NB Hot Topics Podcast

Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this episode, we have three new pieces of research and a special interview later on discussing the recommendations of the National Screening Committee on prostate cancer screening in the UK.
First up for research: nasal sprays versus the common cold. The BJGP reports on longer-term findings through this simple intervention. Can it help this age-old problem?
Second, new kid on the block, orforglipron - could it replace SGLT2 inhibitors for management of type 2 diabetes?
Third, home-based hypnotherapy. Can it help children struggling with functional abdominal pain or IBS? We have a RCT to tell us. 
Finally, our interview with Dr Liz Bancroft, consultant nurse in oncogentics research, and Natalia Norori, interim Head of Data and Evidence at Prostate Cancer UK join us to discuss the new recommendations from the National Screening Programme with targeted screening of men with BRCA2, why they made this recommendation and how this affects us in general practice, plus what we need to know for our patients about the government-backed trial, TRANSFORM.
References
Prostate Cancer UK Information on NSC decision
Prostate Cancer UK Health Professional NSC FAQs
National Screening Committee report on prostate cancer screening
BJGP Nasal sprays for the common cold
Lancet Nasal Sprays original paper
Lancet Orforglipron vs dapagliflozin and T2DM
BJGP Hypnotherapy in children for abdo pain
National Screening Committee report on prostate cancer screening
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Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. Lots going on in this new episode! 
Three new pieces of research and an interview with Dr Anna Martinez, consultant paediatric dermatologist at GOSH, talking about a skin fragility condition many of us may not have heard of before - epidermolysis bullosa - in conjunction with DEBRA, the leading charity for EB awareness and research. 
In research, we look at two papers published this week in finerenone. Does it have a role in CKD management in patients without diabetes, and if so, how good is it?
Second, retatruide - the latest injectable weight loss medication making a splash across the headlines - could it be used as monotherapy for recent onset type 2 diabetes?
Resources
NB Medical Epidermolysis bullosa free online educational module
DEBRA
NEJM Finerenone for CKD
Lancet Finerenone MA
Lancet Retatrutide for early T2DM
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Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. More new research to discuss for the world of general practice.
First, which antibiotic is actually best for managing uncomplicated UTI - is UK guidance offering the best choice to women?
Second, are you using the Kidney Failure Risk Equation in your patients with CKD? New research on how your risk of death may be much more important than your risk of end-stage renal disease.
Finally, does empathy work in telephone consultations, and can it improve important hard outcomes such as symptom control?
References
Lancet Abx for UTI
BJGP Kidney Failure Risk Equation, Death and ESRD
Kidneyfailurerisk.co.uk
BJGP Empathy and the telephone
CARE measure
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Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. In this episode, we have three new pieces of research that affect us in general practice. 
First: What interim anti-coagulation would you give your patient with suspected VTE? One common option has 5 times the rate of major bleeding.
Second: How much muscle mass do people lose with weight loss on GLP1s? Is this different from lifestyle-based interventions, and is there anything patients can do about it?
Third: Why don't we use clinical decision support tools for cancer? This research looks at the barriers and then I over-share my own thoughts on the subject...

References
NEJM Apixaban or rivaroxaban bleeding risk with acute VTE
Diabetes, Obesity & Metabolism Lean mass loss with incretin therapies vs lifestyle interventions
BJGP: Why don't we use clinical decision tools
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Welcome to the Hot Topics podcast from NB Medical with Dr Neal Tucker. Three new research papers to help us along our way in general practice this month.
First, how long do modern hip replacements last? How does this new data change our conversation with patients?
Second, it's thought GLP1 agonists could have a role in addiction management, but so far, research has failed to show a definitive benefit. Could new data from the US on veterans with type 2 diabetes show a different picture? 
Finally, what analgesia would you recommend for a child in pain? This new paper compared ibuprofen with or without paracetamol or hydromorphone - yes, an extremely potent long-acting opioid for kids. Good idea? We find out.

References
Lancet Hip replacement longevity
Lancet THR Editorial
BMJ GLP1ra and addiction
BJP editorial
JAMA Analgesia and Child  
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