435. Atrial Fibrillation:Ā Chronic Management of Atrial Fibrillation with Dr. Edmond Cronin
CardioNerdsĀ (Dr. Kelly Arps,Ā Dr. Naima Maqsood, andĀ Dr. Elizabeth Davis) discuss chronic AF management withĀ Dr. Edmond Cronin.Ā This episode seeks to explore the chronic management of atrial fibrillation (AF) as described by the 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation:āÆA Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. The discussion covers the different AF classifications, symptomatology, and management including medications and invasive therapies. Importantly, the episode explores current gaps in knowledge and where there is indecisionĀ regardingĀ proper treatment course, as in those with heart failure and AF. Our expert,Ā Dr. Cronin, helps elucidate these gaps and apply guideline knowledge to patient scenarios.Ā Audio editing for this episode was performed byĀ CardioNerdsĀ intern Dr. Bhavya Shah.
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Pearls
Review the guidelines- CatheterĀ ablation is a Class I recommendation for select patient groupsĀ
Appropriately recognize AF stages-Ā preAFĀ conditions, symptomatology, classification system (paroxysmal, persistent, long-standing persistent, permanent)Ā
Be familiar with theĀ EAST-AFNET4Ā trial, as it changed the approach of rate vs rhythm controlĀ
Understand treatment approaches- lifestyle modifications, management of comorbidities, rate vs rhythm control medications, cardioversion, ablation, pulmonary vein isolation, surgical MAZEĀ
Sympathize with patients- understand their treatment goalsĀ
Notes
Notes: Notes drafted by Dr. Davis.āÆāÆĀ
What are the stages of atrial fibrillation?Ā Ā
The stages of AF were redefined in the 2023 guidelines to better recognize AF as a progressive disease that requires different strategies at the different therapiesĀ
Stage 1 At Risk for AF: presence of modifiable (obesity, lack of fitness, HTN, sleep apnea, alcohol, diabetes) and nonmodifiable (genetics, male sex, age) risk factors associated with AFĀ
Stage 2 Pre-AF: presence of structural (atrial enlargement) or electrical (frequent atrial ectopy, short bursts of atrial tachycardia, atrial flutter) findings further pre-disposing a patient to AFĀ
Stage 3 AF: patient may transition between these stagesĀ
Paroxysmal AF (3A): intermittent andĀ terminatesĀ within ā¤ 7 days of onsetĀ
Persistent AF (3B): continuous and sustained for > 7 days and requires interventionĀ
Long-standing persistent AF (3C): continuous for > 12 monthsĀ Ā
Successful AF ablation (3D): freedom from AF after percutaneous or surgical interventionĀ
Stage 4 Permanent AF: no further attempts at rhythm control after discussion between patient and clinicianĀ Ā
The term chronic AFĀ isĀ considered obsolete and such terminology should be abandonedĀ Ā
What are common symptoms of AF?Ā Ā
Symptoms vary with ventricular rate, functional status, duration, and patientĀ perceptionĀ
May present as an embolic complication or heart failure exacerbationĀ
Most commonly patients report palpitations, chest pain, dyspnea, fatigue, or lightheadedness. Vague exertional intolerance is commonĀ
Some patients also have polyuria due to increased production of atrial natriuretic peptideĀ
Less commonly can present as tachycardia-associated cardiomyopathy or syncopeĀ
Cardioversion into sinus rhythm may be diagnostic to helpĀ determineĀ if a given set of symptoms are from atrial fibrillation to help guide the expected utility of more aggressive rhythm control strategies.Ā Ā
What are the current guidelinesĀ regardingĀ rhythm control and available options?Ā
COR-LOE 1B: In patients with reduced LV function and persistent (or high burden) AF, a trial of rhythm control should be recommended to evaluate whether AF is contributing to the reduced LV functionĀ Ā
COR-LOE 2a-B: In patients with reduced LV function and persistent (or high burden) AF, a trial of rhythm control should be recommended to evaluate whether AF is contributing to the reduced LV function. In patients with a recent diagnosis of AF (<1 year), rhythm control can be useful to reduce hospitalizations, stroke, and mortality. In patients with AF and HF, rhythm control can be useful for improving symptoms and improving outcomes, such as mortality and hospitalizations for HF and ischemia. In patients with AF, rhythm-control strategies can be useful to reduce the likelihood of AF progression.Ā
COR-LOE 2b-C: In patients with AF where symptoms associated with AF are uncertain, a trial of rhythm control (eg, cardioversion or pharmacological therapy) may be useful toĀ determineĀ what if any symptoms are attributable to AF.Ā
COR-LOE 2b-B: In patients with AF, rhythm-control strategies may be useful to reduce the likelihood of development of dementia or worsening cardiac structural abnormalities.Ā
