The Kevin Rose Show

Friends,I recently sat down with Dr. Colleen Cutcliffe, CEO of Pendulum Therapeutics, for a discussion about probiotics, metabolism, and a potential natural alternative to GLP-1 drugs like Ozempic. Here's why I'm excited to share this with you...The BackstoryA month ago, I ran into a friend who had slimmed down and was looking fit. These days, I’ve had a good dozen or so friends lose weight with GLP-1 drugs, so I was surprised when she told me it wasn’t Ozempic but Pendulum's new GLP-1 probiotic. Her chocolate cravings (her usual downfall) had changed entirely. Instead of demolishing a whole bar, she could have one bite and walk away satisfied.I've known Pendulum for years (we invested at True), and I've personally used their glucose control product with great success. However, I had lost touch with Colleen and didn’t realize they had a new GLP-1 product — so I asked her to come on the podcast and discuss it.Note: Peter Attia did a much longer and more thorough deep-dive with Colleen, found hereWhat Makes This Different?In my interview with Colleen, she explained how their probiotic actually helps your body produce its own GLP-1 hormone naturally. The science is fascinating – they've identified specific strains of bacteria that, when delivered to your gut's distal colon, help stimulate natural GLP-1 production. No shots, no prescription.The results are pretty impressive; 91% of users reported reduced food cravings after six weeks*, and the higher the initial cravings, the more significant the improvement.Why This MattersOver the last year+, I've watched friends scramble to find GLP-1 prescriptions, hitting up sketchy compounding pharmacies, or paying astronomical prices when their insurance won't cover them. It's wild out there.But obesity isn't just about weight – it's tied to heart disease, diabetes, cancer, and even cognitive decline (some scientists are calling Alzheimer's "Type 3 diabetes"). We need better solutions that are both accessible and backed by science.Join Our Mini-TrialSadly, the trial is now closed — thanks to all who participated! What's Next?We'll be collecting data throughout the trial and sharing the results with participants. Stay tuned for updates on how the community is progressing.Exciting stuff ahead! As always, I'd love to hear your thoughts and experiences if you decide to participate.Until next time, be well,*based on a consumer survey of 274 people This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.kevinrose.com/subscribe

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Very Important Note:All future episodes of Diggnation will be posted to the official Diggnation channels, not here on the Kevin Rose Show feed. Get your favorite feed (Youtube, Spotify, Apple, RSS) right here on the new website — www.diggnation.showAlso, looking for fun clips? * Diggnation Instagram* Diggnation TikTok This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.kevinrose.com/subscribe

In this inaugural AMA episode of The Kevin Rose Show, Kevin dives deep into personal growth, mental health, and the entrepreneurial journey, sifting through over 100 audience-submitted questions. Joined by his friend Chris Hutchins, the conversation touches on childhood trauma, managing stress, and the balance between building wealth and maintaining personal relationships. Kevin shares candid insights on his therapy practices, including Internal Family Systems (IFS), and provides advice on establishing boundaries, avoiding burnout, and staying creative amidst the chaos of a busy life.Listeners will also get a peek into Kevin’s fitness routine, crypto strategy, and tips on fostering creativity in children. Whether you're looking for actionable advice on entrepreneurship, exploring the future of AI and digital minimalism, or just trying to figure out how to juggle family and business, this episode is packed with raw, honest insights and plenty of wisdom for listeners of all backgrounds. Don't miss this in-depth AMA with Kevin Rose as he tackles life, business, and everything in between.Episode links* Saying No/Proper Boundaries blog post* Carissa Sikora Medium* I Don’t Want to Talk About It* Crucial Conversations* The Anxious Generation* Internal Family Systems (IFS) Therapy* Stillwater (Apple TV show)* Windows Qualcomm Snapdragon ARM-based Laptop* Nothing Ear * SAY Coffee* Madison Reed Hair Dye* Light Phone* Cursor* Chris Hutchins podcast* I checked with Attia’s folks, no concerns about me proceeding with a vasectomy from a hormone or longevity POV. A high-quality doctor is very important (*not health advice; talk to your own doctor).Episode Topics[00:01:24] - What is Kevin's approach to childhood trauma? [00:07:06] - What practices does Kevin use to juggle high stress and long hours? [00:12:09] - How would Kevin build wealth from scratch today? [00:24:33] - What led to Kevin's physical transformation? [00:28:25] - How does Kevin maintain relationships with his wife and kids during travel? [00:30:09] - What traits does Kevin look for in founders when investing? [00:31:32] - What are Kevin's headphone preferences?[00:33:15] - What financial advice does Kevin have for a middle-class family in the Bay Area? [00:35:05] - What's Kevin's next big idea in public markets? [00:37:22] - Would Kevin dye his hair or beard? [00:38:25] - What cultural shifts is Kevin paying attention to? [00:40:03] - What are Kevin's thoughts on education for children? [00:41:20] - What is Kevin's current crypto investing strategy? [00:41:40] - Does Kevin regret promoting NFTs? [00:43:05] - How does AI impact product development? [00:44:26] - How would Kevin balance career and family time in a hypothetical scenario? [00:46:00] - How would Kevin spend a day with no commitments? [00:48:20] - Is Kevin considering a vasectomy? [00:49:05] - What was Kevin's experience with a medium? [00:50:42] - How does Kevin prepare his kids for adulthood? [00:53:13] - Does Kevin ever wish he didn't have the entrepreneur's curse? [00:53:54] - How does Kevin approach introducing technology to his kids? [00:55:27] - How does Kevin choose what to work on? [00:56:44] - What are Kevin's thoughts on saunas? [00:58:10] - What is Kevin's current tech stack? [00:58:40] - How does Kevin like living in a big city again? [01:00:57] - What advice does Kevin have for someone stuck in a high-paying job? [01:02:24] - How does Kevin decide who to take advice from? [01:03:10] - What are Kevin's thoughts on patience versus drive?Thanks for listening; let’s do these every couple of months! This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit www.kevinrose.com/subscribe