The GP Show

Twenty-five years ago, having a baby daughter struggling with severe hives turned GP Dr. Alison Muller into an accidental allergy guru - and general practice has been better for it since. She unpacks IgE vs non-IgE reactions, why 10% of one-year-olds now have a genuine food allergy, why smearing avocado oil on eczema is asking for trouble, and why anaphylaxis rates are up 900% in twenty years. Plus she gives us the practical tips we need such as weight-based antihistamine dosing, the three-ingredient "magic cream" for infected eczema, and why putting your clothes in the dryer for ten minutes might be the cheapest allergy hack around.
If you have ever ordered a RAST and had a result telling you that someone is "allergic to grass" and not really known what to do next, or you've wondered whether desensitisation is worth the needles (and what exactly is involved?!), then this podcast is for you. Alison covers exercise-induced food anaphylaxis, FPIES, and even Neffy - the new nasal adrenaline spray that might finally get more people to use their emergency treatment when it counts. A great one not to miss!
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Study and learn lifestyle medicine:  Interested in whole of person clinical practice, research and careers that address the lifestyle and social determinants of illness and wellbeing, using lifestyle approaches, behaviour change, health coaching and implementation science?  Check out the JCU College of Medicine postgraduate degrees: Graduate Certificate, Graduate Diploma, and Master in lifestyle medicine.
Dr Sam Manger on YouTube: Using lifestyle as medicine: A new era in chronic disease remission and YouTube: Careers in lifestyle medicine
The 3 week online microcredential in Lifestyle Medicine and Mental Health: Life and Mind available here.

Dr Chris Davis is a GP, Co-Founder and CMO of the Clean Slate Clinic, Australia's leading virtual detox and recovery service, and an Addiction Specialist at St Vincent's Hospital, Sydney. He established the Clean Slate Clinic in Sydney for primary care alcohol withdrawal and recovery services, after successfully implementing the model in the UK. His teams inspiring work demonstrates highly effective, more accessible and supportive care in recovery and continues to scale nationally.
https://cleanslateclinic.com/
Cracking Addiction Podcast - https://podcasts.apple.com/au/podcast/cracking-addiction/id1579789505 
Episode #139 of The GP Show where we first met Dr Chris - https://thegpshow.libsyn.com/139-alcohol-recovery-and-the-clean-slate-clinic-with-dr-chris-davis-and-flip-prior
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If you find this podcast valuable, please help by rating the podcast 5 stars and leaving a review in your podcast app.
If you would like to request a topic, please contact us via contact@thegpshow.com 
Thank you for listening and your support.
... 
Study and learn lifestyle medicine:  Interested in whole of person clinical practice, research and careers that address the lifestyle and social determinants of illness and wellbeing, using lifestyle approaches, behaviour change, health coaching and implementation science?  Check out the JCU College of Medicine postgraduate degrees: Graduate Certificate, Graduate Diploma, and Master in lifestyle medicine.
Dr Sam Manger on YouTube: Using lifestyle as medicine: A new era in chronic disease remission and YouTube: Careers in lifestyle medicine
The 3 week online microcredential in Lifestyle Medicine and Mental Health: Life and Mind available here.

Professor Jayashri Kulkarni is one of Australia's leading psychiatrists and researchers specialising in women's mental health. She is the Director of the HER Centre Australia (Health, Education and Research for Women's Mental Health) and Professor of Psychiatry at Monash University. Professor Kulkarni's work focuses on mood disorders across the female lifespan, with particular attention to the neurochemical effects of reproductive hormones on brain function, including perimenopausal depression and premenstrual dysphoric disorder. She is the developer of the Meno-D rating scale and has been a leading voice for over four decades in the recognition and treatment of hormone-related mental illness in women.
This is a supplementary episode to the GP Show's earlier conversation with Professor Kulkarni on perimenopausal mental health, recorded in the same sitting. In it, Dr. Ashlea Broomfield and Professor Kulkarni discuss what distinguishes PMDD from common premenstrual symptoms; the emerging evidence on trauma and gene expression as a mechanism for PMDD onset; why current guidelines default to SSRIs rather than hormonal treatment and the limitations of that approach; practical hormonal treatment options for women with and without contraceptive needs; and the role of trauma therapy alongside hormonal management. Professor Kulkarni argues that PMDD is a brain condition, not an end-organ condition, and that treatment should reflect that.
RESOURCES
"How to Treat PMDD" — Professor Jayashri Kulkarni, Australian Doctor. Read here
UK Guidelines: The Green-top Guideline 48 — Management of Premenstrual Syndrome Green LJ, O'Brien PMS, Panay N, Craig M on behalf of the Royal College of Obstetricians andGynaecologists. Management of premenstrual syndrome. BJOG 2017 ; 124:e73–e105
HER Centre Australia — monash.edu/medicine/her-centre
Perimenopausal Mental Health episode — The GP Show with Professor Jayashri Kulkarni
Fast Facts in Sexual and Reproductive Health with Dr. Sara Whitburn — The GP Show 
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If you find this podcast valuable, please help by rating the podcast 5 stars and leaving a review in your podcast app.
If you would like to request a topic, please contact us via contact@thegpshow.com 
Thank you for listening and your support.
... 
Study and learn lifestyle medicine:  Interested in whole of person clinical practice, research and careers that address the lifestyle and social determinants of illness and wellbeing, using lifestyle approaches, behaviour change, health coaching and implementation science?  Check out the JCU College of Medicine postgraduate degrees: Graduate Certificate, Graduate Diploma, and Master in lifestyle medicine.
Dr Sam Manger on YouTube: Using lifestyle as medicine: A new era in chronic disease remission and YouTube: Careers in lifestyle medicine
The 3 week online microcredential in Lifestyle Medicine and Mental Health: Life and Mind available here.

