The Beyond Tomorrow Podcast with Julian Issa

What’s the biggest problem in longevity today: bad science, hype, or misplaced optimism?

This episode is brought to you by NADclinic.com, the go-to destination for longevity and human performance. Check out their new NADair, a next-gen, precision breath-activated NAD⁺ wellness system using multi-patented DPI technology: https://nadairx.com/ 

This debate brings together leading voices in longevity to separate evidence from speculation. They discuss why misinformation is growing and why many people chase advanced treatments before addressing basic health.

The panel explores longevity escape velocity, healthspan versus lifespan, and how much progress has actually been made. They debate whether dramatic life extension is near or still much farther away than many believe.

The conversation also examines peptides, NAD+ infusions, longevity clinics, and biological age tests. Along the way, they discuss risk, regulation, incentives, and how to distinguish credible medicine from marketing.

Get to Know the Guests:
Matt Kaeberlein is a biogerontologist and leading aging researcher known for his work on the biological mechanisms of aging and interventions that promote healthy longevity.

Aubrey de Grey is a biomedical gerontologist and longevity advocate best known for developing strategies to repair age-related cellular damage and accelerate progress toward extending healthy human lifespan.

Dr. Brian Kennedy is a renowned aging researcher and former director of the Centre for Healthy Longevity at the National University of Singapore, focused on translating longevity science into real-world health interventions.

Johannes Weiss is the founder and CEO of Longevity Center Vienna, where he focuses on preventive medicine, root-cause health optimization, and personalized longevity strategies. He is an international speaker and practitioner known for combining longevity science, neurofeedback, and mitochondrial health to improve healthspan.

What You’ll Learn
Why misinformation is growing in longevity

Healthspan vs. lifespan vs. longevity escape velocity

Why health basics matter more than longevity hacks

What the evidence says about peptides and NAD+

How to spot credible longevity clinics

Why biological age tests remain controversial

⏱ Timestamps00:00 Intro
00:48 The Most Dangerous Force in Longevity
02:17 Why Longevity Isn't Medicine Yet
07:23 Why Clinical Trials Still Matter
08:15 The Hidden Bias in Longevity Data
09:40 Can You Make Money in Longevity?
10:34 Fix the Basics First 
11:34 The Risks of Peptide Misuse
16:01 Should Doctors Prescribe Peptides?
17:54 When Optimism Becomes Self-Deception 
26:45 The Myth of Billionaire-Funded Longevity
28:38 The Promise and Risk of Mitochondrial Drugs
31:49 Why Truth Matters in Longevity Science
35:28 Can We Cure All Diseases?
38:55 The Future of Personalized Longevity
42:38 How to Spot a Credible Longevity Clinic
48:02 Peptide Red Flags to Watch For
49:42 The Myth of Longevity Shortcuts
52:33 The Misinformation Problem in Longevity 
58:12 The Most Effective Longevity Drug
01:02:37 If Tomorrow Was Your Last Day...

Connect with Matt
Instagram: https://www.instagram.com/mkaeberlein 
LinkedIn: https://www.linkedin.com/in/mkaeberlein 
X: https://x.com/mkaeberlein 

Connect with Aubrey
Linkedin: https://www.linkedin.com/in/aubrey-de-grey-24260b/
Instagram: https://www.instagram.com/aubreydegrey/
X: https://x.com/aubreydegrey

Connect with Johannes
Website: https://johannesweiss.at/ 
LinkedIn: https://at.linkedin.com/in/johannesweiss-longevity 

Connect with Brian
Website: https://medicine.nus.edu.sg/sites/briankennedylab/ 

Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/  
Instagram: https://www.instagram.com/juliankissa/  
LinkedIn: https://uk.linkedin.com/in/julian-issa  
Website: www.beyondtomorrowpodcast.com 
Email: bookings@beyondtomorrowpodcast.com

Can AI help us defeat aging or are we still missing the pieces that matter most?

