This Week in Parasitism

• TWiP 258: The deeper, the rounder

  TWiP describes how a gut commensal protozoan influences respiratory disease outcomes by shaping pulmonary immunity, and body shape variation in lice that parasitize diving hosts. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Gut commensal shapes pulmonary immunity (Cell) The deeper the rounder (Sci Rep) Become a patron of TWiP  Send your questions and comments to [email protected] Music by Ronald Jenkees

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• TWiP 257: Malaya and Malaysia

  TWiP solves the case of the man in the Malaysian city of Kucheng who presents with left arm swelling, and presents a new case for you to decipher. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 257 New Case We are still in Kuching, Malaysia in the northern part of the Island of Borneo. This is the Sarawak portion of Malaysia. A man in his late 30s is admitted to the hospital in December with daily fevers that last for several hours and shaking chills. He had previously been healthy with no medical problems. He lives in the city and works in an office, however, in the few weeks prior to getting admitted he was visiting the jungle. Apparently not too far outside of Kuching, one can go up into the jungle and see Orangutans. He had gone into the jungle but this was 2 weeks prior to the onset of symptoms. Since then he reports no unusual exposures. He lives with his wife and children and they are all healthy. A few days prior to admission he noted fever, chills, and a headache. He is a little nauseated but no vomiting. On exam he has a fast heart rate and appears ill. His respiratory rate is increased and he is not febrile on admission but later does have fever.  No enlargement of the liver or spleen on exam. Otherwise unremarkable. His labs are notable for low white blood cells, anemia, and a platelet count of less than 50k per microL. His coagulation studies are abnormal, serum creatinine is elevated, and there is elevation of his serum aminotransferases. Become a patron of TWiP  Send your questions and comments to [email protected] Music by Ronald Jenkees

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• TWiP 256: Amazing antimalarial drug resistance

  TWiP explains a study that carries out selection of Plasmodium falciparum in the presence of inhibitors to identify determinants of drug resistance, and a paleoparasitological analysis of a 5th–16th c. CE latrine. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Naegleria fowleri acquired at splash pad (MMWR) Determinants of P. falciparum drug resistance (Science) Paleoparasitological analysis of 5th–16th c. CE latrine (Parasitol) Become a patron of TWiP  Send your questions and comments to [email protected] Music by Ronald Jenkees

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• TWiP 255: Katayama fever

  Michelle Labrunda joins TWiP to solve the case of the Georgian in Guinea with fever and dry cough, and describe a new case for you to solve. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Guest: Michelle Labrunda Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Letters read on TWiP 255 New Case A man who is on eculizumab, a recombinant humanized monoclonal antibody that targets complement protein C5 which serves as a terminal complement inhibitor, comes in with left arm swelling. He lives in a city in the north part of the island of Borneo. He is being managed by a doctor in the Malaysian City of Kuching. Now the doctor caring for this man is married to an Infectious Disease expert and she raises concerns that this might be due to a parasitic disease. She is told by the husband that the disease of which she is thinking is not present in the region. She is not swayed and admits him for nightly blood smears which are negative. She then does a rapid immunochromatographic dipstick test that is positive. He lives in a community outside the city and they go to that village and find others with limb swelling issues who are also positive on antigen testing. He is treated with an antibiotic, not antiparasitic for 4 weeks and the arm improves.  Hint: this is not Wuchereria Bancrofti. Become a patron of TWiP  Send your questions and comments to [email protected] Music by Ronald Jenkees

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• TWiP 254: Our hero Dickson

  TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Click arrow to play Download TWiP #254 (88 MB .mp3, 61 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP  Send your questions and comments to [email protected] Music by Ronald Jenkees TWiP explains a study which finds that tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei, then remembers our departed colleague Dickson Despommier. Hosts: Vincent Racaniello, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Join the MicrobeTV Discord server Tissue spaces are reservoirs of antigenic diversity for T. brucei (Nature) Understanding trypanosome antigenic variation (Emerg Top Life Sci) Tissue resident T. brucei (PLoS Path) Hero – Dickson Despommier Despommier Photo Art Parasitology Course (YouTube) Become a patron of TWiP  Send your questions and comments to [email protected] Music by Ronald Jenkees

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