This Week in Cardiology

ESC recaps on the SINGLE-AF trial, CMR Guide trial, two ATTR studies, PVI-SHAM-AF, STAREE, and an observational study of ICD benefit over the past decades are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I SINGLE-AF Trial
To Anticoagulate or Not in Intermediate-Risk AF: The SINGLE-AF Trial https://www.medscape.com/viewarticle/anticoagulate-or-not-intermediate-risk-af-single-af-trial-2026a1000uko
SINGLE-AF https://www.nejm.org/doi/10.1056/NEJMoa2607978
II Scar as an ICD risk stratifier
Is Scar on CMR an Indication for ICD? CMR Guide Leaves Doubts
https://www.medscape.com/viewarticle/scar-cmr-indication-icd-cmr-guide-leaves-doubts-2026a1000ukq
CMTR GUIDE Trial https://jamanetwork.com/journals/jama/fullarticle/2853395
MADIT II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa013474
III Single vs Dual Therapy in ATTR-CM
HELIOS-B Trial Sub-analysis https://www.sciencedirect.com/science/article/pii/S0735109726072086
HELIOS-B Sub-analysis Editorial https://www.sciencedirect.com/science/article/pii/S0735109726073766#bib8
HELIOS-B main trial https://www.nejm.org/doi/10.1056/NEJMoa2409134
CARDIO-TTRansform Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608510
IV A Stunning Result of another Sham-controlled AF ablation trial
Does AF Ablation Work? That's in Question After PVI-SHAM-AF https://www.medscape.com/viewarticle/does-af-ablation-work-s-question-after-sham-pvi-af-2026a1000uli
PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link
SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283
PFA-Sham Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484
V Should Older Adults Take Statins: The STAREE trial.
STAREE Strengthens Case for Over-the-Counter Statins https://www.medscape.com/viewarticle/staree-strengthens-case-over-counter-statins-2026a1000vrw
STAREE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607314
VII Declining ICD Benefit After MI  
Mortality Reduction with ICD for Prevention of SCD Post-MI  https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag706/8768943 
CONTEMP-ICD Trial https://clinicaltrials.gov/study/NCT06543446 
PROFID-EHRA Trial https://profid-project.eu/profid-ehra-trial/ 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback on Mechanical Compression Devices for OHCA
 
Mechanical CPR Device Use and Cardiac Arrest Survival
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272
PARAMEDIC trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext
CIRC trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext
LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037
Cochrane Review – Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/
II PFA and Stroke
Risk of Stroke and TIA With PFA vs RF Ablation https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.081092
AVANT GUARD Trial https://www.nejm.org/do/10.1056/NEJMdo008538/full/
EMBOL-AF Registry https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag217/8566008
III A New ICD Lead
LEADR LBBAP Trial https://doi.org/10.1016/j.hrthm.2026.08.030
IV ESC Preview
Mandrola's Preview of the European Society of Cardiology 2026 https://www.medscape.com/viewarticle/mandrolas-preview-european-society-cardiology-2026-2026a1000tfi
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

Mechanical CPR devices, the dangers of AF performance measures, two scholarly articles on CLOSURE and CHAMPION, and a little ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. 
This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Mechanical Compression Devices for OHCA
·       Mechanical CPR Device Use Cardiac Arrest Survival
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272
·       PARAMEDIC Trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext
·       CIRC Trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext
·       LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037
·       Cochrane Review of Mechanical vs Manual Chest Compressions for Cardiac Arrest  https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/
II ACC AF Performance Measures
·       2026 AHA/ACC Clinical Performance for Patients With AF https://www.jacc.org/doi/10.1016/j.jacc.2026.05.032#sec-3
III Two Critical Appraisals of the recent LAAC trials
·       Reappraising CHAMPION-AF 10.1016/j.hrthm.2026.07.048 External Link
·       CHAMPION and CLOSURE: Reconciling Contrast Results https://doi.org/10.1093/eurheartj/ehag608
ESC Early Preview
·       CMR Guide trial https://pmc.ncbi.nlm.nih.gov/articles/PMC6931571/
·       SINGLE AF Trial 10.1016/j.hroo.2025.12.008 External Link
 You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

Listener feedback, the ZEUS trial fails, a fascinating statin trial, more on GLP-1 drugs, and radiation safety in the EP lab are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I ZEUS Fails
Rethinking Inflammation and ASCVD: Four Lessons From the ZEUS Trial
https://www.medscape.com/viewarticle/rethinking-inflammation-and-ascvd-four-lessons-zeus-trial-2026a1000rlm
ZEUS Trial https://doi.org/10.1001/jamacardio.2025.4491
II Statins and the Elderly
SAGA/SITE trial 10.1016/j.lanhl.2026.100884 External Link
III GLP-1 and CV Risk
SURMOUNT-1 Trial https://www.nejm.org/doi/10.1056/NEJMoa2206038
SURMOUNT-1 Post Hoc Analysis https://www.jacc.org/doi/10.1016/j.jacc.2026.04.044
Reframing GLP-1s as Cardiometabolic Health Drugs: Editorial https://www.jacc.org/doi/10.1016/j.jacc.2026.06.039
IV Radiation Exposure to the Uterus in the EP Lab
Occupational Radiation Safety in EP During Pregnancy https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.080556
Survey: Working in Cath Lab During Pregnancy https://www.surveymonkey.com/share/d5c1edf7-6d99-49d4-a9fa-e9168f63ab55
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588
II Another Failure of Posterior Wall Isolation
CORNERSTONE-AF Trial https://doi.org/10.1093/eurheartj/ehag486
CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186
PVIOTAL IDE Trial 10.1016/j.hrthm.2025.08.018 External Link
III First Line AF ablation – One new study and a discovery about a second one
Catheter Ablation vs AAD for First-line Treatment of AF 10.1016/j.hrthm.2025.07.061 External Link
EAST-AFNET 4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2019422
Cardiology Trials Substack https://cardiologytrials.substack.com/p/summary-and-discussion-of-east-afnet
IV Left Atrial Appendage Closure Meta-analysis
Long-Term Efficacy and Safety of LAAC vs OAC -- Meta-analysis https://academic.oup.com/europace/article/28/7/euag159/8739567
V Prevention of AKI after Cardiac Surgery: MERCURI-2
MERCURI-2 Study https://jamanetwork.com/journals/jama/fullarticle/2852324
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net