Bloody Minded

Nick wanted to talk about buckets all episode. I’ve convinced him to at least let us get angry at iron polymaltose, hypophosphatemia and nangs all over again. You don’t think you need this episode but you’d be amazed how many consults come through to Haem thinking we’re the gatekeepers of iron in the building. Ironic, really.
TIMESTAMPS
0:56 - 1960s pop culture reference
3:20 - Episode overview
4:40 - Iron deficiency
6:28 - Pica chat
7:53 - Presentations of iron deficiency
8:36 - Causes of iron deficiency
11:10 - Taking a menstrual history
12:53 - Non-menstrual causes of iron deficiency
14:40 - Oral iron replacement
18:19 - IV iron replacement
25:01 - Folate deficiency
27:18 - Folate replacement
29:18 - B12 deficiency
31:19 - Causes of B12 deficiency
32:00 - Diagnosis of B12 deficiency
32:55 - B12 replacement
34:58 - Dealing with concurrent deficiencies
36:20 - Take home messages
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

On the Ning Nang Nongs where the youths smoke bongs and the marrow all screams HELP! Join the Bloody Minded crew as they go through the round window, follow B12 and folate around the body in a Nang induced haze, presumably just like the writers on Play School once were. 
Mandatory viewing: https://www.youtube.com/watch?v=3SUU1f3Mgpc&list=RD3SUU1f3Mgpc&start_radio=1
TIMESTAMPS
0:53 - A Bloody Minded After School Special
1:50 - Megaloblastic Anaemias
2:59 - An Intro to B12
7:49 - B12 Absorption
12:55 - Role of B12
15:07 - MMA + Homocysteine
16:40 - Causes of B12 Deficiency
20:04 - Nangs - Again
23:18 - Intro to Folate
25:32 - Folate Absorption
27:03 - Folate Deficiency
30:00 - Concurrent B12 + Folate Deficiency
32:18 - Take Home Messages
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Heal with steel? Absolutely not - There’s no alloys or for that matter surgeons allowed in the safe space of the laboratory. Join us on another wonderful lab adventure as Bashar, Cale and Nick head down to the biochemistry lab to work out exactly how our iron studies are performed in the lab before you throw the serum iron in the bin.
TIMESTAMPS
0:53 - An early etymological diversion
2:53 - Serum iron
9:43 - UIBC
11:22 - TIBC
13:34 - Transferrin
15:45 - Transferrin saturation
17:25 - Ferritin
20:42 - Example of how the numbers work
23:31 - The iron stain
25:02 - Take home messages
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Taunted by transferrin? Befuddled by ferritin? Scratching your head at why we throw the serum iron results directly into the confidential waste bin, which is a more dignified burial than it deserves? Come along as the boys discuss the interpretation of iron studies in a definitely tight, definitely 20ish minute episode.
Timestamps
00:54 - Just Iron Studies with No Nonsense
02:21 - Overview of Iron Stuides
03:42 - Serum Iron
05:35 - Transferrin
07:32 - TIBC
08:35 - UIBC
10:47 - Transferrin Saturation (TSat)
12:38 - Ferritin
14:34 - Soluble Transferrin Receptor (sTfR)
15:45 - Invasive Iron Studies
16:52 - Rapid Fire Case Studies ft. Geraldine
22:25 - Summary & Take Home Messages
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

One molecule to rule them all, one molecule to find them. One molecule to bring them all, and in the liver bind them. Hepcidin is the key to understanding iron metabolism and we examine how iron gets into, around and out of the body. We promise not to be too Celebrimbor-ing as you join Nick, Cale and Bashar  for this discussion of the basic science of iron handling in preparation for our journey into the building blocks of blood. Welcome to Lord of the Haematinics. 
TIMESTAMPS

0:56 - The next arc of the Bloody Minded Cinematic Universe
3:23 - Series overview
6:21 - Basic iron metabolism
7:54 - The three main player groups in iron metabolism
8:44 - Iron binding molecules: Heme
13:22 - Non-heme iron
14:05 - Iron binding molecules: Ferritin
17:12 - Iron binding molecules: Transferrin
20:44 - Iron transporters: DMT1
25:02 - Iron transporters: ferroportin
28:21 - Iron transporters: Hephaestin
29:28 - Iron flux
33:24 - Hepcidin: Master Regulator and The One Ring
39:04 - Non-hepcidin regulation of Ferroportin and IREs
41:32 - Take home messages
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au