Bloody Minded

It’s the heaviest matter of haematology as we look at the role of heavy metals in our favourite metalloenzymes. What - you don’t have a favourite metalloenzyme?  But nothing else matters?! Anyway, this is no esoteric surgical content, join us as Nick, Cale and Bashar get comfy with the weirder parts of the periodic table and how they apply to less common deficiencies or toxicities in haematology. Look we’ll be honest with you - this is pretty low yield listening but it was fun, and really isn’t that point at the end of the day. 
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Is it a giant Cthulu-esque sea monster? Is it an excellent Australian parody breakfast show? No - it’s everyone’s favourite (well everyone who counts) coagulation related Vitamin - Vitamin K! Where does it come from? Why is it so hard to find on the eMR when you want to prescribe it and what is it doing under phytomenadione? Can we test for it? After listening to Nick, Cale and Bashar wax lyrical about carboxylation for half an hour you’ll be ready to vitamin K-nock yourself out
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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Four humours in balance, the ancients decreed -
so open a vein, let the bad blood be freed.
From Galen to Harvey, from humours to genes, 
From black bile and phlegm to the things on our screens.
From PML::RARA to blood counts okay 
Let’s celebrate our specialty - we’ve come a damn long way

Join us as we travel from the first man to see a red cell, to the first to give people arsenic on purpose who was actually well-intentioned! Pour one out for Galen who was confidently incorrect for fifteen centuries but everyone just went with it anyway because it seemed pretty good at the time. We interrupt your scheduled haematinic programming for a historical grab bag and some chat about the podcast as we celebrate 100 episodes and still going strong. 

TIMESTAMPS
1:49 - Sappy Stuff
7:15 - In the Beginning
9:52 - Leeches
12:57 - Harvey
14:43 - Microscopes
16:08 - Leukaemia
18:11 - Transfusion
20:30 - Anticoagulants
22:55 - Molecular
27:23 - Chemo
29:34 - Transplant
31:07 - Coags
33:07 - CAR-T
35:11 - Wrapup
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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Two vitamins survived the great B-numbering cull to become the tests we order most and trust least. Meet the 80% of your B12 result your cells can't touch, and the antibody that sabotages the very test built to catch it. Join the Bloody Minded Crew as we come to the lab for a second time this season to learn how B12 and folate assays are performed. 
TIMESTAMPS
0:55 - The boys check out a new lab
 2:25 - Episode overview
 3:43 - Sample requirements
 4:12 - B12 refresher
 6:03 - Total B12 assays
 9:36 - Caveats in interpretation
 14:00 - Active B12
 15:59 - MMA and Homocysteine
 18:13 - Folate testing
 22:18 - Take home messages
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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

‘This bad boy can fit so much iron in it’ he said slapping the roof of a badly photoshopped molecule of apoferritin superimposed on a car. Is too much ferritin bad for you? Of course it is - too much is precisely the quantity that is in excess. But most of the time hyperferritinaemia has nothing to do with iron overload. Strap in to your 1992 Honda Civic as the Bloody Minded Crew learn all about ferritin, and why most of the time too much of it has nothing to do with your iron levels at all. Also join Cale specifically as he continues his vendetta against hepatology and their referrals. 
Timestamps
0:59 - Bashar visits the salon
2:03 - Hyperferritinaemia overview
3:13 - Ferritin vs Iron Overload
6:08 - Signs and Symptoms associated with Hyperferritinaemia
10:50 - Causes of Hyperferritinaemia w/o Iron Overload
16:59 - Hyperferritinaemia w/ Iron Overload
21:30 - Chelation
22:43 - Erythoferrone
24:16 - Summary
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au