Episode 69 - I Have No Brain And I Must Test | Thrombophilia Testing
“HATE. LET ME TELL YOU HOW MUCH I'VE COME TO HATE YOU SINCE I BEGAN AS A HAEM REG. IF THE WORD HATE WAS ENGRAVED ON EACH NANO-ANGSTROM OF THE HUNDREDS OF MILLIONS OF CONSULT NOTES I HAVE WRITTEN IT WOULD NOT EQUAL ONE BILLIONTH OF THE HATE I FEEL FOR YOU ORDERING THROMBOPHILIA TESTING INAPPROPRIATELY.” Woah - Let’s calm down, that's a bit much. Cale and Bashar are exposed to Nick’s inner monologue as the Bloody Minded Crew learn about the what, when and when not of thrombophilia testing. TIMESTAMPS0:52 - Nick gets stuck in an anger loop 2:19 - Intro to thrombophilia testing 4:25 - Inherited thrombophilias 5:38 - Surprise historical diversion on antithrombin 8:14 - Proteins C and S 9:31 - Factor V Leiden 10:56 - Prothrombin gene mutation 11:52 - Risk profiles in inherited thrombophilia 18:49 - Acquired thrombophilias 18:56 - Antiphospholipid syndrome 19:46 - PNH 20:22 - JAK2 21:08 - Mid-ep summary 22:28 - The world's biggest soapbox: what not to do 23:25 - Soapbox: no MTHFR pls 25:19 - Soapbox: bad times to test 26:46 - Soapbox: don't test the obvious provoked clots 27:30 - Bonus soapbox: factor V levels vs Leiden 28:54 - When SHOULD we test? 30:41 - Benefits of testing 32:33 - Clinical scenario: spoiler, no real answer 33:26 - Scenarios where you might test 37:49 - Take home messages Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 68 - The Gut Brain Axis | CVST, CRVO, Splanchnic Thrombosis and Other Rare Clots
We're nearly out of pipes to clean - Join us for the world's worst roadtrip we venture into the lesser known parts of human plumbing and tackle unusual site thromboembolism. From splanchnic clots, uterine and testicular thrombi it's clots as far as the eye can see (and those it can't like CRVO!)Timestamps:0:58 - ROADTRIP4:07 - CVST11:07 - CVST - Treatment15:36 - Lemierre's17:50 - CRVO24:36 - Splanchnic Thrombi34:45 - Renal Vein Thrombi39:41 - Uterine Vein Thrombus42:09 - Ovarian Vein44:42 - Testicular Vein46:35 - TakehomesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 67 - Skin Deep | Superficial Thrombophlebitis
It's said that beauty is skin deep but you know what else lurks just under your epithelium - CLOTS! Nick, Cale and Bashar head very slightly under our outer layer to the peripheral vasculature in this increasing tortured metaphor as we learn on our shortest episode to date about what to do when those not so deep vessels fill with thrombus. Timestamps2:12 - Where are superficial veins?5:23 - What's the deal with thrombophlebitis7:34 - MONDOOORS (To the tune of Trogdor)9:11 - Risk Factors for SVT10:56 - Investigations11:53 - Treatment17:54 - SummariesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 66 - In The Lab: D-Lightful | The D-Dimer
D-ismayed by D-readful D-ressing D-owns by your D-emonstrably D-eplorable registrar? . Join de Bloody Minded Crew for a Tour D-Force of D-Dimer D-rama as we D-issect and D-iscuss this most D-ifficult of D-iagnostic tests!Timestamps2:14 - What is a D-Dimer and where does it come from?6:57 - FXIII and D-Dimer7:49 - Fibrinolysis and other degradation products10:18 - D-Dimer Assays - LIA14:22 - D-Dimer Units - Important!15:39 - D-Dimer Assays - ELISA / ELFA16:59 - D-Dimer Assays - POCT18:13 Comparing Assays & Analytical Factors22:12 - D-Dimer Interpretation - Clinical listeners start here!30:16 - D-Dimer and Cancer32:31 - D-Dimer and DIC34:32 - Summary and TakehomesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 65 - Take Your Breath Away | Pulmonary Embolism
“Give me a 2cc bolus of clot stat Emma. No wait - not there!” But it was too late, and Em-Bolused the 2cc of clot straight to the lungs”. Join the Bloody Minded Crew as they get to the heart… no get to the lungs of the topic of Pulmonary Embolism. VanQuish the V/Q and CriTically aPprAise the CTPA with these acronyms that are just as bad as a cardiology trial and half as useful. Sadly the Top Gun soundtrack is copyrighted but nothing will stop you playing Berlin over the background of the intro (and we’d strongly suggest it). Timestamps4:55 - Types of PEs7:14 - Risk Factors for PE8:55 - Signs & Symptoms ft. ECGs12:15 - Investigations21:49 - Vibe Augmenting - Decision Scores25:59 - Brief Recap26:44 - Treatment39:15 - Pregnancy44:35 - Take HomesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs. Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au
Ireland