Biohacking Beauty: The Anti-Aging Skincare Podcast

Advanced skin treatments often underperform for a reason rarely addressed: regeneration cannot occur in a chronically stressed or under-resourced system. Elevated cortisol, inflammation, and metabolic imbalance weaken collagen signaling and tissue repair before any device, injectable, or modality has a chance to work.
In this episode of the Biohacking Beauty Podcast, we sit down with Joe Radich from R3 Health to unpack why physiological preparation determines treatment outcomes.
We explore how internal factors like stress, hormones, micronutrients, and metabolic health shape skin regeneration, and why modalities like peptides, hyperbaric oxygen, and exosomes only work as well as the system they’re introduced into.
Joe Radich is an NCCPA board-certified Physician Assistant specializing in regenerative medicine and the founder of R3 Health. He trains physicians and mid-level practitioners in stem cells, PRP, exosomes, and biohacking-based clinical protocols, with expertise spanning orthopedic, aesthetic, hair restoration, and regenerative applications.
What's Discussed:
(06:42) Why chronic stress and cortisol are silent drivers of visible skin aging
(10:18) Preparing the body before skin treatments and why physiology determines outcomes
(14:07) Why microneedling success depends on internal biology, not just technique
(18:55) The most common lab patterns behind poor skin regeneration and chronic inflammation
(24:31) Hormonal imbalance vs hormone deficiency and how both affect skin aging
(33:41) GHK-Cu and peptides as signaling tools for connective tissue regeneration
(38:09) Hyperbaric oxygen as a force multiplier for skin repair, recovery, and longevity
(44:06) Exosomes and regenerative biologics and why sourcing and quality determine results
Find more from Young Goose:
VAMPIRE EXOSOMES → Professional Exosome Serum for Regeneration and Post-Treatment Recovery → Vampire Exosomes
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at www.younggoose.com
Instagram: @young_goose_skincare
Winter Skincare Protocol: https://www.younggoose.com/pages/winter-protocol

Find more from Joe Radich (R3 Health):
Website: https://josephradich.com, https://r3health.co
Instagram: @joeradich_

Skin sagging, crepiness, and loss of bounce are often blamed on collagen loss, yet the real driver sits elsewhere in the skin’s architecture. Elastin degradation accumulates quietly over time, shaping how skin functions long before changes fully register in the mirror.
In this Biohacking Beauty episode, we unpack why rebuilding elastin is largely a myth, how elastin breakdown differs fundamentally from collagen loss, and how even a single period of stress can influence skin integrity for decades.
We also examine how collagen is over-credited in conversations about sagging and how lasers and radiofrequency treatments can create temporary tightening while promoting long-term fibrotic remodeling that undermines true elasticity. Tune in.
What's Discussed:
(05:58) Why Elastin, Not Collagen, Drives Skin Bounce and Elastic Recovery
(07:54) Elastin’s 70-Year Half-Life and Why Skin Aging Is Mostly About Preservation
(11:39) Why Rebuilding Elastin Is Largely a Myth After Puberty
(21:10) Why Collagen Loss Is Over-Credited in Skin Sagging
(23:12) Lasers, RF and Fibrotic Remodeling vs True Skin Elasticity
(26:50) The Elastin Enemies: UV, Oxidative Stress, Glycation and Inflammation
(31:39) Preservation Over Correction: Building a Daily Elastin-Protective Strategy
(34:01) Signal-Based Remodeling: Supporting Elastic Function Without Chronic Inflammation
Find more from Young Goose:
VAMPIRE EXOSOMES: Professional Exosome Serum for Regeneration and Post-Treatment Recovery
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at www.younggoose.com
Instagram: @young_goose_skincare
Find our Winter Protocol here: https://www.younggoose.com/pages/winter-protocol
Find our Elastin Action Protocol here: https://www.younggoose.com/pages/elastin-action-protocol-landing

Most conversations about advanced skin treatments stay at the surface, particularly around regenerative approaches, overlooking why lasting results are so hard to achieve.
We dive deeper into this in the latest Biohacking Beauty episode with Dylan Gemelli. We explore why oral peptides often fall short, and how BPC-157 relates to gut healing, inflammation resolution, and collagen repair. We also unpack the real mechanism behind PRP facials, and how neuromodulating peptides compare to Botox over the long term.
Dylan Gemelli is a prominent figure in the fitness and biohacking space and the host of the Dylan Gemelli Podcast. He is currently completing a master’s degree in dietetics and holds certifications as an integrative health professional and cellular health advisor, with his work centered on educating audiences about peptides, longevity, cellular health, nutrition, and neuroscience.
What's Discussed:
(09:07) The real risks of peptides, lack of regulation, and why quality matters
(25:56) BPC-157 beyond athletics: gut healing, inflammation resolution, and collagen repair
(29:44) Why injectable peptides outperform oral and one-off aesthetic treatments
(32:51) Why consistency and loading phases determine peptide results
(37:00) GHK-Cu and why copper peptides matter for skin, hair, and tissue repair
(46:32) Neuromodulating peptides vs Botox and long-term wrinkle prevention
(51:21) PRP facials work because of exosomes, not needles

