Episode 52 - Scraping the barrel | Approach to thrombocytopenia
Are you a platelet that has been conjugated to an antibody? Sequestered in a spleen? Diluted out by too much saline? Had your precious gold stolen from you? Then you might be entitled to thrombensation! Listen to this episode to learn how we can help YOU approach thrombocytopenia.TIMESTAMPS 2:23 - Striking gold where you least expect it 4:40 - Definition of thrombocytopaenia 8:06 - What do platelets do? 9:22 - History for thrombocytopaenia 12:20 - Exam for thrombocytopaenia 18:03 - Artefactual thrombocytopaenia 21:28 - Decreased platelet production 24:46 - Increased platelet consumption 24:55 - ITP 27:43 - APLS 28:15 - HIT 29:45 - Thrombotic microangiopathies 32:09 - Redistribution/Sequestration 33:41 - Dilutional causes 34:35 - Pregnancy-Related Causes 39:23 - Investigations 42:05 - Platelet Transfusion Thresholds 44:36 - Take Home Messages Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 51 - Seeing Red | Approaching Erythrocytosis
Our half empty cup from last week has now runneth over! If having low red cells is a bad thing, then having an extremely high amount must be a good thing, right? WRONG! Join the Bloody Minded Crew as we explore what happens when we’re on the other side of that Goldilocks zone of red cells. Remember that episode of the Simpsons where they try and force a million germs through a tiny door? It’s like that but in your capillaries.TIMESTAMPS2:14 - Official First Aid Advice 2:30 - Absolute vs. relative erythrocytosis 4:49 - What's the PCV? What's the haematocrit? 7:30 - Signs and Symptoms 10:49 - History for erythrocytosis 14:02 - Causes of Secondary Erythrocytosis 21:30 - SGLT2 Inhibitors - Another Reason to Stop Them 25:36 - Causes of Primary Erythrocytosis 27:20 - Polycythaemia Rubra Vera 29:06 - Budd-Chiari Syndrome 32:20 - Elevated Hb. What Next? 33:48 - Labs - JAK2 + EPO 36:10 - Case Studies - Not Pre-Ordained At All 43:16 - Take Home Messages Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 50 - Washed Out | Approach to Anaemia
All that blood study making you faint, fatigued and short of breath? Well, you might be anaemic but how can we tell why? Join us on our first expedition of this season of highs and lows as we take apart the full blood count one episode at a time. Let’s start with an approach to a cup half-empty of blood - anaemia! TIMESTAMPS2:10 - The Motto of Haematology 3:08 - Definitions - How low is low? 4:24 - MCV is Key 6:43 - TICS and RACH have BLOOD in common 8:47 - TICS(L) - Microcytic Causes 9:27 - Thalassaemia 12:58 - Iron deficiency 19:33 - Chronic disease 22:39 - Sideroblastic anaemia 25:35 - Lead poisoning aka med school fodder 27:46 - RACH - Normocytic Causes 28:01 - Renal Disease 30:32 - Acute blood loss 31:55 - Chronic disease back again 32:18 - Haemolysis - Pls See Season 2 34:46 - (Surprise Myeloma - Pls Also See Season 3) 35:18 - BLOOD - Macrocytic Causes 35:37 - (Except it could be retics) 36:33 - B12 Deficiency 38:43 - Liver Disease 39:16 - etOh 39:54 - fOlate Deficiency 42:04 - Drugs/Dysplasia 43:19 - The red cell maturation pathway 45:28 - Megaloblastic vs. non-megaloblastic 51:09 - Thyroid - might be a thing? 53:03 - What's in an anaemia work-up? 57:05 - Take Home MessagesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 49 - In The Lab: Easy as 1-2-3 | Performing a FBC
Learning to count is hard. Learning to count cells is harder. Luckily we've got an expert with us today to show us the basics. Welcome back to a new batch of episodes where we unpack the highs and lows of haematology and teach you what to do with those pesky out of range blood counts. But to do that we need to know where the numbers come from. We don't know, so we asked Mitchell Rawlings a senior scientist in haematology to come along and relieve of us of our ignorance. Mitch takes us through automated analysers, the principles of cell counting, and some of those mysterious other acronyms on the full blood count. TIMESTAMPS1:25 - A year in review3:09 - Haematology Made Simple4:04 - Everyone deals with FBCs...4:52 - Mitch Rawlings5:48 - God that intro segment was long9:47 - FBC Stats10:19 - Three Letter Acronym Time13:57 - FBC Journey from Vein to Screen15:30 - Analyser Magic16:40 - Coulter principle17:56 - Ghosts in the machine19:40 - The Differential21:25 - Red Flags24:43 - Haemoglobin measurement - productive destruction26:46 - The lab doesn't hate you - please send enough blood28:53 - Retics all day long30:07 - Derived, measured, calculated parameters32:15 - QC + Drift Controls34:06 - Wrong blood in tube36:29 - Platelet counting - citrated, manual counts40:14 - Mixing "studies" - really bad for FBC42:08 - The problem with aspirating clotsSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 48 - On The Wards: HELP! I need somebody! | Consulting Haematology
Have you been asked to call for a Haematology consult and are now considering hiding in a toilet? Never fear! You can listen to this podcast from the hospital bathroom AND learn some fantastic tips and tricks to help us help you! Dr Alison Chandler is back in the studio and we're aiming for future consults with at least 50% less crying – and that’s not just for the Haem AT carrying the consult phone! Timestamps:00:54 - Nick is MIA03:06 - Picking up that phone06:44 - Consult 1) New Thombosis19:50 - Consult 1.1) Superficial Thrombophlebitis22:40 - Consult 2) Deranged Coags31:35 - Consult 3) Cytopenias49:27 - Bonus Consult: Thrombocytosis52:14 - SummariesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs. Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au
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