Bloody Minded

The Bloody Minded crew hit the road on a tour of Australia’s big things, and this week’s stop is the biggest of them all: the Big Cell. Joining us as tour guide (and DJ, with an all-Phil-Collins playlist) is Dr Jed Kitson, final-year haematology registrar, here to rescue us from a run of indolent lymphomas and talk about the most common aggressive lymphoma in Australia. From R-CHOP to Axi-cel, from Hans to CNS staging, this is a roadtrip you just can't miss.
TIMESTAMPS
00:56 - The boys take Jed on a roadtrip!
02:47 - Who is this Jed?
03:36 - What IS DLBCL?
05:25 - Classifying DLBCL
07:32 - Epidemiology
08:42 - Presentation of DLBCL
11:03 - Diagnosing DLBCL
14:11 - Pathological features on biopsy
15:58 - Determining cell of origin (COO)
20:03 - DZSig
22:38 - Completing the biopsy examination
23:39 - BCL2, BCL6 and MYC
29:26 - Limitations of FISH
30:36 - Workup in new DLBCL
33:07 - CNS risk
35:17 - Treatment - RCHOP as frontline
37:51 - Trying to improve on RCHOP
43:53 - CNS prophylaxis
45:17 - Assessing treatment response
46:04 - Options in relapsed/refractory DLBCL
48:00 - Options in late relapse
54:00 - Take home messages
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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

As Nick once again leaves Bashar and Cale unsupervised they attend Blood 2026 and speak with the finest Australian and New Zealand haematologists in Auckland. They cover a pot pourri of myeloma, iron replacement, HHT, CAR-T, Cheese and mostly lets be honest, garbage. 

Thanks to Dr Georgina Calov, Dr Lise Kempler, Dr Miles Ma, Dr Michel Lu, Dr Alison Chandler for putting up with us and we'll resume our scheduled programming as usual. 
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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Look! It’s a follicular lymphoma! No wait, it’s a DLBCL! No wait, it’s a CLL? Actually is it a leukaemia? Join Nick, Cale and Bashar as they wrestle with the morphological and prognostic chameleon that is Mantle Cell Lymphoma. With all the bad bits of an indolent lymphoma and all the bad bits of an aggressive one – as Michael Jackson would say, it's bad (really, really bad). Except when it isn't. Who knows what mantle is doing – we don't think it knows itself
TIMESTAMPS
0:57 - Conspiracies 101
 3:47 - Epidemiology of MCL
 6:41 - Morphology of MCL
 7:41 - Flow cytometry for MCL
 9:16 - Cyclin D1
 14:49 - Risk Stratification for MCL
 17:20 - Ki67 - what is it
 19:15 - MRD for MCL?!
 22:47 - Treatment of MCL
 30:52 - Do we need an autoSCT?
 33:20 - Leukaemic Non-Nodal MCL
 36:27 - Cyclin D1 negative MCL
 37:43 - Take Home Messages
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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

What do you call a small B-cell lymphoma that isn't CD5 positive, isn't CD10 positive and generally refuses to wear any of the usual hats? Probably marginal zone lymphoma. Possibly. Maybe.
Join the Bloody Minded crew as we head to the edge of the follicle where the bloodstream's customs officers live, and look at what happens when they go rogue. Discover how to cure a cancer with a PPI, and why we're so very bored of the NF-κB pathway.
TIMESTAMPS
0:57 - Whisky sponsorship pls and thx
2:11 - What the marginal zone is/isn't 
6:28 - Marginal zone B cells
8:35 - Classifying marginal zone lymphoma
11:05 - Epidemiology
12:09 - Pathophysiology in gastric MALT
16:42 - Stimuli for other marginal lymphomas
19:55 - Pathological features of marginal
21:20 - Splenic MZL
25:43 - Flow cytometric features
30:13 - Workup of MZL
32:20 - Management strategies
37:53 - Prognosis
38:56 - High grade transformation
40:07 - Take home messages
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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Join the boys as they frollickular through the molecular and macro-cular particulars of follicular lymphoma this week. While you're at it, please sign our petition to allow Bashar back into the aquarium and take a gander at Cale's tiny hands.
Timestamps
00:52 - Bashar is banned from the Aquarium a second time
02:13 - Follicular Lymphoma Overview
06:07 - Pathophysiology of FL
09:50 - Follicular Lymphoma In Situ (Old Name)
11:54 - Clinical & Morphology
17:24 - Identifying FL in the Lab
20:08 - Staging & Workup
23:07 - Prognostication
25:56 - To treat or not to treat?
29:31 - Treating Upfront
33:59 - Treating Relapse
37:43 - Transformation
41:12 - Summary
Support the show
Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au