Bloody Minded

Does my blood look fat in this?
Does the idea of heparin being a fraction make you wish you listened harder in maths? What is unfractionated heparin? Why are haematologists so judgmental and prefer their anticoagulation low molecular weight? Why does haematology frown when you use the term “blood thinners” ?!?!
If injectable or parenteral anticoagulation feels confusing you have come to the right place! Today we look at unfractionated heparin and low molecular weight heparin,  practical things to think about and how to manage these drugs safely on the wards and beyond 
NB We’re going to leave the advanced injectables like Fonda/Danaparoid/Bivalirudin to a dedicated alternative, probably HITTS themed episode if you’re looking for these drugs

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Twas the night before Christmas, and all through the house, not a creature was stirring, particularly not a missing coagulation factor. Welcome to a very special present all wrapped and delivered by Santa and his Christmas elves and stuffed in your podcast queue in time to drive off for the holidays. Join Cale, a very dusty Bashar, Nick and Santa as we learn a little bit about Christmas Disease. We swear his jacket was that colour before we messed with his haemostatic pathways… CONTENT WARNING: Singing
TIMESTAMPS
00:55 - Pure unbridled musical talent 
03:34 - Intro to Christmas Disease/Haemophilia B
04:58 - History of Haemophilia B
14:01 - Presentation of Haemophilia B
18:25 - Haemophilia B Leyden
22:49 - Coagulation studies in Haemophilia B
26:20 - Treating Haemophilia B
28:12 - Where does factor replacement come from?
31:57 - Inhibitors
33:48 - Gene therapy
37:27 - Take home messages

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

We’ve had one difficult coagulation topic yes, but what about second difficult coagulation topic? We are joined by the fantastic Dr Caroline Dix today to take us through not one but TWO challenging scenarios in thrombosis. First we’ll be revisiting Cerebral Venous Sinus Thrombosis but this time with someone who knows what they are doing. After that we’ll cover anticoagulating people when some very fundamental parts of the system are broken - the management of antithrombin deficiency. This episode wraps up our journey through clots… for now. 
Timestamps:
2:08 - Introducing Dr Caroline Dix
8:03 - CVST - Risks
11:15 - CVST - Clinical
18:08 - CVST - Duration
21:05 - Antithrombin Deficiency
25:12 - Antithrombin Deficiency - Diagnosis
29:43 - Antithrombin Deficiency - Management
37:34 - Wrapup
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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Sometimes something comes along that puts a chill down the spine of every doctor. Any conversation that starts with "Oh hey do you remember that patient you saw...?". Mystery meat day in the cafeteria. Dealing with hospital executives. For these times in life you need a guide. Today we'll be covering one of those spine-chilling clinical scenarios with our very apt guide consultant haematologist Dr Sara Ng. Over forty minutes Sara will un-chill your spine with her practical approach to managing thrombosis when there just aren't that many platelets to go around, as well as talking about conditions where clots and thrombocytopenia are intimately linked.
Timestamps: 
2:11 - Introducing Dr Sara Ng
7:18 - Case 1: Acute PE and Thrombocytopenia
14:55 - Case 1.5: Subacute PE and Thrombocytopenia
18:20 - Case 2: Line Thrombus during Chemotherapy
22:09 - Thrombosis in ITP
26:15 - Oh no a STEMI
27:44 - Two sides of the same coin
31:58 - How 2 4T Score - HITS
35:15 - Other PF4 Antibodies
38:33 - Wrap up & Takehomes

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Come one come all to see the thinnest extended reference in the universe. Draped over not one but TWO episodes, the Bloody Minded Crew continue to make vaguely topical references to popular recent films. Look - we go outside and experience the full gamut of popular culture. Oh and we finish up our discussion of thrombophilia testing in the lab - looking this week at activated protein C resistance testing, molecular Factor V Leiden assessment and Prothrombin gene mutations.
TIMESTAMPS
1:06 - Pay no attention to the man behind the curtain
3:10 - Activated Protein C resistance testing
10:27 - Testing in Australia for APCR
17:17 - FvL Testing
18:51 - PCR - Polymerase Chain Reactions
22:52 - Melt curve analysis
27:39 - Prothrombin G20210A Testing
28:44 - Take Home Messages
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au