Ninja Nerd

• Breast Cancer

  Ninja Nerds,Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Breast Cancer's pathogenesis, risk factors, and the latest advancements in screening, diagnosis, and treatment. We break down the molecular subtypes of breast cancer, including hormone receptor-positive, HER2-positive, and triple-negative disease, and discuss their clinical implications and targeted therapies.Our discussion covers essential diagnostic tools, such as mammography, breast ultrasound, MRI, and core needle biopsy, emphasizing how to interpret imaging findings and pathology reports. We also analyze prognostic factors, including TNM staging, to guide medical therapies.Additionally, we explore cutting-edge treatment strategies, including endocrine therapy, HER2-targeted monoclonal antibodies (e.g., trastuzumab), chemotherapy regimens, and advancements in immunotherapy for triple-negative disease. We also discuss surgical options, radiation therapy, and complications such as lymphedema and cardiotoxicity from trastuzumab.Whether you’re studying for boards, preparing for clinical rotations, or just passionate about oncology, this episode is packed with high-yield pearls you don’t want to miss!Join the Millionaires in Medicine Club!Enjoy the episode and support us below! 🎙🔥Support the show

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• Amyloidosis

  Ninja Nerds,Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Amyloidosis, a complex disorder characterized by the misfolding and deposition of insoluble amyloid fibrils in tissues. We break down the different subtypes, including AL (light chain), AA (secondary), ATTR (transthyretin), and Aβ2M (β2 microglobulin), highlighting their unique pathogenesis, clinical manifestations, and diagnostic approaches.Our discussion covers the systemic vs. localized forms of the disease, exploring how amyloid deposition can impact critical organs like the heart (restrictive cardiomyopathy), kidneys (nephrotic syndrome), nervous system (autonomic and peripheral neuropathy), and gastrointestinal tract. We also walk through essential diagnostic tools, including serum and urine electrophoresis, fat pad biopsy with Congo red staining, mass spectrometry, and advanced imaging techniques like cardiac MRI and PYP scanning for ATTR amyloidosis.Finally, we break down the latest treatment strategies, from chemotherapy and autologous stem cell transplant for AL amyloidosis. Whether you’re preparing for exams, rotations, or just want to master this challenging topic, this episode is packed with high-yield insights to boost your understanding!Enjoy the episode and support us below! 💡🔥Support the show

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• Lymphoma

  Ninja Nerds,Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Lymphoma, breaking down its pathogenesis, clinical presentation, and the latest advancements in treatment. We explore the key differences between Hodgkin and Non-Hodgkin Lymphoma, examining the role of Reed-Sternberg cells, CD markers, and genetic mutations that define these malignancies.Our discussion includes high-yield diagnostic tools like lymph node biopsy, flow cytometry, PET/CT imaging, and molecular studies, helping you differentiate between indolent and aggressive subtypes. We also analyze cutting-edge treatments, including immunotherapy, targeted monoclonal antibodies (e.g., rituximab), chemotherapy regimens like R-CHOP, and the role of stem cell transplantation in refractory cases.Additionally, we cover disease progression, prognostic factors, and complications such as tumor lysis syndrome and secondary malignancies. Whether you’re studying for boards, preparing for clinical rotations, or just love hematology-oncology, this episode is packed with high-yield pearls you don’t want to miss!Enjoy the episode and support us below! 🔬🔥Support the show

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  34:14
• Chronic Leukemias

  Ninja Nerds,Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore Chronic Leukemias, focusing on their pathogenesis, clinical features, and modern treatment strategies. We compare Chronic Myeloid Leukemia (CML) and Chronic Lymphocytic Leukemia (CLL), discussing the role of BCR-ABL in CML and the implications of smudge cells and monoclonal B-cell proliferation in CLL. Our conversation covers key diagnostic tools such as PCR, flow cytometry, and blood smear findings, as well as cutting-edge treatment options like tyrosine kinase inhibitors (TKIs) for CML and targeted monoclonal antibody therapy for CLL. We also discuss disease progression, complications like Richter transformation, and indications for therapy in asymptomatic patients. This high-yield episode is perfect for both exam prep and clinical application—enjoy and support us below!Support the show

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  35:23
• Acute Leukemias

  Ninja Nerds,Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into Acute Leukemias, breaking down their pathophysiology, clinical presentation, and management. We explore the key differences between Acute Myeloid Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL), focusing on the genetic mutations, risk factors, and cellular mechanisms driving these malignancies. Our discussion includes high-yield diagnostic approaches such as peripheral blood smear, bone marrow biopsy, flow cytometry, and cytogenetic analysis. We also cover essential treatment strategies, including induction chemotherapy, targeted therapies, and hematopoietic stem cell transplantation (HSCT), while highlighting critical complications like tumor lysis syndrome and leukostasis. This episode is packed with clinically relevant insights and board exam pearls—tune in and support us below!Support the show

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