Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the...
Episode 37 - Red Cell Matchmaking | Group and Hold, Antibody Screen, Crossmatch
It’s an early trip to the lab this season to explore exactly how we safely match the blood in the bank to the patient on the ward. Follow your trusty hand-labelled group-and-hold tube as we unpack what actually goes into blood grouping, antibody screening and the final hurdle, the crossmatch!Timestamps0:52 - Nick lives in squalor, surprising nobody2:56 - The Group4:22 - The Forward Group6:53 - The Reverse Group10:55 - The Antibody Screen18:12 - DAT vs IAT20:39 - The Crossmatch25:08 - Anamnestic Antibody Responses27:58 - Phenotyping30:25 - Episode SummaryCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 36 - What’s in the bag, Somerset, what’s in the bag? | Blood Products
We’re back again to answer all of your questions- what’s exactly is a "unit" of blood and how do we go about giving it? What on earth is the difference between FFP and ELP and cryodepleted plasma? And what do each of them sound like, if you were to interpret them via a completely unnecessary collection of household objects? As always, we’ve got you covered.Timestamps:00:55 - Bashar's special presentation03:42 - Where do we get blood from?05:53 - Packed Red Blood Cells (PRBC)08:20 - When and how to transfuse PRBC11:07 - Clerical checks13:02 - Platelets18:12 - Plasma products18:32 - Fresh Frozen Plasma (FFP)20:00 - FFP vs ELP24:00 - Cryodepleted plasma25:10 - Cryoprecipitate27:24 - Albumin28:15 - Fractionated clotting factors29:07 - Immunoglobulins31:12 - Leukocyte tranfusion34:57 - Reducing transfusion-transmitted infection38:00 - Take home messagesCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 35 - The Other Resus | Introduction to Blood Groups
We’ve been out of line with the rest of #FOAM #MedEd podcasts for the longest time. Forget that haematology stuff, it’s time to talk about RESUS. Break out your adrenaline, it’s time to crack some chests and… wait what? You meant Rhesus? With an H? Oh right… okay. Put down those trauma shears as the only thing we’ll be cracking open are the ISBT Red Cell Immunogenetics guidelines. Join the Bloody Minded Crew take you though the basics of blood grouping with a focus on ABO and Rhesus. Timestamps:0:56 - Cale needs help with the target3:00 - Intro to blood groups6:02 - What is a "blood group?"8:40 - Historical diversion on blood groups!9:47 - Cale speaks flawless German13:49 - The ABO group: the hatted and the hatless18:12 - The Bombay phenotype! No hat, no hair.20:38 - ABO frequencies21:11 - ABO compatibilities21:49 - Interesting (to us) ABO tidbits24:43 - Intro to Rhesus29:13 - Nomenclature - RhD, C, c, E, e36:27 - Wiener classification (brace yourself)46:27 - Take home messagesCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 34 - On the Wards: I would do anything for blood – but I won’t do that | Transfusion Reactions
Do you fear – The Power of Blood? Have you been warned – You can’t Hurry Blood? Today we tackle all the ways Blood (and love) can go wrong. . . and how to manage it on the wards.Too cryptic? Join Bloody Minded's own consultant haematologist Dr Alison Chandler and the rest of the Bloody Minded Crew as we cover the many and varied reactions patients can have when you try and fix that haemoglobin level on the ward. Timestamps00:53 - 3-4 nerds chatting about nonsense03:37 - Your first transfusion reaction05:08 - What is a transfusion reaction?5:52 - Categorising transfusion reactions7:26 - Acute febrile reactions17:20 - Summary of acute febrile reactions17:45 - Acute non-febrile transfusion reactions22:11 - Workup and management of an acute reaction37:44 - Delayed febrile reactions50:08 - Delayed non-febrile reactions53:46 - SummariesCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
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Episode 33 - CAR-T and Chromothripsis | Multiple Myeloma Review with Dr Christian Bryant
Myeloma beware, it's time to bring out the big guns. We are incredibly thankful to be joined by a peak predator of plasma cells, Dr. Christian Bryant. He is a consultant Haematologist at RPA in Sydney, has a PhD on the immunology of myeloma and is driven by a passion to improve the treatment and understanding of all things myeloma.TIMESTAMPS2:18 - Intro to Christian Bryant3:05 - Why Haematology?5:31 - Why (oh god why) myeloma?7:28 - Heavy metal, heavy chains9:28 - Chromothripsis - The Cause That Breaks The Camel's Back?13:45 - In praise of plasma cells18:38 - Genomics to risk-stratify precursor states - should we bother?20:32 - Predicting response and high risk disease21:43 - IMS Criteria - High Genomic Risk28:22 - Response Kinetics - When are you nervous?31:31 - Balancing maintenance Len vs. secondary malignancies39:34 - Other agents for maintenance?44:44 - CAR-T - A New Hope?49:10 - T cell exhaustion50:21 - What are the CAR-T target molecules for MM?53:27 - Any hope for a cure?57:35 - MRD MattersCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au
Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs. Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au
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