The Optispan Podcast with Matt Kaeberlein

• Why 400+ Alzheimer's Drugs Failed (Here's What Works)

  Alzheimer’s is often talked about but rarely understood in full. For decades, most research has focused on amyloid plaques, but what if that’s only part of the story? In this deep-dive, Dr. Cory, from the Institute for Systems Biology explains a new way of looking at Alzheimer’s: It is not simply a plaque problem, but as a breakdown in the brain’s “debris management” system, especially how it handles cholesterol. This perspective connects the dots between genes like ApoE4, the role of microglia, and everyday factors like sleep and stress. It also helps explain why current drugs give mixed results, and what might actually work in the future. Dr. Cory also shares practical insights on prevention and what a new era of treatment could look like .This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here: www.onebillionmedia.comIf you want to understand where the future of Alzheimer’s prevention and treatment is headed, watch this podcast now!

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• Female Biohacker: Why Women Need Different Longevity Protocols (Simple Steps)

  Ever wondered how simple, consistent practices can transform your health? In this episode, Kayla Barnes shares her personal journey from growing up on a standard diet to discovering the science-backed habits that help manage toxin exposure, support heart and brain health, and reduce stress.She talks about:• How her environment affected her toxin levels and what helped bring them down• The surprising benefits of sauna and why long-term practices matter• The early health choices that set her up for performance and longevityAnd much more!Timestamps:00:00:00 – Kayla’s Journey From Performance Geek to Longevity Clinician00:05:23 – Decoding Biomarkers & The Business of Longevity Medicine00:19:31 – Lifestyle is First: Sleep, Exercise & Real Food as Medicine00:31:41 – Beyond Basics: Detox, Saunas & Cutting-Edge Therapies00:37:18 – Deep Dive on Detox: Therapeutic Plasma Exchange (TPE)00:44:13 – Hyperbaric Oxygen & Red Light Therapy: Protocols and Benefits00:50:29 – A Critical Look at Biohacking: Over-Extension & Self-Experimentation00:53:17 – Women's Health & Longevity: Unique Challenges and Excitement00:53:17 – The Female Longevity Gap: Hormones, Ovaries & Research Blind Spots00:59:37 – Closing Thoughts & Key TakeawaysDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://x.com/mkaeberlein Linkedin:   / optispan  Instagram:   / optispan_   TikTok:   / optispan  https://www.optispan.life/

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• AI Medicine: ChatGPT Reads Blood Tests Faster Than Your Doctor

  Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Most people take supplements without ever checking if their body actually needs them. Is that smart… or just expensive guesswork?In this podcast, Dr. Matt Kaeberlein sits down with Ryan Ware to unpack the truth about supplements, the rise of AI in medicine, and how people are consuming health information today. From internet “gurus” to tools like ChatGPT, they explore where people are searching for health answers, and whether those answers are truly helping or quietly harming.Along the way, they share critical reflections on the wellness industry’s blind spots, the limitations of blood tests, and what smarter, evidence-based health decisions really look like.Join the conversation to find out what really matters for your health, and what’s just hype!This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:*www.onebillionmedia.com**Chapters*00:00 – ChatGPT vs. social media for health advice07:15 – Bloodwork, Dexa scans & functional testing14:30 – Proactive vs. reactive medicine21:45 – The doctor’s role in the AI era29:00 – Life-changing diagnostics: MRI, Dexa & CGM36:15 – Single biomarkers, noise & unreliable tests43:30 – Heavy metals, toxins & data challenges50:45 – HIPAA, biomedicine & broken data rules58:00 – AI bias, clinician oversight & misinformation01:05:15 – Pill mills, GLP-1s & hormone clinics01:12:30 – Scaling preventive care with AI01:19:45 – Why testing before symptoms mattersDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

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• Is Creatine Harming Your Kidneys? The Blood Test Myth Explained.

  Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Many people taking creatine get alarming results on standard kidney function tests, suggesting their kidneys are failing. This video explains why the popular supplement can create a false positive, debunks the myth of kidney damage, and reveals a more accurate blood marker you should know about.0:00 - The Creatine Dilemma1:00 - My Alarming Blood Test Results1:37 - Creatinine & EGFR: The Standard Test4:40 - The Better Marker: Cystatin C Explained6:32 - Proof: The Follow-Up Test7:35 - Who Else Is at Risk for a False Positive?8:42 - Conclusion: Should You Be Concerned?Production: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

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• Elite Performance: How Pro Athletes Use HRV to Train Smarter (Not Harder)

  In this episode, Dr. Matt Kaeberlein sits down with Joel Jamieson to explore the science of heart rate variability and how it connects to longevity, recovery, and performance. Joel shares his journey from training elite fighters to becoming a global authority on HRV training, emphasizing that healthspan is built on consistency, balance, and resilience rather than endless high-intensity workouts. The discussion dives into why VO2 max is one of the strongest predictors of longevity, how the parasympathetic nervous system and vagus nerve health regulate stress and recovery, and why zone 2 cardio, metabolic flexibility, and steady improvements in cardiovascular health matter more than chasing short-term results. This conversation reframes strength vs endurance, highlights key anti-aging biomarkers, and shows how recovery science can transform both athletes and everyday people seeking lasting health.

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