DiabetesBio

• A special extended “Sweet Talk” episode on the debate between GIP receptor agonism and GIP receptor antagonism, with Daniel Drucker, OC, MD, FRCPC, FRSC, FRS, and Jonathan Campbell, PhD.

  Welcome to the August 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2025 issue of Diabetes. 6:55 For this month’s episode, a special extended edition of “Sweet Talk,” exploring the debate about whether GIP receptor agonism or GIP receptor antagonism holds the most promise for therapeutic strategies. First, our hosts are joined by Daniel J. Drucker, OC, MD, FRCPC, FRSC, FRS, recipient of the American Diabetes Association’s (ADA) 2014 Banting Medal for Scienfitic Achievement for his research with GLP-1s. They also speak with Jonathan Campbell, PhD, Associate Professor in Medicine at the Duke Molecular Physiology Institute at Duke University. They discuss the history of endocrine biology research and their article, “Therapeutic Targeting of the GIP Receptor—Revisiting the Controversies,” available for free at doi.org/10.2337/db25-0393. 42:00 As the conversation continues, our guests discuss the controversy of the GIP receptor agonism, antagonism debate. These arguments are highlighted in a special debate series in the August issue of Diabetes, featuring a point article, “A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity,” available for free at ​​doi.org/10.2337/dbi24-0026, and a counterpoint article titled “GIP Receptor Antagonists in the Pharmacotherapy of Obesity: Physiologic, Genetic, and Clinical Rationale,” also available for free at doi.org/10.2337/dbi24-0027. And don’t forget to reach out! Let us know your stance in the debate between agonism and antagonism, and share your favorite science-related podcasts! To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

  --------  

  59:51

  --------

  59:51
• Suganami & Tanaka on regulation of adipose tissue fibrosis, Watanabe on genetic variations in GCKR & PNPLA3 regulating metabolic balance across the liver, “Sweet Talk” with the 2025 Albert Renold Distinguished Career Award recipient Barbara B. Khan

  Welcome to the July 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2025 issue of Diabetes. 6:50 In the first interview segment, our hosts discuss July’s Paper of the Month, titled “Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis.” They’re joined by corresponding authors Dr. Takayoshi Suganami, professor in the Department of Molecular Medicine and Metabolism, the Research Institute of Environmental Medicine at Nagoya University in Nagoya, Japan, and Miyako Tanaka, a lecturer in the same department. This article is available for free at doi.org/10.2337/db24-0762. 22:25 Our hosts speak with Richard M. Watanabe, PhD, Professor of Population and Public Health Sciences in the Department of Population and Public Health Sciences at the University of Southern California Keck School of Medicine. His paper, “Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver,” is available at doi.org/10.2337/db24-0923. 46:50 In this month’s edition of “Sweet Talk,” our hosts are joined by Barbara B. Kahn, MD, recipient of the American Diabetes Association’s Albert Renold Distinguished Career Award, to discuss her work uncovering key molecular mechanisms contributing to type two diabetes and the role of adipose tissue in regulating systemic insulin sensitivity. Dr. Kahn is the George Richards Minot Professor of Medicine at Harvard Medical School and Vice Chair for Research Strategy at Beth Israel Deaconess Medical Center in Boston. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

  --------  

  1:18:40

  --------

  1:18:40
• Okamoto & Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Kowalski on the effect of small blood glucose increases on endogenous glucose production, Sweet Talk with the 2025 Outstanding Scientific Achievement Award recipient Kajimura

  Haruka Okamoto & Kehan Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Greg Kowalski on the effect of small blood glucose increases on endogenous glucose production, and “Sweet Talk” with the 2025 Outstanding Scientific Achievement Award recipient Shingo Kajimura. Welcome to the June 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2025 issue of Diabetes. 4:40 In the first interview segment, our hosts discuss June’s Paper of the Month, titled “Hepatic PKA Mediates Liver and Pancreatic α-Cell Cross Talk.” They’re joined by corresponding author Dr. Haruka Okamoto, Director of Obesity Research at Regeneron Pharmaceuticals, and lead author Dr. Kehan Bao, a postdoctoral fellow at Regeneron. This article is available for free at doi.org/10.2337/db24-0958. 17:25 Our hosts speak with Greg M. Kowalski, PhD, Associate Professor with both the School of Medicine and the Institute for Physical Activity and Nutrition at the Deakin University’s Faculty of Health in Victoria, Australia. He is the corresponding author of a featured article in the June issue, “The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans,” available for free at doi.org/10.2337/db24-0388. 33:55 In this month’s edition of “Sweet Talk,” our hosts are joined by Shingo Kajimura, PhD, professor at Beth Israel Deaconess Medical Center in Boston and the recipient of the ADA’s 2025 Outstanding Scientific Achievement Award. They discuss his work with brown and beige fat control and their effects on energy balance and metabolic health. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

