What is Histolog?? Well, now that intra operative margin assessment is a such a hot topic in prostate cancer surgery after the Neurosafe RCT read-out, we thought we would dive into one of the other new technologies for doing something similar, but without the pragmatic challenges of frozen section. The idea is to assess the surgical margin of the prostate at the time of surgery to improve nerve sparing and sexual function for patients.We are joined by Professor Greg Shaw (University College London, UK), PI of the Neurosafe Proof trial, which we already featured following their Lancet Oncology paper in March 2025, and our colleague Professor Nathan Lawrentschuk (Peter MacCallum Cancer Centre, AUS), who is leading a study of the Histolog device here in Melbourne. We chat first about Neurosafe and why intra-operative margin assessment is important, and then dive into Histolog which Greg has some experience with. Histolog uses confocal laser microscopy to assess the prostate specimen at the time of surgery, with a similar principle to frozen section analysis as used in the Neurosafe technique. However Histolog offers a lot more convenience and removes some of the practical barriers we face with frozen section, which are barriers to implementation. But is it as good as frozen section? Join your usual hosts Declan Murphy and Renu Eapen to find out more. Many thanks to our Silver Partners, Device Technologies, who are distributing the Histolog technology here in Australia, and to Samantree who are the manufacturers of the Histolog device. This episode better enjoyed on our YouTube channel (if you don't mind some surgical scenes)!LinksPrevious GU Cast on Neurosafe with Greg Shaw and colleagues Histolog device manufacturer websiteÂ
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Joe Biden, Koalas, Red wine and EMR Delinquency | With Ketan Badani
A wonderful meandering chat with Ketan Badani (Urologist, Mt Sinai, NYC)! We took him for a wine tour in the Yarra Valley, stopping for a pod chat at Rochford Winery about screening for prostate cancer in older men, plus a great tour around Healesviile Sanctuary to introduce Ketan to some Australian wildlife. Then back in Melbourne we had another chat, this time a bit of future-gazing about the future of surgery, and Declan and Ketan trade tales about EMR (that's Electronic Medical Record) delinquency. Ketan was visiting Melbourne as a guest of Device Technologies to speak at the Epworth Healthcare Robotic Urology Masterclass. And what a great guest he was! With your usual hosts Renu Eapen and Declan Murphy. Thanks to our fantastic guide Trish at Healesville Sanctuary, and Beatrice who looked after us at Rochford Winery.This one much better enjoyed on our YouTube channel!Links:Rochford Winery Healesville SanctuaryÂ
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Advanced kidney cancer for Dummies! With Danny Heng & Lewis Au
A Masterclass in advanced kidney cancer today with the great Danny Heng (University of Calgary, Canada), and our own Lewis Au (Peter MacCallum Cancer Centre, Melbourne). Both popped into the GU Cast studio while Danny was in Australia doing some lectures and visiitng us at Peter Mac.We challenged Danny and Lewis to simplify three hot topics in kidney cancer, ideal if (like us) you find it difficult to keep up with this fast-moving area. The three areas are:1. What sort of patient is this? Risk stratification made easy (by Danny, Master of the universe of Risk Stratification in kidney cancer)2. Novel scans and biomarkers in kidney cancer - a bluffers guide 3. Neoadjuvant and adjuvant therapies in kidney cancer - what the urologist needs to know Even better on our YouTube channel
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En-COMPASSing collaborative research | With Veeru Kasi & team
Meet the young new faces of collaborative urological research!! GU Cast host Declan Murphy discusses the latest in international collaborative trials with A/Prof Veeru Kasivisvanathan, Dr Alexander Ng, and highly ambitious medical students, Miss Aishwarya Shah and Mr Alexander Dudko. They discuss their latest research from the COMPASS group including the PRIME trial (bpMRI vs mpMRI in detecting prostate cancer), and upcoming PARADIGM (AI vs Radiologists in detecting prostate cancer trials. And from BURST Urology we hear an update from the RESECT (can audit and feedback improve TURBT outcomes?) trial. The team discusses mentorship and bringing up the next generation of early career researchers, including medical students and early-stage trainees.Even better on our Youtube channelLinks:·     COMPASS ·     PRIME DOI·     PARADIGM DOI·     BURST ·     RESECT DOI
A urology podcast, focussing on prostate cancer, kidney cancer, bladder cancer, testis and penile cancer. Join Professor Declan Murphy and Dr Renu Eapen from Peter MacCallum Cancer Centre in Melbourne for this regular dive into the world of genitourinary (GU) Oncology and Urology. Regular guests from all over the world, from every walk of life. Find out more gucast.org