Petri Dish

• Ep. 185 How to Make a Drug Pt 2: Libraries and Design

  On this second episode about drug discovery, we discuss small molecule drug libraries and the challenges behind rational design! Don't know what that means? Tune in to find out! References: https://www.frontiersin.org/articles/10.3389/fcell.2019.00107/full https://next.cancer.gov/discoveryresources/resources_ndl.htm https://www.molbiolcell.org/doi/10.1091/mbc.E22-08-0377 https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapy-treatment-certain-patients-duchenne-muscular-dystrophy https://www.goodrx.com/health-topic/gene-therapy/crispr-therapeutics-vertex-exa-cel https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/crispr-timeline

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• Ep. 184 How to Make a Drug Pt 1: A Target

  Hey everyone! Today's episode is about getting into the nitty gritty of drug discovery. We often benefit from the research and development that goes into the creation of drugs we use to treat illnesses without really understanding what goes into that process. In this first part, we will discuss how you conceptually begin the process. References: https://www.nature.com/articles/nrd2399 https://www.fda.gov/vaccines-blood-biologics/zolgensma https://cancerci.biomedcentral.com/articles/10.1186/s12935-019-0806-1 https://www.ncbi.nlm.nih.gov/books/NBK519062/ https://www.sciencedirect.com/science/article/pii/B9780128191828000338 https://www.sciencedirect.com/science/article/pii/0006291X89926788?via%3Dihub https://www.nature.com/articles/362841a0 https://www.sciencedirect.com/science/article/pii/S0305737220300554

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• Ep. 183 Influenza Pt 4: Vaccines and Pandemics

  Sorry for the COVID-related break in episodes everyone! In our return, we complete our series on influenza by discussing past epidemics and pandemics to understand how influenza has repeatedly led to large scale medical events. Then we will finish by discussing the current and future state of influenza vaccines! References: https://www.nejm.org/doi/full/10.1056/nejmp058281 https://www.nature.com/articles/nature08157 https://pubmed.ncbi.nlm.nih.gov/16208372/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578040/ https://www.who.int/news-room/spotlight/history-of-vaccination/history-of-influenza-vaccination https://www.scripps.edu/news-and-events/press-room/2020/20200623-wilson-universalflu.html https://www.cdc.gov/flu/season/faq-flu-season-2022-2023.htm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159335/ https://www.nature.com/articles/nrmicro.2017.118 https://www.sciencedirect.com/science/article/abs/pii/0042682278901538 https://www.cdc.gov/flu/prevent/flushot.htm https://www.science.org/content/article/innovative-universal-flu-vaccine-shows-promises-it-first-clinical-test https://www.science.org/doi/10.1126/science.aaz5143 https://www.nih.gov/news-events/nih-research-matters/using-mrna-technology-universal-flu-vaccine

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• Ep. 182 Influenza Pt 3: Whaddya Gonna Do About It?

  You've had the flu. You've had a cold. Maybe you've even had allergies! But how can you tell them apart? And if you even figure out that you do have influenza, are there any treatments you can take that can help? References: https://www.health.harvard.edu/staying-healthy/gastroenteritis-in-adults-a-to-z https://academic.oup.com/aje/article/182/4/294/113092 https://onlinelibrary.wiley.com/doi/full/10.1111/irv.12515 https://www.cdc.gov/flu/about/burden/preliminary-in-season-estimates.htm https://newsinhealth.nih.gov/2014/10/cold-flu-or-allergy https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0000221 https://www.cdc.gov/mmwr/volumes/71/wr/mm7150a4.htm https://www.mobihealthnews.com/news/lucira-health-files-bankruptcy-it-receives-eua-home-covid-19-flu-test https://www.fda.gov/news-events/press-announcements/fda-authorizes-first-over-counter-home-test-detect-both-influenza-and-covid-19-viruses https://www.nature.com/articles/s41598-019-39683-4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108042/ https://www.cdc.gov/flu/treatment/antiviralresistance.htm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404498/ https://www.mdpi.com/2076-2607/11/1/183 https://www.jbc.org/article/S0021-9258(21)00260-X/fulltext

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• Ep. 181 Influenza Pt 2: The Piggies

  Last episode we discussed the current H5N1 flu that is hitting birds pretty hard. But is bird flu different from swine flu? Is there just a 'human flu', or do we only catch influenza from other animals? Let's get into the evolutionary history of the flu and primary hosts! References: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328453/ https://www.ncbi.nlm.nih.gov/books/NBK8611/ https://journals.asm.org/doi/full/10.1128/JVI.01080-14 https://www.cdc.gov/flu/weekly/index.htm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268205/ https://www.woah.org/en/disease/avian-influenza/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784916/ https://www.frontiersin.org/articles/10.3389/fevo.2018.00131/full https://www.science.org/doi/10.1126/science.1176225 https://pubmed.ncbi.nlm.nih.gov/32967956/

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