Bloody Minded

What do you call a small B-cell lymphoma that isn't CD5 positive, isn't CD10 positive and generally refuses to wear any of the usual hats? Probably marginal zone lymphoma. Possibly. Maybe.
Join the Bloody Minded crew as we head to the edge of the follicle where the bloodstream's customs officers live, and look at what happens when they go rogue. Discover how to cure a cancer with a PPI, and why we're so very bored of the NF-κB pathway.
TIMESTAMPS
0:57 - Whisky sponsorship pls and thx
2:11 - What the marginal zone is/isn't 
6:28 - Marginal zone B cells
8:35 - Classifying marginal zone lymphoma
11:05 - Epidemiology
12:09 - Pathophysiology in gastric MALT
16:42 - Stimuli for other marginal lymphomas
19:55 - Pathological features of marginal
21:20 - Splenic MZL
25:43 - Flow cytometric features
30:13 - Workup of MZL
32:20 - Management strategies
37:53 - Prognosis
38:56 - High grade transformation
40:07 - Take home messages
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Join the boys as they frollickular through the molecular and macro-cular particulars of follicular lymphoma this week. While you're at it, please sign our petition to allow Bashar back into the aquarium and take a gander at Cale's tiny hands.
Timestamps
00:52 - Bashar is banned from the Aquarium a second time
02:13 - Follicular Lymphoma Overview
06:07 - Pathophysiology of FL
09:50 - Follicular Lymphoma In Situ (Old Name)
11:54 - Clinical & Morphology
17:24 - Identifying FL in the Lab
20:08 - Staging & Workup
23:07 - Prognostication
25:56 - To treat or not to treat?
29:31 - Treating Upfront
33:59 - Treating Relapse
37:43 - Transformation
41:12 - Summary
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Why do haematologists get excited over smudges on a film? What is the deal with that whole IGHV situation? Why is Bashar no longer welcome at the zoo? Join us as we find the answers to these common haematology questions and more in a foray into Chronic Lymphocytic Leukaemia!
TIMESTAMPS
0:55 - No animals were harmed in the making of this bit
 4:13 - Epidemiology of CLL
 5:56 - Pathophysiology of CLL
 11:42 - MBL
 12:36 - SLL
 15:54 - Clinical features of CLL
 18:18 - Lab features of CLL
 20:50 - Flow cytometry for CLL
 23:46 - Staging of CLL
 25:38 - Prognostication of CLL
 27:38 - Indications for treatment in CLL
 31:04 - Treatment approaches for CLL
 41:53 - Response assessment in CLL
 42:49 - Richter's transformation
 44:47 - Take Home Messages

Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Welcome to the Land of the Lymphoid. Eighty-odd subtypes, one grid. Help us break our cellular pathways and journey further into our lymphoid season as we ask the only two questions that matter - B or T, fast or slow, forget the platypuses - and build the framework we'll be filling in for the rest of the series. Bring a hat, the savannah is hot. 
0:52 - Lymphoid Planet
2:50 - Leukaemia vs Lymphoma
4:51 - Two Questions & A Recap
8:49 - Identifying a Cell
16:22 - Indolent vs Aggressive (and Super-Aggressive)
22:37 - Indolent B-Cell
23:21 - Aggressive B-Cell
25:27 - Indolent T-Cell
25:44 - Aggressive T-Cell
27:42 - Wait... what about Hodgkins
31:28 - A Framework
32:21 - General Lymphoma Workup
38:19 - Staging
40:12 - Review

Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

For the first time, Cale, Nick and Bashar have managed to maintain a contiguous thought across two different episodes and are returning to school - for the basics of immunology. But they’re not going back as teachers, no, the boys are going undercover as a naïve B-cell and following the journey to the lymph node. Will they be shunned to the uncool table like they were in high school? Can they avoid the murderous hunger games of the dark zone. Will they switch classes or somatically hypermutate? Find out on the next episode of 21 Ju… Lymph Node Street.
TIMESTAMPS
 0:53 - Disguise 101
 5:10 - Naive B cells journey
 7:56 - Lymph node anatomy refresher
 13:31 - Activation of naive B cells
 18:50 - Class switching
 21:38 - Into the dark zone
 24:45 - Diseases at the various stages of maturation
 27:18 - Take Home Messages 
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au