  --------  

  55:11

  --------

  55:11
• Michael Rickels on predicting metabolic outcomes through beta cell secretory capacity, Mark Atkinson on the ADA’s upcoming Scientific Sessions, and 2025 Banting Medal recipient Steven Kahn

  Welcome to the May 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2025 issue of Diabetes.  6:25 In the first interview segment, our hosts discuss May’s Paper of the Month, titled “β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation.” They’re joined by corresponding author Michael R. Rickels, MD, MS, Willard Rhoda Ware Professor in Diabetes and Metabolic Diseases in the Division of Endocrinology, Diabetes, and Metabolism Department of Medicine at the University of Pennsylvania Perelman School of Medicine, and and co-host of the podcast Diabetes Care On Air. This article is available for free at doi.org/10.2337/db24-0729  25:30 It’s a special two-part edition of “Sweet Talk.” In part one, our hosts focus on the upcoming 85th Scientific Sessions of the American Diabetes Association. They’re joined by Mark A. Atkinson, American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at The University of Florida, and chair of this year’s Scientific Sessions programming committee.  48:10 In part two, our hosts speak with Steven Kahn, MB, ChB, Professor of Medicine at the University of Washington (UW) and Director of the UW Diabetes Research Center. Dr. Kahn is the 2025 recipient of the American Diabetes Association’s Banting Medal for Scientific Achievement, and he discusses his landmark paper, “Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function,” available for free at doi.org/10.2337/diab.42.11.1663.  They also discuss the legacy of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in honor of its 75th anniversary. A special compendium of NIDDK studies is available at diabetesjournals.org/collection/2745/NIDDK-75th-Anniversary-Collection.  To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

  --------  

  1:15:54

  --------

  1:15:54
• Jennifer Bruin & Lahari Basu on cisplatin exposure and the dysregulation of insulin, Amit Majithia on AF-1 domain inhibition as an insulin sensitization target, and a Sweet Talk special remembrance with Maren Laughlin, Julio Ayala, and Shawn Burgess

  Welcome to the April 2025 episode of DiabetesBio—the American Diabetes Association’s podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2025 issue of Diabetes.  6:30 In the first interview segment, our hosts discuss an article titled “Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice.” They’re joined by corresponding author Jennifer E. Bruin, BSc, PhD, an associate professor in the Department of Biology and Institute of Biochemistry at Carleton University in Ottawa, Canada, and lead author Lahari Basu, PhD candidate at Carleton University. This article is available for free at doi.org/10.2337/db24-0419.  25:20 Our hosts discuss the latest Paper of the Month, entitled “An Alternatively Translated Isoform of PPARG Suggests AF-1 Domain Inhibition as an Insulin Sensitization Target.” They’re joined by corresponding author Amit R. Majithia, MD, Associate Professor in the Division of Endocrinology in the Department of Medicine at the UC San Diego School of Medicine. This article is available for free at doi.org/10.2337/db24-0497.  38:55 In the special edition of “Sweet Talk,” our hosts reflect on the life and legacy of David Wasserman, PhD, a pioneer in metabolic research with a lasting impact in exercise physiology, glucose metabolism, and diabetes. They’re joined by the people who knew him best: Maren Laughlin, PhD, Senior Advisor for Integrative Physiology at the National Institutes of Health, Julio Ayala, PhD, Director of the Vanderbilt Mouse Metabolic Phenotyping Center, and Shawn Burgess, PhD,  professor at UT Southwestern Medical Center in Dallas, Texas.  To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don’t forget to smash that “follow” button!

  --------  

  1:12:02

  --------

  1:12:02

More Science podcasts

Trending Science podcasts

About DiabetesBio

DiabetesBio: Podcasts in Family