For Whom the Cell Tolls: Cancer Biology

Welcome to our most CONTROVERSIAL episode yet! We address “Turbo cancer” (idk what’s specifically meant by this still but I outline the likely/historical geneses behind these cases), inflammation issues, central dogma basics, mRNA vaccine tech, the rise of the microbiome and its importance for health, and the likely (yet boring) underlying sources of the rising cancer diagnoses among Millennials and younger Gen X patients. We’ll cover what stages and “bombs” were set decades ago. I wish that I had more time to keep going, so maybe we’ll do a part 2 since this is a big, complicated story worth telling, even if the statistically likely ending is sadder and less exciting than most accounts. We’ll break down the shifts in Biology, social media’s ability to spread stories and fear, and the best steps to remain healthy (mostly common sense). I totally forgot to mention microplastics (and nanoplastics) by name in the end of the episode. Consider them some of the most villainous contaminants! Sung 2024: https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(24)00156-7/fulltextMy other links: https://profkeenanhartert.weebly.com/Check out my new show where I interview my MSU students about their stories and successes in “Degrees Between Us”! It’s a video show, so the YouTube link might be easiest: https://youtube.com/playlist?list=PLnwMyklYPGa-Q7rn4W73K_f5jk_szGFRf&si=h_9PWi1jwHGm4mo2

Welcome to a special episode where I'm joined by 11 of my Minnesota State students as we close out our Cancer Biology lecture! We weave through discussions surrounding generational causes of cancer, potential next-generation hallmarks, treatment & financial ethics, and what the future hold for this disease as a whole. All said, this one is super fun because there are contributions from pre-med, pre-dental, and pre-STEM students in the room. These 11 wanted to be here, and their enthusiasm shows. I'm grateful for this group and the opportunity to teach.

The basic answer is no. When faced with R-CHOP resistance, DLBCL patients now have the option to utilize genetically modified Chimeric Antigen Receptor T-cells (CAR-T) designed to hunt tumors. This episode investigates the recent controversy into if these super-cells can transition into a villainous tumor themselves. We cover a paper by Garcia et. al. that showcases how much power we are adding to CAR-T, even activating oncogenes to do it. Next, we transition to a large analysis from Stanford where 724 patients are examined, with 1 developing a T-cell tumor. Sequencing this case reveals that no synthetic vector DNA integrations or activity is within the tumor. It ends up revealing a great surprise about shared evolutionary pathways between B & T-cell progenitor stem cells. Enjoy the episode! Follow me on YouTube or Instagram for more fun cancer/teaching content :) Hamilton Paper (TCL After CAR-T): https://www.nejm.org/doi/full/10.1056/NEJMoa2401361 Garcia Paper (CARD11 in CAR-T): https://www.nature.com/articles/s41586-024-07018-7

Hello! I’m recently returned from my annual ASH meeting where I see all of the latest advances in blood cancers. This specific facet was my favorite: small, insurgent populations of healthy B-cells portend better survival because they prime your T-cells to keep fighting. Super cool! I also have some mother grey stories from the meeting to share that I’m hopeful to get out on another episode. Thank you as always for listening!

Welcome back! It's been a while. I'm excited to get going again with an episode on the emerging science of "ecotyping" the cells around tumors - the microenvironment. Ecology and Evolution of lymphoma tumors is only half the story. We needed to know more about the state of cells around the tumor. How do they affect the surrounding immune cells? Do they support the tumor? We examine the worst possible scenario: when very little remains except for tumor and support cells. What are the consequences for immune-specific therapies like CAR-T cells? Hopefully this episode provides a good intro to our new tools to measure the TME and how it can further advance precision cancer medicine. I hope that you enjoy! Steen: https://pubmed.ncbi.nlm.nih.gov/34597589/ Katlov: https://pubmed.ncbi.nlm.nih.gov/33541860/