Good Life Project

Every year you get your blood drawn, and someone circles a number that supposedly tells you your inflammation level. Turns out that number is barely more accurate than a coin flip. But, knowing how chronically inflamed you are is critical in preventing disease and slowing the age clock.

David Furman directs the Stanford 1000 Immunomes Project and runs the Bioinformatics and Data Science Core at the Buck Institute for Research on Aging, where he's spent over fifteen years studying how inflammation drives the diseases most of us start worrying about in our forties and fifties: heart disease, dementia, diabetes, cancer. He's the researcher behind the first published clock that can predict frailty seven years before it shows up, and along the way he's worked with NASA and SpaceX.

What you'll explore in this conversation:

Why the inflammation test your doctor already runs is barely more accurate than flipping a coin, and what David built to replace it
The everyday object sitting in a lot of living rooms right now that's silently raising one of the 7 key drivers of inflammatory aging
How chronic stress can disable the anti-inflammatory drugs meant to fight it
The one daily habit David says adds roughly fifteen years to your healthspan, and it isn't the kind of exercise you'd expect
What David actually eats, and avoids, to keep his own inflammation in check

If you've ever wondered what's actually happening beneath the surface as you age, this conversation gives you a real way to find out, and a real place to start.

You can find David at: Website | LinkedIn | Episode Transcript

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We spend a lot of time weighing the cost of risking too much. Jimmy Chin has spent most of his life on the harder question, which is what it costs to risk too little, quietly, for twenty or thirty years, until the years are gone.

Jimmy Chin is an Academy Award-winning director, a National Geographic photographer, and a New York Times bestselling author. He made Free Solo, Meru, The Rescue, and Nyad, he skied off the summit of Everest, and he lived out of the back of a Subaru from 21 to 28. Then he turned fifty, started looking at his life in chapters, and went looking for people who could tell him what success meant to them at the start and what it means to them now. Those conversations became his new book, Rules to Live By: How Extraordinary Lives Define What Really Matters.

Here's what we get into:
The question Jimmy says he has been asking since he was ten years old, and why the answer keeps moving while the question never does
What one of the world's great cellists realized in the middle of a technically flawless performance, and where it sent him afterward
Why the founder of a three-billion-dollar company looked at his own growth numbers and felt sick, and the one sentence of his Jimmy channels at every crossroads
The difference between a kid wanting a parent alive and a kid wanting a parent to feel alive, and what it takes to hold both at once
What a seven-year-old said to her father at thirteen thousand feet that he is still thinking about six years later

If you have hit the season where the boxes are checked and the question underneath them has gotten louder, this one is for you.

You can find Jimmy at: Website | Instagram | Episode Transcript

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Nicholas Epley studies how people misjudge each other, avoid conversations with strangers, and miss out on life-affirming relationships. It all started when he noticed something on a silent Chicago train that changed how he thinks about the strangers he avoids and the people he loves but never calls. The thing stopping him wasn't what he expected.

Epley is a professor of behavioral science at the University of Chicago Booth School of Business, where he's spent over fifteen years studying why smart, socially wired people routinely misread each other. His research on human connection has appeared in the New York Times and on NPR, and he teaches an MBA course called Designing a Good Life. His new book is A Little More Social.

What you'll explore in this conversation:
Why the experiment that convinced Nicholas to talk to a stranger on a silent train started with him assuming it would go badly
The specific belief researchers found sabotages more conversations than shyness, rudeness, or bad timing combined
What his team discovered when they photographed people's resting faces, and why it explains a train car full of strangers staying quiet
A kind word tends to land better than a polished one, according to decades of research on how we actually judge each other. Nicholas breaks down why
Acting more outgoing than you feel might not cost the energy you'd expect, even for people who've called themselves introverts their whole lives

If there's someone you've been meaning to reach out to, or a stranger you keep talking yourself out of talking to, this conversation makes the case for testing that instinct instead of trusting it.

You can find Nicholas at: Website | LinkedIn | Episode Transcript

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She measured everything about her illness. The measuring turned out to be part of what kept her sick.

Giorgia Lupi is an information designer and a partner at Pentagram in New York, and one of the few people alive who can take raw data and turn it into something you understand in your bones and feel in your body. In 2020, a mild COVID infection set off four years of long COVID, chronic fatigue syndrome, POTS, mast cell activation, and a level of disability that left her housebound, out of work, and eating eight foods for an entire year.
Giorgia did what she does. She tracked every symptom, every test, every prognosis, and limitation. Then she published 1,374 Days, a visual op-ed in the New York Times built from her own symptom data, and readers with chronic illness wrote to say it was the first thing they could hand to the people who loved them.

That, however, was just the beginning of a story of recovery that was about to take a wild, transformative turn. One that would find her rethinking her approach to measuring what was wrong and shifting to the opposite, realizing, all too often, that what we measure reinforces our reality.

In this conversation, you'll explore:
The number of practitioners she saw over four years before a single one offered to coordinate her care, and what her body did in that exact moment, before any new treatment was tried
What she took off her wrist and archived on her hard drive, after believing for years that it was the thing keeping her safe
The first entry in the new spreadsheet she opened in 2024, and why something that small was the turn
Why the online illness communities she went to for support sent her home more frightened every time, and what she went looking for instead
How she started charting a different kind of data, and finding new answers that not only refuted much of the dire prognosis she’d been given, but also, slowly, brought her back to life.
Why her working definition of recovery now, which is not the one she wrote down while she was sick, is not "getting back to normal"

A note on how we held this one. Giorgia is careful, and so are we. This is her story and not a protocol, her symptoms were real, documented in labs, and measurable, and nobody in this conversation is suggesting anyone thinks their way out of illness.

If you have ever looked fine from the outside while something underneath was quietly giving way, this is a conversation about what your body might be trying to tell you before it has to shout.

You can find Giorgia at: Website | Instagram | Episode Transcript

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Shawn Achor spent twelve years at Harvard studying the science of belief and success, and his TED talk has been watched more than 25 million times. His new book, The Power of Beliefs, grew out of research with the NFL, NASA, and six Marine battalions at Camp Pendleton, and out of watching his own daughter fight for her life three months early.

The 7 core beliefs that control much of our lives, without us knowing it
Why believing you’re alone in your effort can make hard things harder.
The two small words that turn a hollow pep talk into a path to success.
What a stranger's ten seconds on an escalator taught Shawn about the difference between mattering less and not mattering at all.
A five-minute weekly habit Shawn's family calls the Memory DeLorean, and what it does to the story you tell about a hard season.
How time-stress can make you abandon everything you believe is important.
How to harness hidden beliefs to feel more alive and connected, and thrive in all parts of life.

For anyone in a season where the ground feels tilted against them, this is a reminder that the tilt might be more changeable than it feels.

You can find Shawn at: Website | Instagram | LinkedIn | Episode Transcript

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