PodcastsHealth & WellnessPeptide of The Week

Peptide of The Week

JD Denham and Will Haas
Peptide of The Week
Latest episode

97 episodes

  • Peptide of The Week

    Peptide Q&A #42 – Starting in Peptides, Peptides for dogs, Skin Pigment Changes & Type 1 Diabetes

    21/05/2026 | 1h
    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

    Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover how to get started in the peptide space, skin pigment changes from GH peptides, peptide protocols for Type 1 diabetes, endometriosis, old chronic injuries, and yes peptides for your dog.

    Chapters:

    00:00 – Intro & Vegas Plans
    02:20 – How Business Success Really Happens
    06:24 – Discipline, Purpose & The Warrior Gene
    11:20 – Gratitude for the Audience
    12:57 – How to Start in Peptides
    19:08 – Best Resources to Learn Peptides
    22:32 – Why Peptides Are Exploding
    24:21 – IGF-1, Ipamorelin & Skin Pigmentation
    27:16 – Type 1 Diabetes & Peptide Recommendations
    31:43 – Fat Loss, Muscle Growth & GLP-1 Strategy
    36:48 – Cardiovascular Health & Statin Alternatives
    41:37 – Healing Chronic Injuries with Peptides
    47:47 – Mixing Peptides in One Syringe
    52:40 – Endometriosis, Autoimmune & Inflammation
    55:35 – Peptides for Dogs & Joint Health
    58:58 – Outro & Upcoming Episodes

    We cover:
    • How to Get Started in the Peptide Space: Why an RN license helps, why the research-only space has limits, and how white-labeling and deep studying are the real entry points
    • Best Resources for Learning Peptides: Why PubMed beats any book, how Jay Campbell's work holds up, and why self-experimentation is irreplaceable
    • Skin Pigment Changes on GH Peptides: Why higher GH levels can affect melanin, what Melanotan 2 symptoms look like, and why switching to real HGH may be the cleaner move
    • Peptides for Type 1 Diabetes: Why secretagogues and GLPs carry real risk, and which peptides like AOD, BPC, NAD and SS-31 are safer options
    • Dropping Tirzepatide for Retatrutide: How to taper down half a milligram at a time and why staying under four migs of Reta is the sweet spot
    • Statins vs. Peptides for ApoB: Why diet and fasting outperform any peptide here, and where Cardiogen, BPC and Reta offer cardiovascular support
    • Wolverine Stack for Old Chronic Injuries: Why TB-500 is the key compound for dormant injuries, how GHK-CU supports nerve healing, and why movement matters as much as the peptide
    • Mixing Peptides in One Syringe: What to never combine, why AOD needs its own water, and when HGH and GLPs should always stay separate
    • Endometriosis & Hashimoto's Protocol: Why KPV and TA-1 are right, the role of LL-37 at micro doses, and why VIP helps flush the Herxheimer reaction
    • Peptides for Your Dog's Bad Hips: Why BPC and TB-500 work on canines, how to dose by weight, and why injecting right at the hips is the best approach

    📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.

    You're a warrior. Act like one.

    Follow us on social media:
    JD's Instagram: https://www.instagram.com/jd_denham_fit
    Will's Instagram: https://www.instagram.com/williamthaas/
    Join The Community: https://www.skool.com/peptideresearchinstitute/about
  • Peptide of The Week

    Peptide of the Week: Autoimmune, Gut Health & GLP-1s – With Paul Bakhtiar

    18/05/2026 | 1h 7 mins.
    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

    Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas are joined by returning fan favorite Paul Bakhtiar peptide Jedi and clinical consultant for a deep dive into autoimmune disorders, gut health, GLP-1 optimization, and protocols working in real clinical settings.

    Chapters:
    00:00 – Intro & Mixing Peptides Debate
    04:44 – Peptides for Recovery & Inflammation
    09:31 – Autoimmune Disorders Explained
    15:30 – Thymalin, TA1 & Immune Function
    18:38 – LL-37, VIP & Pathogen Response
    23:13 – Crohn’s, Hashimoto’s & Gut Health
    27:06 – BPC-157, Angiogenesis & Healing
    32:19 – Surgery Recovery & Peptide Protocols
    33:01 – Vitiligo, Psoriasis & Skin Healing
    35:35 – Folliculitis, Leaky Gut & Carnivore
    41:10 – Toxins, Sauna & Detoxification
    46:04 – GLP-1s, Inflammation & Neuroprotection
    52:04 – Estrogen, TRT & Bloodwork Optimization
    56:44 – SS-31, MOTS-C & Neuropathy Recovery

    We cover:
    🧬 What's happening in autoimmune disorders
    – Body attacks itself — thyroid in Hashimoto's, gut in Crohn's, skin in psoriasis
    – 80% of diagnosed autoimmune disorders occur in women
    – Root cause is almost always the gut — fix the gut, everything follows
    – Antibiotics, processed food, seed oils, stress, and poor sleep are the biggest culprits

    🛡️ Master Autoimmune Protocol (Psoriasis, Lupus, Lyme, MS)
    – Thymalin: re-educates immune system — the marathon (5–10mg, 10 days straight)
    – Thymosin Alpha-1 (TA-1): quick sprint to boost T cells (1.5mg, 3x/week, 6–8 weeks)
    – Run both together
    – LL-37: penetrates biofilm, dumps pathogens — 125mcg for 50 days
    – ⚠️ Don't start LL-37 too early — triggers Herxheimer reaction
    – VIP: cleans up after LL-37 — start 100mcg 3x/week, build to 200mcg
    – Always anchor with KPV + BPC-157

