Episode 61 - On The Wards: BiTE Me and other T Cell Tasty Treats
Have you stumbled onto the haematology ward only to discover patients on bizarrely named BiTE & CART therapy? Why are we giving patients CARTs? Do they come with a horse?Ā Why does everyone freak out when these patients are febrile? Why is everyone so hung up about handwriting? What are these weird drugs?Ā It's OK ā we are here once more to demystify the acronyms ā and help you know what we are giving, why we are giving it and how to manage complications of Bi-Specific and CAR-T therapy!Ā TIMESTAMPS3:48 - Intro to BiTEs Ā 5:26 - Intro to CAR-T Ā 8:27 - Examples of BiTEs Ā 16:36 - CAR-T Collection + Production Ā 18:44 - Examples of CAR-T Products Ā 19:35 - Similarities and Differences between BiTEs and CAR-T Ā 23:24 - Cytokine Release Syndrome (CRS) Ā 30:23 - Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) Ā 39:29 - Treatments for CRS Ā 45:52 - Treatments for ICANS Ā 50:01 - Take Home Messages Ā Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 60 - Twenty Pages About Basophils | Approach to Basophilia
Bamboozled by basophils bountiful booty of granules? Letās begin brilliantly with a basophil based bonanza. Buckets and buckets of brazenly basophil related bonus banter. You beauty! But, beware the bawdy, boisterous boys babbling brobdignagian-ly about BASOPHILS. It sounds better if you read it in Hugo Weavingās voice and itās the 5th of November I swear.Ā TIMESTAMPS3:07 - What are basophils? Ā 6:54 - Snapping turtle trivia Ā 7:55 - Role of basophils Ā 9:42 - Basopenia Ā 10:41 - Cutoffs (arbitrary as usual) Ā 11:14 - Artefactual basophilia Ā 12:29 - Reactive basophilia Ā 14:27 - Haem Causes = MPNs Galore Ā 16:14 - CML (Again) Ā 19:17 - Zebras have hoofbeats too Ā 23:20 - Take Home Messages Ā Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 59 - A Bad (eosino-)Feeling | Approach to Eosinophilia
The mighty eosinophil had triumphed. The last parasitic worm lay vanquished beneath his granule-studded pseudopodia. For years, heād battled helminthic scourge, a hero in mucus armor. But now, with no foes left to smite, he grew restless. He turned his sharp gaze to pollen, peanuts, and pet dander. "Troublemakers," he muttered, unsheathing his cytotoxic arsenal. With righteous zeal, he charged into the sinuses and skin, sparking sneezes and wheals in his wake. āA threat is a threat,ā he declared, as a baffled immunoregulatory system looked on. The worms were gone - but the war had only just begun. With more excerpts leaking from the Bloody Minded Cinematic Universe, itās only a matter of time until our movie deal.TIMESTAMPS2:48 - What are eosinophils? Ā 4:44 - Cutoffs (arbitrary as usual) Ā 7:12 - The Problem with Eosinophilia Ā 8:32 - Infective causes Ā 9:32 - Medications Ā 10:36 - Other Secondary Causes Ā 12:32 - Haem Causes - CML and More Ā 18:08 - Quick Recap Ā 19:49 - Approach to eosinophilia Ā 24:31 - Treatment options Ā 25:52 - Case Study - Not Geraldine, I Promise Ā 28:52 - Take Home Messages Ā Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 58 - Not even my final form | Approach to Monocytes
Put on your monocles and kimonos and hop on the monorail to our episode composed of monotonous monologues, monogamously dedicated to that most monolithic and sometimes monoclonal of mononucleated cells. We are monobviously talking about the monocyte.Ā TIMESTAMPS0:57 - Mono-Cyte! Ā 2:50 - What is a monocyte? Ā 4:20 - Monocyte subclasses Ā 6:00 - Role of monocytes Ā 8:10 - Causes of Monocytopenia Ā 9:43 - Hairy cell leukaemia Ā 12:42 - Reactive monocytosis Ā 15:10 - CMML - Not a Typo Ā 22:20 - Take Home Messages Ā Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 57 - Running on Fumes | Approach to Pancytopenia
Behold the field in which I grow my cells and see that it is barren. Itās out of the frying pan and into the aplastic fire with not a cell in sight. Join Nick, Cale and Bashar without two neutrophils to rub together as we talk about an approach to that most concerning of FBC features - pancytopenia.Ā TIMESTAMPS2:22 - Definition of pancytopenia Ā 4:23 - Spurious pancytopenia Ā 6:04 - Cutoffs (arbitrary as usual) Ā 9:43 - Acquired aplastic anaemia Ā 15:30 - Inherited bone marrow failure syndromes Ā 18:52 - Environmental toxins Ā 19:47 - Medications Ā 20:52 - Haematinic deficiencies Ā 25:59 - MDS/Leukaemias Ā 30:54 - Marrow suppression Ā 33:32 - Infiltrative causes Ā 36:45 - Viral causes Ā 38:05 - Approach to pancytopenia Ā 39:06 - History Ā 40:12 - Examination Ā 41:13 - Investigations Ā 42:27 - Liver failure Ā 44:30 - Take Home Messages Ā Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs. Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au
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