Find more from Young Goose:
VAMPIRE EXOSOMES → Professional Exosome Serum for Regeneration and Post-Treatment Recovery → Vampire Exosomes
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at www.younggoose.com
Instagram: @young_goose_skincare
Find out everything you need to know about our Winter Protocol here: https://www.younggoose.com/pages/winter-protocol

Find more from Dylan Gemelli:
Website: www.dylangemelli.com
Instagram: @dylangemelli

Ever wonder why your skin changes so much in winter?
In this episode of Biohacking Beauty, we explain what actually happens when humidity drops, TEWL rises and indoor heating pulls moisture from the skin. We also talk about UVA exposure in cold months, lifestyle shifts that increase oxidative stress and why winter puts more pressure on your skin’s repair systems.
We break down the winter ingredients that matter most, like ceramides, barrier lipids, vitamin F, beta glucan, hyaluronic acid, peptides, NAD precursors and exosomes, and how to use them in a routine that supports barrier strength and cellular energy. We also share simple protocol adjustments for different climates and biological skin ages.
If you want a clear strategy for keeping your skin healthy and supported through the colder months, this episode gives you everything you need.
What's Discussed:
(00:36) How Winter Alters Skin Biology and Accelerates Aging
(03:01) TEWL and Barrier Breakdown: Why Skin Gets Drier and More Reactive
(06:26) The Hidden Winter Risk: UVA, Snow Reflection and Daily SPF Needs
(12:47) Glycation, Inflammaging and NAD Decline During Winter
(15:18) Essential Winter Ingredients: Ceramides, Lipids, Vitamin F and Smart Hydration
(21:43) Longevity Actives: NAD Precursors, Peptides, Exosomes and Mitochondrial Support
(28:11) Building the Winter Routine: Climate Adjustments and Repair Protocols
(37:41) Tiered Protocols for Every Age: 30s, 40s, 50s and Beyond
Links Mentioned in This Episode:
Watch our Instagram Reel on Red Light Therapy here!
You can find Young Goose's Winter Protocol here!
Find more from Young Goose:
VAMPIRE EXOSOMES: Professional Exosome Serum for Regeneration and Post-Treatment Recovery
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at www.younggoose.com
Instagram: @young_goose_skincare

What if fine lines, breakouts, and flare-ups are not just skin issues, but the body replaying old experiences it never got to resolve? In this episode, we explore how nervous system patterns, unresolved emotion, and the way we hold stress in the body can quietly shape how our skin ages over time. We look at the skin as a boundary, a canvas, and a reflection of how safe we feel in the world.
We talk with practitioner Eva Hooft about psychosomatics, face mapping, and the cell danger response, and how a chronically dysregulated system keeps inflammation and premature aging on a loop. Eva explains how somatic work can shift bowel function, circulation, and visible radiance, and why she often sees the liver and drainage as the missing link in chronic skin problems. We also dig into mineral balance, heavy metals, community, and why sustainable protocols have to respect both physiology and emotion.
Eva Hooft is a somatic and detox practitioner who combines nervous system work, subconscious reprogramming, and mineral-based detox to help clients unwind chronic symptoms from the inside out. Through group programs, one-to-one work, and education, she guides people to build safety in the body, restore drainage, and release stored burdens so their health and skin can reflect a more regulated state.
We Also Discuss:
(00:54) How Unresolved Emotion Shows Up on the Skin
(08:23) The Cell Danger Response and Chronic Inflammation
(13:25) Somatic Practices That Shift Physical Health
(19:41) Liver Congestion, Bowel Health, and Clear Skin
(24:28) Mineral Balance, Heavy Metals, and Nervous System Stress
(30:27) Community, Safety, and the Biology of Healing
(34:27) Blending Subconscious Work with Detox Protocols
(38:19) Botox, Natural Alternatives, and Sustainable Beauty
Find more from Young Goose:
Vampire Exosomes → Professional Exosome Serum for Regeneration and Post-Treatment Recovery
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://www.younggoose.com/
Instagram: @young_goose_skincare

Find more from Eva Hooft:
Instagram: @eva.hooft
Website: evahooft.com