Best Of: Finding Dora Richardson: The Forgotten Developer of Tamoxifen, a Lifesaving Breast Cancer Therapy - Episode Two
Although initial clinical trials of tamoxifen as a treatment of breast cancer were positive, Imperial Chemical Industries (ICI) did not believe this market would be commercially viable. The company had hoped for a contraceptive pill – tamoxifen didn’t work for that – not a cancer treatment. In 1972 the higher-ups at ICI decided to cancel the research.But Dora Richardson, the chemist who had originally synthesized the compound, and her boss, Arthur Walpole, were convinced they were on to something important, something that could save lives. They continued the research in secret. Tamoxifen was eventually launched in 1973 and went on to become a global success, saving hundreds of thousands of lives. Dora Richardson’s role in its development, however, was overshadowed by her a male colleague and all but forgotten.This Best Of episode first aired in October 2024 to coincide with Breast Cancer Awareness month. It is now also available in a Spanish adaptation, narrated by Laura Gómez.
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Encontrando a Dora Richardson – La desarrolladora olvidada del tamoxifeno, una terapia vital contra el cáncer de mama
Aunque los ensayos clínicos iniciales del tamoxifeno como tratamiento del cáncer de mama fueron positivos, Imperial Chemical Industries (ICI) no creía que este mercado fuera comercialmente viable. La compañía esperaba una píldora anticonceptiva (el tamoxifeno no funcionó para eso), no un tratamiento contra el cáncer. En 1972, los superiores del ICI decidieron cancelar la investigación. Pero Dora Richardson, la química que originalmente había sintetizado el compuesto, y su jefe, Arthur Walpole, estaban convencidos de que estaban en algo importante, algo que podría salvar vidas. Continuaron la investigación en secreto. El tamoxifeno se lanzó finalmente en 1973 y se convirtió en un éxito mundial, salvando cientos de miles de vidas. El papel de Dora Richardson en su desarrollo, sin embargo, fue eclipsado por su colega masculino y casi olvidado.
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Best Of: Finding Dora Richardson, The Forgotten Developer of Tamoxifen, a Lifesaving Breast Cancer Therapy - Episode One
In the early 1960s, Dr. Dora Richardson synthesized a chemical compound that became one of the most important drugs to treat breast cancer: tamoxifen. Although her name is on the original patent, her contributions have been lost to history.In the first episode of this two-part podcast, Katie Couric introduces us to Dora’s story, and we show how Lost Women of Science producer Marcy Thompson tracked down Dora’s firsthand account of the history of the drug’s development. This document, lost for decades, tells the story of how the compound was made and how Imperial Chemical Industries, where Richardson worked, almost terminated the project because the company was hoping to produce a contraceptive, not a cancer therapy.This Best Of episode first aired in October 2024 to coincide with Breast Cancer Awareness month. It is now also available in a Spanish adaptation, narrated by Laura Gómez.
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Encontrando a Dora Richardson – Episodio 1
A principios de la década de los sesenta, la Dra. Dora Richardson sintetizó un compuesto químico que se convirtió en uno de los medicamentos más importantes para tratar el cáncer de mama: el tamoxifeno. Aunque su nombre aparece en la patente original, sus contribuciones fueron olvidadas por la historia. En el primer episodio de este podcast de dos partes, les contamos la historia de Dora y de cómo Marcy Thompson, productora de Lost Women of Science, rastreó su relato en primera persona sobre el desarrollo del medicamento. Este documento, perdido durante décadas, narra cómo se creó el compuesto y cómo la empresa Imperial Chemical Industries, donde trabajaba Richardson, estuvo a punto de cancelar el proyecto porque buscaba desarrollar un anticonceptivo, no una terapia contra el cáncer.
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Opening Doors to Computer Science
In high school, Carla Brodley was almost shut out of computer science when boys took over all the computers. But she rediscovered her love for the field in college and has made it her mission to open doors for others. At Northeastern University, she founded the Center for Inclusive Computing, which now partners with more than 100 institutions to make computer science more accessible. As a result of Brodley’s push to introduce more flexible degree programs, more women — and especially more women of color — have not only enrolled but stayed in the field. Now, with support from Pivotal, a group of organizations founded by Melinda French Gates, Brodley is aiming to scale up her efforts. Today she joins Lost Women of Science host Katie Hafner to share her journey, new paths to computer science, and how AI fits in.
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For every Marie Curie or Rosalind Franklin whose story has been told, hundreds of female scientists remain unknown to the public at large. In this series, we illuminate the lives and work of a diverse array of groundbreaking scientists who, because of time, place and gender, have gone largely unrecognized. Each season we focus on a different scientist, putting her narrative into context, explaining not just the science but also the social and historical conditions in which she lived and worked. We also bring these stories to the present, painting a full picture of how her work endures.
Ireland