In this episode, Adam and Nathan explore the growing intersection of AI and longevity. They discuss whether accelerating artificial intelligence could unlock breakthroughs in medicine, or if biology remains too complex for current models to solve.

The conversation breaks down the major approaches to extending human lifespan, from cellular replacement and organ engineering to cryopreservation and partial reprogramming. They examine the promises, limitations, and biggest unanswered questions facing the field today.

The episode also dives into the deeper motivations behind longevity research. From the fear of death and the loss of loved ones to the possibility of a future where aging is optional, Adam and Nathan share why they believe extending healthy human life may be one of humanity’s most important challenges.

About the Guests
Adam Gries is the founder and CEO of Vitalism, a nonprofit dedicated to accelerating progress in longevity and human life extension. He is also the creator of Vitalist Bay, a leading gathering that brings together scientists, entrepreneurs, and investors working to solve aging.

Nathan Cheng is the co-founder and CEO of the Longevity Biotech Fellowship. He is a leading advocate for emerging longevity technologies, helping connect researchers, founders, and investors working to extend healthy human lifespan and accelerate progress in rejuvenation biotechnology.

This episode is brought to you by NADclinic, the go-to destination for longevity and human performance. Check them out at https://nadclinic.com.

What You’ll Learn
Why AI could accelerate longevity research

The most promising approaches to reversing aging

Where current AI tools fall short in biology

Which longevity breakthroughs may arrive first

The opportunities and risks facing the longevity movement

What a future without aging could look like

⏱ Timestamps
00:00 Intro
00:10 AI Could Change Everything
01:16 Most People Misunderstand Longevity
03:28 The Radical Plan to Replace Your Body
07:33 The AI-Longevity Convergence
14:05 Why AI Still Can’t Understand Biology
19:26 The Longevity Gold Rush
22:22 The Next Trillion-Dollar Drug
25:16 The Fear Every Longevity Expert Faces
30:37 The Biggest Myth in Longevity
33:03 When Could Aging Be Solved?
37:36 The Case for Optimism
39:57 The Disaster That Could Set Longevity Back Decades
44:29 A World Without Aging
50:35 What Happens If Death Becomes Optional?
53:11 The Role You Can Play
56:51 Your Race Against Time
01:02:15 If Tomorrow Is Your Last Day...

Follow Adam:
Website: https://vitalismfoundation.org/ 
LinkedIn: https://www.linkedin.com/in/adamgries 
X: https://x.com/adamgries 

Follow Nathan:
Website: https://nathancheng.xyz/ 
Website: https://www.longbiofellowship.org/ 
LinkedIn: https://ca.linkedin.com/in/nathan-cheng-6b464b207 
X: https://x.com/realnathancheng 

Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/  
Instagram: https://www.instagram.com/juliankissa/  
LinkedIn: https://uk.linkedin.com/in/julian-issa  
Website: www.beyondtomorrowpodcast.com 
Email: bookings@beyondtomorrowpodcast.com 

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Joe Betts-LaCroix and Retro Biosciences recently raised funding at a $1.8 billion valuation. In his first podcast appearance since the announcement, Joe shares his vision for extending healthy human lifespan and the breakthroughs driving the longevity industry forward.

Joe Betts-LaCroix explains why aging is becoming a legitimate scientific target. He shares how new discoveries are turning longevity from speculation into measurable biology.

The conversation explores how AI is accelerating research, while highlighting why biology remains one of the hardest problems to solve. Even with smarter models, real-world testing and clinical trials still take time.

Joe also discusses Alzheimer's, partial cellular reprogramming, and the future of longevity medicine. He shares why exercise remains the best longevity tool available today and what the next decade could look like for human health.

Joe is the CEO of Retro Biosciences and a longtime entrepreneur focused on science and technology. His mission is to extend healthy human lifespan and accelerate breakthroughs in aging research.