While both rate and rhythm control can improve AF symptoms, several studies (such as AF-CHF) show improved quality of life with rhythm controlĀ
EAST-AFNET 4 was significant in that it showed rhythm control was associated with a 25% reduction in the combined endpoint of mortality rate, stroke, and hospitalizations due to HF or ACSĀ
Acute rhythm control can be achieved with electrical or pharmacological cardioversion. Electrical is more effective and faster than pharmacological and is preferred for patients with hemodynamic instability attributable to AF. However, both approaches involved considerations for anticoagulation and thromboembolic risk. Pharmacologic options for cardioversion includeĀ ibutilide, amiodarone, flecainide, propafenone, procainamide,Ā dofetilide, and sotalol.Ā Ā
COR-LOE 1-A: In patients with symptomatic AF in whom antiarrhythmic drugs have been ineffective, contraindicated, not tolerated or not preferred, and continued rhythm control is desired, catheter ablation is useful to improve symptoms.Ā
AF ablation is also a suitableĀ first-lineĀ optionĀ in some patients with paroxysmal AF to reduce recurrence and burden. Patient selection is important. Younger patients, those with minimal atrial enlargement, less myocardial fibrosis, and less persistent forms are more likely to have successful ablations, meaning less likely to have recurrence of AF after ablation.Ā Ā
HFrEFĀ patients derive greater benefit than others from AF ablation in terms of improved functional status, LV function, and cardiovascular outcomesĀ
Surgical ablation can be considered in those undergoing cardiac surgery for some other etiology such as valve surgery or CABG and is associated with increased survival, but some risk of pacemaker placement and renal dysfunctionĀ
How would youĀ monitorĀ for AF recurrence in post-ablation or cardioversion? Is there a role for monitoring in every patient?Ā
Cardiac monitoring may be advised to AF patients forĀ various reasons, such as for detecting recurrences, screening, or response to therapyĀ
Long-term surveillance to detect recurrent AF can be beneficial and can beĀ accomplishedĀ by various modalities, including wearable devices, smart watches, random monitoring (Holter, event, mobile telemetry), and implantable loop recorders. This is especially helpful in those who had AF-induced cardiomyopathy, especially if their LVEF recovered after rate/rhythm control. This is a population in whom recurrence of AF would want to be promptly noted and addressed.Ā Ā
Loop recorders can also be helpful in detecting subclinical AF or in patients with stroke or TIA of undetermined cause (COR-LOE 2a-B)Ā
What AF burden warrants intervention?Ā
It is important to recognize that AF is a chronic condition and tends to recur, so treatment often is focused on reducing risk of recurrenceĀ Ā
Patient-clinician shared decision making is important when deciding when/how to intervene, as there is no cut-off for āsignificantā burden (COR-LOE 1-B)Ā
What are some options for antiarrhythmic drugs and their characteristics?Ā
Antiarrhythmic drugs are reasonable for long-term maintenance of sinus rhythm for patients with AF who are not candidates for, or decline, catheter ablation,Ā or who prefer antiarrhythmic therapyĀ
Amiodarone can be used inĀ patientsĀ with or withoutĀ HFrEF, as opposed to many other anti-arrhythmicsĀ that areĀ (relatively)Ā contraindicated inĀ HFrEFĀ or should be used with caution in such patients,Ā such as flecainide, propafenone, dronedarone, and sotalol. However, due to its adverse effects and multiple drug interactions, is should be used only in patients in which other antiarrhythmic drugs are contraindications, ineffective, or not preferred.Ā DofetilideĀ can also be used in patients withĀ HFrEF.Ā Ā
In patientsĀ onĀ amiodarone, labs should be checked regularly for thyroid,Ā liverĀ and kidney functions. There is also a role for pulmonary function testing and chest x-rays toĀ monitorĀ forĀ pulmonary fibrosis, but frequency is not clearlyĀ established. It should be noted that amiodarone-induced lung toxicity occurs between 6 months and 2 years of use.Ā Ā
Flecainide is wellĀ tolerated, butĀ is contraindicated inĀ patients with significant coronary artery disease andĀ possiblyĀ structuralĀ heart disease in general. It can also lead to the development of atrial flutter.Ā Ā
DofetilideĀ and sotalol require regular renal function monitoring and QTC monitoringĀ
When should AV node ablation (AVNA) be considered?Ā
In patients with AF and uncontrolled rapid ventricular response refractory to rate-control medications (who are not candidates for or in whom rhythm control has been unsuccessful), AVNA can be useful to improve symptoms and QOL (COR-LOE 2a-B)Ā
AVNA is effective for rate control and does not require continuation of medications;Ā however,
Ireland