Another in our series of Themed Podcasts focussing on GU Oncology in China. We are joined by our China Editor, Dr Yao Zhu (Fudan University, Shanghai), and Prof Xuedong Wei (Soochow University, Jiangsu). to find out what the current treatment landscape is for mHSPC in China. Is it ADT/ARPI doublets for all?? Anyone still give chemo? Who gets a PSMA PET/CT? And what is the current status and role for radioligand therapy at progression? Plus, when are we taking GU Cast to Chin again?! All this and more! Thanks to our Gold Partner, Bayer China, for supporting our China Themed Episode Series, and for supporting all our GU Cast Conference Highlights. Even better on our YouTube channelÂ
-------- Â
35:40
--------
35:40
UPDATED - The definitive PSMA systematic reviews!
Those two gigantic PSMA review papers in European Urology - Perera et al 2016 and Perera et al 2020 - have been cited more than 2000 times and have been the definitive reference for anyone writing about PSMA PET/CT in the past ten years. And they have just been updated in two new papers just published in European Urology! Previous first author (Marlon) Perera, has moved to senior author, while Elio Mazzone has led both papers as first author, co-ordinating a massive effort between research teams in Melbourne and Milano. One paper is focused on diagnosis and staging, and the other on assessment of recurrence. GU Cast co-Hosts Declan Murphy and Renu Eapen are joined from Milano by Elio Mazzoni and Alberto Briganti, and in studio by Marlon Perera, to summarise some of the key findings, and describe the immense effort which went into these papers. Worthy successors to the Perera et al papers of the past! Even better on our YouTube channelLinks:Paper 1: PSMA PET/CT for diagnosis and staging Paper 2: PSMA PET/CT for recurrence
What is Histolog?? Well, now that intra operative margin assessment is a such a hot topic in prostate cancer surgery after the Neurosafe RCT read-out, we thought we would dive into one of the other new technologies for doing something similar, but without the pragmatic challenges of frozen section. The idea is to assess the surgical margin of the prostate at the time of surgery to improve nerve sparing and sexual function for patients.We are joined by Professor Greg Shaw (University College London, UK), PI of the Neurosafe Proof trial, which we already featured following their Lancet Oncology paper in March 2025, and our colleague Professor Nathan Lawrentschuk (Peter MacCallum Cancer Centre, AUS), who is leading a study of the Histolog device here in Melbourne. We chat first about Neurosafe and why intra-operative margin assessment is important, and then dive into Histolog which Greg has some experience with. Histolog uses confocal laser microscopy to assess the prostate specimen at the time of surgery, with a similar principle to frozen section analysis as used in the Neurosafe technique. However Histolog offers a lot more convenience and removes some of the practical barriers we face with frozen section, which are barriers to implementation. But is it as good as frozen section? Join your usual hosts Declan Murphy and Renu Eapen to find out more. Many thanks to our Silver Partners, Device Technologies, who are distributing the Histolog technology here in Australia, and to Samantree who are the manufacturers of the Histolog device. This episode better enjoyed on our YouTube channel (if you don't mind some surgical scenes)!LinksPrevious GU Cast on Neurosafe with Greg Shaw and colleagues Histolog device manufacturer websiteÂ
-------- Â
32:47
--------
32:47
Joe Biden, Koalas, Red wine and EMR Delinquency | With Ketan Badani
A wonderful meandering chat with Ketan Badani (Urologist, Mt Sinai, NYC)! We took him for a wine tour in the Yarra Valley, stopping for a pod chat at Rochford Winery about screening for prostate cancer in older men, plus a great tour around Healesviile Sanctuary to introduce Ketan to some Australian wildlife. Then back in Melbourne we had another chat, this time a bit of future-gazing about the future of surgery, and Declan and Ketan trade tales about EMR (that's Electronic Medical Record) delinquency. Ketan was visiting Melbourne as a guest of Device Technologies to speak at the Epworth Healthcare Robotic Urology Masterclass. And what a great guest he was! With your usual hosts Renu Eapen and Declan Murphy. Thanks to our fantastic guide Trish at Healesville Sanctuary, and Beatrice who looked after us at Rochford Winery.This one much better enjoyed on our YouTube channel!Links:Rochford Winery Healesville SanctuaryÂ
A urology podcast, focussing on prostate cancer, kidney cancer, bladder cancer, testis and penile cancer. Join Professor Declan Murphy and Dr Renu Eapen from Peter MacCallum Cancer Centre in Melbourne for this regular dive into the world of genitourinary (GU) Oncology and Urology. Regular guests from all over the world, from every walk of life. Find out more gucast.org
Ireland