This episode is brought to you by NADclinic, the go-to destination for longevity and human performance. Check them out at https://nadclinic.com.

What You’ll Learn
Why Sam Altman backed Retro Biosciences

The discovery that changed aging research forever

How AI is transforming biotech and longevity

Why curing all diseases in 10 years is unlikely

What Retro's Alzheimer's programs are targeting

Why biology is harder than most people realize

The longevity intervention Joe recommends today

How aging may become a treatable condition

What the longevity industry could look like by 2030

Joe's vision for the future of human health and AI

⏱ Timestamps
00:00 Intro
00:16 AI's Role in Longevity
03:26 Will AI Cure All Diseases?
09:41 Why Biology Is So Hard to Solve
13:17 Building Technology That Matters
15:06 Adding 10 Healthy Years to Life
18:08 Inside Retro's Clinical Trial
19:31 The Different Types of Longevity Companies
22:10 Are We Already in the Singularity?
24:46 Why Investors Are Betting on AI Biotech
26:15 AI as the New Electricity
27:01 The Biggest Risks Facing Longevity
30:54 Why More Competition Is Good
32:44 Solving Alzheimer's Disease
34:26 Aging Biology and Future Therapeutics
38:25 The Biggest Aging Myth
39:41 The Most Underrated Voices in Longevity
40:25 The Best Longevity "Hack"
46:13 The Future of Longevity by 2030
50:49 If Tomorrow Was Your Last Day...

Follow Joe:
Website: https://www.retro.bio/ 
LinkedIn: https://www.linkedin.com/in/bettslacroix 
X: https://x.com/bettslacroix 

Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/  
Instagram: https://www.instagram.com/juliankissa/  
LinkedIn: https://uk.linkedin.com/in/julian-issa  
Website: www.beyondtomorrowpodcast.com 
Email: bookings@beyondtomorrowpodcast.com 

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Could AI help humanity cure aging and dramatically extend human life?

Artificial intelligence is rapidly transforming medicine and longevity research. Scientists now believe AI could dramatically accelerate drug discovery, personalized healthcare, and treatments for aging itself.

In this episode, Derya Unutmaz explains why he believes humanity could reach “longevity escape velocity” within the next decade. He discusses digital twins, AI-powered drug discovery, superintelligence, and the future of human health.

Derya also explores the risks of advanced AI, arguing that the greatest danger is not the technology itself, but how humans choose to use it.

Derya Unutmaz is an immunologist and longevity researcher whose work focuses on aging, human immunology, and AI-driven biotechnology. His research explores how artificial intelligence could transform disease treatment, lifespan extension, and the future of human health.

This episode is brought to you by NADclinic, the go-to destination for longevity and human performance. Check them out at https://nadclinic.com.

What You’ll Learn
Why Derya believes aging could soon become reversible

How AI is speeding up drug discovery and healthcare

What digital twins could mean for personalized medicine

How AI-powered labs may transform scientific research

The biggest risks and opportunities of advanced AI

Why tools like AlphaFold are changing biology forever

How AI could help prevent disease and extend human lifespan

⏱ Timestamps
00:00 Intro
00:02 Can Humans Live Indefinitely?
02:09 How AI Could Accelerate Longevity
08:09 Why Biology Needs Dynamic Data
12:18 AI-Powered Labs and Robot Scientists
16:36 How AI is Empowering Ordinary People
20:51 Why Humans Not AI Are the Real Threat
25:40 The Possibility of Curing Every Disease
28:43 How AI is Revolutionizing Drug Discovery
35:04 The Biggest Risk Over the Next Decade
40:49 The Economic and Social Impact of AI
46:36 AI, Nuclear Weapons, and Existential Risk
52:53 Why Aging is Humanity’s Biggest Threat
55:06 Do You Fear Death?
56:55 Religion, God, and Human Purpose
58:45 Could AI Become Conscious?
01:00:08 What Happens if Humans Stop Aging?
01:05:29 Why Accelerating Science Matters
01:08:54 Why You Should Embrace AI
01:11:46 Can AI Help Cure Cancer?
01:14:23 The Best Advice for the Future
01:16:48 Never Lose Hope

