Episode 71 - Clotting For Good | In The Lab: Thrombophilia Testing II
Come one come all to see the thinnest extended reference in the universe. Draped over not one but TWO episodes, the Bloody Minded Crew continue to make vaguely topical references to popular recent films. Look - we go outside and experience the full gamut of popular culture. Oh and we finish up our discussion of thrombophilia testing in the lab - looking this week at activated protein C resistance testing, molecular Factor V Leiden assessment and Prothrombin gene mutations.TIMESTAMPS1:06 - Pay no attention to the man behind the curtain3:10 - Activated Protein C resistance testing10:27 - Testing in Australia for APCR17:17 - FvL Testing18:51 - PCR - Polymerase Chain Reactions22:52 - Melt curve analysis27:39 - Prothrombin G20210A Testing28:44 - Take Home MessagesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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30:53
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30:53
Episode 70 - The Wizard of Clots | In the Lab: Thrombophilia Testing I
Lions and tigers and… thrombosis? Oh my! Join the Bloody Minded Crew on the yellow brick road to visit the emerald laboratory and see the wonderful wizard of clots - your friendly laboratory coagulation scientist! Put on your blood red ruby slippers and join us for this bumper lab episode as we learn about how exactly we test for Protein C, S and antithrombin deficiencies as well as lupus anticoagulants. By the end of it you’ll have a brain for coags, a heart full of of love for thrombosis and the courage to peer behind the laboratory curtain Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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37:31
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37:31
Episode 69 - I Have No Brain And I Must Test | Thrombophilia Testing
“HATE. LET ME TELL YOU HOW MUCH I'VE COME TO HATE YOU SINCE I BEGAN AS A HAEM REG. IF THE WORD HATE WAS ENGRAVED ON EACH NANO-ANGSTROM OF THE HUNDREDS OF MILLIONS OF CONSULT NOTES I HAVE WRITTEN IT WOULD NOT EQUAL ONE BILLIONTH OF THE HATE I FEEL FOR YOU ORDERING THROMBOPHILIA TESTING INAPPROPRIATELY.” Woah - Let’s calm down, that's a bit much. Cale and Bashar are exposed to Nick’s inner monologue as the Bloody Minded Crew learn about the what, when and when not of thrombophilia testing. TIMESTAMPS0:52 - Nick gets stuck in an anger loop 2:19 - Intro to thrombophilia testing 4:25 - Inherited thrombophilias 5:38 - Surprise historical diversion on antithrombin 8:14 - Proteins C and S 9:31 - Factor V Leiden 10:56 - Prothrombin gene mutation 11:52 - Risk profiles in inherited thrombophilia 18:49 - Acquired thrombophilias 18:56 - Antiphospholipid syndrome 19:46 - PNH 20:22 - JAK2 21:08 - Mid-ep summary 22:28 - The world's biggest soapbox: what not to do 23:25 - Soapbox: no MTHFR pls 25:19 - Soapbox: bad times to test 26:46 - Soapbox: don't test the obvious provoked clots 27:30 - Bonus soapbox: factor V levels vs Leiden 28:54 - When SHOULD we test? 30:41 - Benefits of testing 32:33 - Clinical scenario: spoiler, no real answer 33:26 - Scenarios where you might test 37:49 - Take home messages Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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40:45
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40:45
Episode 68 - The Gut Brain Axis | CVST, CRVO, Splanchnic Thrombosis and Other Rare Clots
We're nearly out of pipes to clean - Join us for the world's worst roadtrip we venture into the lesser known parts of human plumbing and tackle unusual site thromboembolism. From splanchnic clots, uterine and testicular thrombi it's clots as far as the eye can see (and those it can't like CRVO!)Timestamps:0:58 - ROADTRIP4:07 - CVST11:07 - CVST - Treatment15:36 - Lemierre's17:50 - CRVO24:36 - Splanchnic Thrombi34:45 - Renal Vein Thrombi39:41 - Uterine Vein Thrombus42:09 - Ovarian Vein44:42 - Testicular Vein46:35 - TakehomesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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50:35
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50:35
Episode 67 - Skin Deep | Superficial Thrombophlebitis
It's said that beauty is skin deep but you know what else lurks just under your epithelium - CLOTS! Nick, Cale and Bashar head very slightly under our outer layer to the peripheral vasculature in this increasing tortured metaphor as we learn on our shortest episode to date about what to do when those not so deep vessels fill with thrombus. Timestamps2:12 - Where are superficial veins?5:23 - What's the deal with thrombophlebitis7:34 - MONDOOORS (To the tune of Trogdor)9:11 - Risk Factors for SVT10:56 - Investigations11:53 - Treatment17:54 - SummariesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs. Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au
Ireland