Episode 65 - Take Your Breath Away | Pulmonary Embolism
“Give me a 2cc bolus of clot stat Emma. No wait - not there!” But it was too late, and Em-Bolused the 2cc of clot straight to the lungs”. Join the Bloody Minded Crew as they get to the heart… no get to the lungs of the topic of Pulmonary Embolism. VanQuish the V/Q and CriTically aPprAise the CTPA with these acronyms that are just as bad as a cardiology trial and half as useful. Sadly the Top Gun soundtrack is copyrighted but nothing will stop you playing Berlin over the background of the intro (and we’d strongly suggest it). Timestamps4:55 - Types of PEs7:14 - Risk Factors for PE8:55 - Signs & Symptoms ft. ECGs12:15 - Investigations21:49 - Vibe Augmenting - Decision Scores25:59 - Brief Recap26:44 - Treatment39:15 - Pregnancy44:35 - Take HomesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
--------
46:22
--------
46:22
Episode 64 - Never Skip Leg Day | Lower and Upper Limb Venous Thromboembolism
Calves, thighs, arms and more, Clots can form inside them all!Join your hosts Cale, Bashar and Nick as they take a deep (hah) dive into the nitty-gritty things you should know about managing DVTs of the extremitiesTIMESTAMPS0:54 - Intro to Extremity Clots3:49 - Veins of the Lower Limb5:54 - History & Exam Lower Limb10:54 - Phlegmasias15:52 - Investigations21:27 - Below Knee DVTs26:41 - Proximal Lower Limb29:40 - May-Thurner33:04 - PTS34:33 - Upper Limb41:15 - How long to anticoagulate?45:28 - Take HomesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
--------
47:36
--------
47:36
Episode 63 - Virchow’s Revenge | Introduction to Venous Thromboembolism
Rudolf the red nosed physicianWrote a very cool triadAnd if you ever saw ityou would even say ‘Egad!’All of the other physiciansused to laugh and call him dumbThey never let poor Rudolf join in the MDT funThen one foggy clinic daya patient came to say “Rudolf with your triad so smartwon’t you describe to me the pathophysiology of clotting in a way that both makes sense and fits inside the metre of this children's song”But he couldn’t, so welcome back to our next batch of episodes on the pod as we tackle the wonderful world of venous thromboembolism. How do I ask a patient about clots? Is a provoked thromboembolism when you call it names? Join Nick, Cale and Bashar jumping into the wild world of clots...TIMESTAMPS0:58 - Episode Intro2:51 - Crafting a Clot Redux - Haemostasis7:21 - Turbo Coag Cascade8:34 - Thrombosis History12:17 - Why we bother with history16:39 - Risk factors for VTE21:41 - Major vs Minor risk factors23:54 - Thinking about risk factors26:04 - The Thrombosis History32:53 - Management Overview37:40 - Summary and TakehomesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
--------
41:03
--------
41:03
Episode 62 - The Man in the High (Lymph Node) Castle | Castleman Disease
Philip K. Dick once wrote, “Perhaps if you know you are insane then you are not insane. Or you are becoming sane, finally. Waking up.” Waking up, that is, not to the alternative history universe where the Axis won WWII but rather, to a new bonus episode on Castleman disease! Join Cale, Bashar and Nick as we explore one of Haem’s most zebra diagnoses, and do whatever we can to put off Nick’s clot season for just a bit longer.TIMESTAMPS:00:53 - Holiday to Bavaria04:12 - Basics of Castleman Disease07:41 - Histological Subtypes10:57 - Clinical Subtypes - Unicentric13:05 - Clinical Subtypes - Multicentric16:08 - Brief Recap18:00 - Pathophysiology of Castleman21:38 - Historical Diversions23:54 - Investigations25:30 - Treatment - UCD26:44 - Treatment - MCD31:02 - Rarer than a Zebra (POEMS/TAFRO)37:23 - Summary and TakehomesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
--------
39:51
--------
39:51
Episode 61 - On The Wards: BiTE Me and other T Cell Tasty Treats
Have you stumbled onto the haematology ward only to discover patients on bizarrely named BiTE & CART therapy? Why are we giving patients CARTs? Do they come with a horse? Why does everyone freak out when these patients are febrile? Why is everyone so hung up about handwriting? What are these weird drugs? It's OK – we are here once more to demystify the acronyms – and help you know what we are giving, why we are giving it and how to manage complications of Bi-Specific and CAR-T therapy! TIMESTAMPS3:48 - Intro to BiTEs 5:26 - Intro to CAR-T 8:27 - Examples of BiTEs 16:36 - CAR-T Collection + Production 18:44 - Examples of CAR-T Products 19:35 - Similarities and Differences between BiTEs and CAR-T 23:24 - Cytokine Release Syndrome (CRS) 30:23 - Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) 39:29 - Treatments for CRS 45:52 - Treatments for ICANS 50:01 - Take Home Messages Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs. Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au
Ireland