Follow Derya:
Facebook: https://www.facebook.com/derya/about 
Instagram: https://www.instagram.com/derya_unutmaz_md/ 
LinkedIn: https://www.linkedin.com/in/deryaunutmaz 
X: https://x.com/DeryaTR_ 

Connect with Julian
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/  
Instagram: https://www.instagram.com/juliankissa/  
LinkedIn: https://uk.linkedin.com/in/julian-issa  
Website: www.beyondtomorrowpodcast.com 
Email: bookings@beyondtomorrowpodcast.com 

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Could Cuba become America’s next geopolitical flashpoint?

Cuba remains one of the most politically charged issues in American foreign policy. More than 60 years after the Cuban Revolution, debates around sanctions, regime change, and military intervention are once again intensifying.

In this episode, Mikael Wolfe explains why Cuba is fundamentally different from Venezuela and Iran, and why a U.S. intervention would be far more complicated than many assume. He discusses Donald Trump’s approach to Cuba, the influence of Marco Rubio and Cuban-American politics, and how decades of sanctions have shaped Cuba’s economic crisis.

Mikael also explores Obama-era diplomacy, the growing influence of China and Russia in the region, and whether peaceful political reform in Cuba is still possible without foreign intervention or regime change. Throughout the conversation, he challenges common narratives surrounding democracy, sovereignty, and America’s long relationship with the island.

Mikael Wolfe is a historian, author, and lecturer at the Department of History at Stanford University whose research focuses on modern Latin America, Cuba, environmental history, and U.S.-Cuba relations. His work examines how politics, ideology, and resource conflicts have shaped Cuban society and its relationship with global powers.

This episode is brought to you by NADclinic, the go-to destination for longevity and human performance. Check them out at https://nadclinic.com.

What You’ll Learn
Why Cuba still matters strategically to the U.S.

How Cuba’s system differs from Venezuela’s

Why Florida politics heavily shape Cuba policy

Why a U.S. intervention could happen but fail

How sanctions deepened Cuba’s economic crisis

Why Obama’s Cuba policy briefly changed everything

Whether Cuba can reform without regime change

⏱ Timestamps
00:00 Intro
00:14 Trump’s Intentions for Cuba
02:25 Cuba vs. Iran vs. Venezuela
06:10 Why Cuba Still Matters to the US
10:34 The Politics Behind Regime Change
16:26 Can Cuba Be Compared to Taiwan?
20:23 Chances of a US Military Intervention
24:42 What Happens Over the Next Six Months?
25:46 Why Cuba Could Be the Next Target
28:48 What Happened to “America First”?
31:47 Rubio’s Influence on Cuba Policy
38:04 The Castro Legacy
40:47 Why an Intervention Could Fail
41:33 Cuba’s Deepening Economic Crisis
45:55 Is Cuba Really a National Security Threat?
49:13 What Happens if the US Intervenes?
51:19 Cuba, Iran, China & Russia
53:36 Will Cuba Ever Become Democratic?
57:34 Final Thoughts for the World

Follow Mikael:
Website: https://history.stanford.edu/people/mikael-wolfe 
LinkedIn: https://www.linkedin.com/in/mikael-wolfe-5789952aa 

Connect with Julian:
Instagram: https://www.instagram.com/thebeyondtomorrowpodcast/  
Instagram: https://www.instagram.com/juliankissa/  
LinkedIn: https://uk.linkedin.com/in/julian-issa  
Website: www.beyondtomorrowpodcast.com 
Email: bookings@beyondtomorrowpodcast.com 

Subscribe on Spotify, Apple, and YouTube for more stories from the edge of what is possible.