Bloody Minded

They say a picture is worth a thousand words but sometimes there’s only one word you need to know - Lymphoma. Sadly it turns out that’s not enough to pass your morphology exams so join the boys (who have now recovered enough from the trauma of their own examinations to talk about them) and chat about characteristic appearances of lymphoma on the peripheral smear.
TIMESTAMPS
0:52 - Nick gets cultured (not microbiologically)
2:54 - Talkin' bout morphology
4:05 - General principles
6:16 - Normal lymphocytes
7:12 - Reactive lymphocytes
13:00 - CLL
16:45 - Follicular lymphoma
17:43 - Mantle cell lymphoma
19:05 - Marginal zone lymphoma
21:30 - Lymphoplasmacytic lymphoma
24:56 - Hairy cell leukaemia
27:16 - Aggressive B cell lymphomas
29:41 - Myeloma
31:55 - T cell morphology
33:15 - Mycosis fungoides/Sezary syndrome
34:56 - T-LGL
36:10 - T-PLL
39:08 - A-TLL
41:18 - Example cases
45:25 - Weird lymphocyte inclusions
45:58 - Study tips for the morph exam
47:35 - Lol we were not
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

This is getting out of hand, now there are two of them (Dr Nicks). Join the boys as they make a new friend and strongly consider upgrading the house Nicholas to this newer shiny model, and learn a bit about Burkitt Lymphoma along the way!
TIMESTAMPS
 0:57 - **** Is Dead
 9:52 - The immune system as Starcraft units
 11:53 - MYC - The Common Culprit
 17:25 - Subtypes of Burkitts
 19:23 - The Discovery of EBV
 29:04 - Banelings = Spontaneous TLS
 35:25 - Histology of Burkitts
 37:43 - Flow cytometry for Burkitts
 42:47 - Treatment of Burkitts
 47:11 - Differentials for Burkitts
 49:43 - Take Home Messages 
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

The Bloody Minded crew hit the road on a tour of Australia’s big things, and this week’s stop is the biggest of them all: the Big Cell. Joining us as tour guide (and DJ, with an all-Phil-Collins playlist) is Dr Jed Kitson, final-year haematology registrar, here to rescue us from a run of indolent lymphomas and talk about the most common aggressive lymphoma in Australia. From R-CHOP to Axi-cel, from Hans to CNS staging, this is a roadtrip you just can't miss.
TIMESTAMPS
00:56 - The boys take Jed on a roadtrip!
02:47 - Who is this Jed?
03:36 - What IS DLBCL?
05:25 - Classifying DLBCL
07:32 - Epidemiology
08:42 - Presentation of DLBCL
11:03 - Diagnosing DLBCL
14:11 - Pathological features on biopsy
15:58 - Determining cell of origin (COO)
20:03 - DZSig
22:38 - Completing the biopsy examination
23:39 - BCL2, BCL6 and MYC
29:26 - Limitations of FISH
30:36 - Workup in new DLBCL
33:07 - CNS risk
35:17 - Treatment - RCHOP as frontline
37:51 - Trying to improve on RCHOP
43:53 - CNS prophylaxis
45:17 - Assessing treatment response
46:04 - Options in relapsed/refractory DLBCL
48:00 - Options in late relapse
54:00 - Take home messages
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

As Nick once again leaves Bashar and Cale unsupervised they attend Blood 2026 and speak with the finest Australian and New Zealand haematologists in Auckland. They cover a pot pourri of myeloma, iron replacement, HHT, CAR-T, Cheese and mostly lets be honest, garbage. 

Thanks to Dr Georgina Calov, Dr Lise Kempler, Dr Miles Ma, Dr Michel Lu, Dr Alison Chandler for putting up with us and we'll resume our scheduled programming as usual. 
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Look! It’s a follicular lymphoma! No wait, it’s a DLBCL! No wait, it’s a CLL? Actually is it a leukaemia? Join Nick, Cale and Bashar as they wrestle with the morphological and prognostic chameleon that is Mantle Cell Lymphoma. With all the bad bits of an indolent lymphoma and all the bad bits of an aggressive one – as Michael Jackson would say, it's bad (really, really bad). Except when it isn't. Who knows what mantle is doing – we don't think it knows itself
TIMESTAMPS
0:57 - Conspiracies 101
 3:47 - Epidemiology of MCL
 6:41 - Morphology of MCL
 7:41 - Flow cytometry for MCL
 9:16 - Cyclin D1
 14:49 - Risk Stratification for MCL
 17:20 - Ki67 - what is it
 19:15 - MRD for MCL?!
 22:47 - Treatment of MCL
 30:52 - Do we need an autoSCT?
 33:20 - Leukaemic Non-Nodal MCL
 36:27 - Cyclin D1 negative MCL
 37:43 - Take Home Messages
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au