicide-hotlines
Help support this show and unlock bonus content! Become a member at https://maximumfun.org/joindepreshCodependency and Covid on a Tiny Boat in the Middle of the Ocean, with Angela Harger-Thompson
27/07/2026 | 59 mins.Angela Harger-Thompson had moved to Hollywood to make it big in showbiz but soon fell victim to a devastating assault. There to comfort her was her intermittent boyfriend. She really liked him and thought his offer of a four-week, 4000 mile sailing voyage on the Pacific Ocean, accompanies by a small crew of strangers and a dog seemed like a good idea. The claustrophobic pressure of that situation, combined with the dangers of ocean travel, was compounded by the rapid emergence of the covid pandemic. That meant closed borders, dwindling provisions, and a fear of what would come next. Angela tells us of the codependency in play in this situation, how they finally reached semi-friendly shores, how the romance crumbled hard, and the fallout that ensued. It’s all detailed in her new book, Worst Tits Ever, a title that sprang from an angry missive from what had become her very much EX-boyfriend.
Thank you to all our listeners who support the show as monthly members of Maximum Fun.
Check out our I’m Glad You’re Here and Depresh Mode merchandise at the brand new merch website MaxFunStore.com!
Hey, remember, you’re part of Depresh Mode and we want to hear what you want to hear about. What guests and issues would you like to have covered in a future episode? Write us at depreshmode@maximumfun.org.
Depresh Mode is on BlueSky, Instagram, Substack, and you can join our Preshies Facebook group.
Help is available right away.
The National Suicide Prevention Lifeline: 988 or 1-800-273-8255, 1-800-273-TALK
Crisis Text Line: Text HOME to 741741.
International suicide hotline numbers available here: https://www.opencounseling.com/suicide-hotlines
Help support this show and unlock bonus content! Become a member at https://maximumfun.org/joindepreshMaybe It IS Time to Panic Over AI Chatbots and Mental Health with Maggie Harrison Dupré
20/07/2026 | 55 mins.This week, we take a look at a couple of acronyms that are soaring in popularity and ask what their widespread adoption means for mental health. Maggie Harrison Dupré of Futurism has been following the AI space closely and has an update on lawsuits related to chatbots’ culpability in numerous cases of attempted and completed suicides. She also explains some recent research about why prolonged engagement with the sycophantic computer programs can lead to spiraling out of reality. Then we’re joined by Dr. Thomas Rutledge for a look at drugs like Ozempic and Zepbound. While the drugs are so new that research is slim, some psychological issues can emerge, especially related to self image and identity. He asks if food cravings and thinking about food have occupied a lot of space in your mind for years, what happens when that goes away? It’s a complicated world we live in, Depresh Mode is here to help you make more sense of it.
Articles by Maggie Harrison Dupré:
Lawsuit: Bipolar Man Attempted Suicide After ChatGPT Poured Gasoline on His Religious Delusions
New Paper Proposes What Really Causes AI Psychosis
These Logs of ChatGPT Allegedly Driving a Suicidal Woman to Her Death Are Deeply Disturbing
Article by Thomas Rutledge:
Your Brain on GLP-1s: What We're Learning About the Mental Side
Thank you to all our listeners who support the show as monthly members of Maximum Fun.
Check out our I’m Glad You’re Here and Depresh Mode merchandise at the brand new merch website MaxFunStore.com!
Hey, remember, you’re part of Depresh Mode and we want to hear what you want to hear about. What guests and issues would you like to have covered in a future episode? Write us at depreshmode@maximumfun.org.
Depresh Mode is on BlueSky, Instagram, Substack, and you can join our Preshies Facebook group.
Help is available right away.
The National Suicide Prevention Lifeline: 988 or 1-800-273-8255, 1-800-273-TALK
Crisis Text Line: Text HOME to 741741.
International suicide hotline numbers available here: https://www.opencounseling.com/suicide-hotlines
Help support this show and unlock bonus content! Become a member at https://maximumfun.org/joindepresh
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About Depresh Mode with John Moe
Join host John Moe (The Hilarious World of Depression) for honest, relatable, and, yes, sometimes funny conversations about mental health. Hear from comedians, musicians, authors, actors, and other top names in entertainment and the arts about living with depression, anxiety, and many other common disorders. Find out what they’ve done to address it, what worked, and what didn’t. Depresh Mode also features useful insights on mental health issues with experts in the field. It’s honest talk from people who have been there and know their stuff. No shame, no stigma, and more laughs than you might expect.
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