Professor Jayashri Kulkarni is one of Australia's leading psychiatrists and researchers specialising in women's mental health. She is the Director of the HER Centre Australia (Health, Education and Research for Women's Mental Health) and Professor of Psychiatry at Monash University. Professor Kulkarni's work focuses on mood disorders across the female lifespan, with particular attention to the neurochemical effects of reproductive hormones on brain function, including perimenopausal depression and premenstrual dysphoric disorder. She is the developer of the Meno-D rating scale and has been a leading voice for over four decades in the recognition and treatment of hormone-related mental illness in women.
In this episode, Dr. Ashlea Broomfield speaks with Professor Jayashri Kulkarni about the mental health impact of perimenopause. They discuss the role of oestrogen and progesterone as neurosteroids influencing mood, cognition, and behaviour; why mood symptoms often precede vasomotor changes by years; which women are most at risk and why; the distinct clinical profile of perimenopausal depression and how to avoid common misdiagnoses; and how to approach hormonal treatment in practice (including contraceptive options, transdermal oestradiol, micronised progesterone, and tibolone) alongside a review of the evidence around MHT safety.
RESOURCES
"The primary care management of perimenopausal depression" — Kulkarni J et al. Australian Journal of General Practice 2026;55(4). Read here
HER Centre Australia — Research, clinical resources, and the Meno-D scale: monash.edu/medicine/her-centre
Meno-D rating scale — Available via HER Centre Australia and as an appendix in the AJGP article above
Healthy Hormones — GP-led community, resources, and webinars: healthyhormones.au
Australasian Menopause Society — Evidence-based guidelines and resources: menopause.org.au
Monash University women's mental health short course — Via HER Centre Australia (
PMDD companion episode — The GP Show with Professor Jayashri Kulkarni (link once live)
Fast Facts in Sexual and Reproductive Health with Dr. Sara Whitburn — The GP Show 
 
TIMESTAMPS
00:00 — Introduction, Welcome to Country, guest bio
03:40 — Reproductive hormones as brain neurosteroids: neurochemical effects of oestrogen and progesterone across the perimenopausal transition
12:19 — Risk factors for perimenopausal mood sensitivity: early life trauma, the HPA/HPG axis, and recognising hormonal sensitivity in clinical history
24:28 — Diagnostic considerations: the Meno-D scale, distinguishing perimenopausal depression from MDD and bipolar disorder, and current gaps in psychiatric classification
37:29 — MHT safety: reviewing the 2001 WHI study, absolute and relative contraindications, and monitoring in practice
45:33 — Treatment approaches: hormonal contraception, transdermal oestradiol, micronised progesterone, tibolone, and tailoring to the individual
59:16 — Further resources and preview of the PMDD companion episode
 
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If you find this podcast valuable, please help by rating the podcast 5 stars and leaving a review in your podcast app.
If you would like to request a topic, please contact us via contact@thegpshow.com 
Thank you for listening and your support.
... 
Study and learn lifestyle medicine:  Interested in whole of person clinical practice, research and careers that address the lifestyle and social determinants of illness and wellbeing, using lifestyle approaches, behaviour change, health coaching and implementation science?  Check out the JCU College of Medicine postgraduate degrees: Graduate Certificate, Graduate Diploma, and Master in lifestyle medicine.
Dr Sam Manger on YouTube: Using lifestyle as medicine: A new era in chronic disease remission and YouTube: Careers in lifestyle medicine
The 3 week online microcredential in Lifestyle Medicine and Mental Health: Life and Mind available here.

Dr David Fineberg is a General Practitioner and PhD candidate at the University of Melbourne whose research focuses on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Long COVID. He is the founding clinician of the ME Research Clinic (MERC), a translational research hub dedicated to advancing the diagnosis, evaluation, and treatment of complex post-viral syndromes through an evidence-based, patient-centred model.  His PhD is "Precision Medicine techniques In the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS + Long Covid (PRIME)".
Episodes resources: 
MECFS diagnostic criteria from ME Research UK
DePaul Questionnaire
FUNCAP (Functional Capacity) Questionnaire
Open Medicine Foundation Resources and Clinical Guidelines
Visible App - wearable tech for illness, not wellness, designed for MECFS, POTS, EDS and Long Covid
RACGP Energy Limiting Disorders SIG and CPD CHECK
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If you find this podcast valuable, please help by rating the podcast 5 stars and leaving a review in your podcast app.
If you would like to request a topic, please contact us via contact@thegpshow.com 
Thank you for listening and your support.
... 
Study and learn lifestyle medicine:  Interested in whole of person clinical practice, research and careers that address the lifestyle and social determinants of illness and wellbeing, using lifestyle approaches, behaviour change, health coaching and implementation science?  Check out the JCU College of Medicine postgraduate degrees: Graduate Certificate, Graduate Diploma, and Master in lifestyle medicine.
Dr Sam Manger on YouTube: Using lifestyle as medicine: A new era in chronic disease remission and YouTube: Careers in lifestyle medicine
The 3 week online microcredential in Lifestyle Medicine and Mental Health: Life and Mind available here.