Bloody Minded

Has your ward team been hit with HITT? Is Jane the only Fonda you know? Is BAD an 80s hit and not a trio of anti-coagulation infusions (Bivalirudin, Argatroban and Danaparoid). Is Alison showing her age? Never fear; join Alison, Bashar, Nick and Cale as they aim to de-mystify less commonly used anticoagulation that may come up on the wards. 
TIMESTAMPS
0:56 - It's Fancypants Wednesday!
2:15 - Episode overview
4:37 - Fondaparinux
9:07 - When to use fonda
12:35 - Argatroban
17:25 - When to use argatroban
18:02 - Bivalirudin
19:11 - Mandatory historical diversion
22:50 - Back to bivali business
25:59 - Danaparoid
30:21 - When to use danaparoid
32:45 - Quick summary
34:13 - Dalteparin
38:02 - A bit of nonsense chitchat
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Join us in our third straight week of incredibly nice and incredibly talented haematology gurus as Professor John Moore joins us as an expert guest to discuss stem cell transplant in the myeloid disease setting. 
TIMESTAMPS
 1:00 – HYTTIOAOA
 1:47 – Introducing Professor John Moore
 8:06 – Advice to RMOs on the Allo Term
 11:02 – The history of allogeneic transplantation
 18:26 – Modern morbidity/mortality from alloSCT for AML
 23:05 – Use of transplant scoring systems
 27:29 – The role of MRD in transplant decisions
 30:04 – MAC vs. RIC – Choice of Conditioning
 38:15 – The role of PTCy
 40:17 – Second allogeneic transplants
 42:02 – DLI
 43:08 – Biallelic TP53 – no good options
 45:29 – Free rein in the trials space
 49:11 – AlloSCT/CAR-T for autoimmune disease
 55:05 – Take Home Messages 
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

This week we continue the pattern of guests who are really really ridiculously good at haematology and also really really ridiculously nice people as well. We are very excited to be joined by Dr Michael Krigstein who many of you would know as the a molecular haematology guru who has gotten countless patients through their diagnoses and countless haematology trainees through their exams.
Timestamps:
01:30 - Introducing Dr Michael Krigstein
04:23 - Getting into Lab Haem
08:30 - The Mechanics of NGS
16:57 - Learning to report - RCPA Modules
19:58 - After the NGS - Curation
24:14 - NGS - Not a panacea
28:45 - Why NGS is bad at ITDs
32:42 - Panel Design
36:37 - RNA vs DNA Panels
39:16 - The future of NGS in haematology
46:56 - A standout case
53:36 - Wrapup

Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

What happens when you take someone who is really really ridiculously good at haematology and also a really really ridiculously nice person as well? You get Dr Jad Othman, consultant Haematologist and Haematopathologist at Royal North Shore Hospital in Sydney who will be joining us today to discuss the use of measurable residual disease in acute myeloid leukaemia.
Dr Othman is well suited to this topic, having written his doctoral thesis on molecular disease assessment in AML, sitting on the European LeukaemiaNet (ELN)-DAVID MRD Working Group as well as numerous ALLG AML and MDS working groups. We're delighted to have him field the Bloody Minded Crew's questions today. 
Timestamps
01:00 - The boys making outdated millenial references
02:50 - Getting to know Dr Jad Othman
09:50 - The concept of MRD
11:55 - Lab techniques for MRD
17:59 - Why doesn't everyone have an MRD marker?
20:51 - What makes a good MRD assay?
24:14 - Patients without a molecular MRD marker
26:21 - Clinical case
30:30 - What we do with MRD results
31:47 - The NPM1/FLT3 PB/BM situation
35:31 - Why MRD is actually helpful
39:40 - Why single agent treatment in AML is challenging
44:33 - The 2025 ELN DAVID update
48:44 - Does doing MRD improve OS?
52:21 - The INTERCEPT study
55:41 - Wrap up and summary

Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Here’s a question, what do CD123, CD4 and CD56 have in common? Other than pleasing The Count on Sesame Street. Sorry, another question perhaps - what happens if you cross a plasma cell and a dendritic cell? The answers to these questions can be found on a most enigmatic myeloid cell - the plasmacytoid dendritic cell. And what happens when these rare beasts become neoplastic - why BPDCN of course. Embark on a journey into this weird and not so wonderful (but highly examinable) neoplasm with the Bloody Minded Crew 
TIMESTAMPS
 0:57 – A glimpse into Cale's psyche
 2:39 – Intro to BPDCN
 6:56 – What IS a plasmacytoid dendritic cell?
 10:24 – Pathological PDCs in BPDCN
 11:42 – Clinical presentation – lots of rash talk
 15:23 – Morphology in BPDCN
 17:48 – Immunophenotype
 21:16 – Karyotypic and molecular features
 22:44 – Treatment of BPDCN
 24:00 – A bit on prognostic markers
 25:03 – Transplant
 25:28 – Tagraxofusp
 29:15 – Other treatment options
 31:33 – Take home messages 
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au