    🦠 Crohn's & Colitis Protocol
    – KPV + BPC-157 orally first — straight to the source
    – Add Thymalin + TA-1 simultaneously
    – Bring in LL-37 if not responding, follow with VIP, then MoTC
    – Support stack: Glutathione + NAC + L-Glutamine

    🦋 Hashimoto's Protocol
    – Same immune foundation: TA-1, Thymalin, KPV, BPC-157 + MoTC
    – Once markers trend down — add GH peptides (Tesmorelin or CJC + Ipamorelin) for muscle wasting
    – Monitor insulin, thyroid levels, and autoimmune markers before adding GH axis

    🧫 SS-31 vs MoTC
    – SS-31 first: repairs the engine
    – MoTC second: press the gas
    – SS-31 also powerful for kidney repair, neuropathy, and heart health

    🔬 ARA-290
    – Derivative of EPO — no blood doping effects
    – Exceptional for neuropathy and nerve regeneration
    – Pairs well with SS-31

    💉 GLP-1 Optimization
    – Reta: Paul hasn't seen anyone need to exceed 8mg
    – Plateaued on tirzepatide or sema? Titrate down while titrating Reta up
    – Clinical tip: GLP-1 on Monday → add small CAG dose by Thursday to quiet food noise
    – GLP-1s are neuroprotective — control glucose to the brain, help prevent Type 3 Diabetes (Alzheimer's, Parkinson's, dementia)

    💡 Real Talk
    – No peptide protocol doesn't benefit from BPC-157
    – Sauna 3x/week at 150–160°F for 20 min is one of the best detox tools available
    – The compounds work. The lifestyle makes them extraordinary.

    🧪 This isn't theory this is real-world experience working with hundreds of people and seeing what actually works.

    📺 Subscribe for more no-fluff peptide education every week.

    Follow us on social media:
    JD's Instagram: https://www.instagram.com/jd_denham_fit
    Will's Instagram: https://www.instagram.com/williamthaas/
    Paul's Instagram: https://www.instagram.com/paulbakhtiar/

    Join The Community: https://www.skool.com/peptideresearchinstitute/about
  • Peptide of The Week

    Peptide Q&A #41 – Peptide Blends, Injury Protocols, Carrier Oils & Tesamorelin Storage

    14/05/2026 | 1h 22 mins.
    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

    Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover low testosterone at 32, post-surgery wound healing, switching GLPs, peptide blend dosing math, carrier oils for testosterone, and how to properly store Tesamorelin.

    Chapters:
    00:00 – Intro & Wedding Weekend Recap
    05:21 – Traveling, Kids & Family Life
    11:06 – TRT, RETA & Fat Loss Questions
    19:18 – Wolverine Stack & Healing Protocols
    23:57 – Weight Loss, HGH & Recovery
    31:01 – Arthritis, Injuries & Joint Healing
    38:20 – Women’s Fat Loss & Hormone Support
    45:50 – Mixing GLP-1s & RETA Questions
    49:26 – Fat Loss, Longevity & Busy Moms
    56:02 – Peptide Blend Dosing Explained
    01:01:04 – Testosterone Carrier Oils Explained

    We cover:
    • Low Testosterone at 32: Why 369 total T is a 60-year-old's number, what a full hormone panel should include, and why TRT isn't a life sentence
    • Post-Surgery Wound Healing: Why BPC, TB-500 and KPV at high doses beats the Wolverine blend for open incisions and when to add the serum
    • Back Injury Dosing: When to run a loading phase vs. maintenance, why resting matters as much as the peptide, and how to identify structural vs. tissue injuries
    • Retired NYPD with Arthritis & Tendonitis: Why aggressive Wolverine dosing, Thymosin Alpha-1, and HGH are the right protocol for chronic job-related injuries
    • Can You Stack Two GLP-1s?: Why you don't need to and why Retatrutide does everything Tirzepatide does but better
    • Fat Loss Stack for Active Mom: Why Tesamorelin, NAD, GHK-CU, SLU-PP-332 and creatine covers all goals with minimal injections
    • 37-Year-Old Female Physique Goals: Why PT-141, Tesamorelin/Ipa blend, NAD, Tesofensine and C-Max/C-Long hit every target from fat loss to sex drive
    • Peptide Blend Dosing Math Explained: How to calculate exact milligrams per unit for any blend using simple division — no guesswork
    • Carrier Oils for Testosterone: MCT vs. grape seed vs. cottonseed vs. castor oil, what Miglyol 840 actually is, and why concentration matters more than the oil itself
    • Tesamorelin Storage After Mixing: Why room temp water and a cool dark place beats the fridge, and how to buy the right vial size so nothing goes to waste

    📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.

    You're a warrior. Act like one.

    Follow us on social media:
    JD's Instagram: https://www.instagram.com/jd_denham_fit
    Will's Instagram: https://www.instagram.com/williamthaas/
    Join The Community: https://www.skool.com/peptideresearchinstitute/about
  • Peptide of The Week

    Peptide of the Week: KPV & PT-141 – Gut Health, Inflammation & Libido

    11/05/2026 | 38 mins.
    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

    Welcome back, warriors! In this episode of Peptide of the Week, JD Denham and William T. Haas break down two peptides that are more connected than you'd think KPV for inflammation and gut health, and PT-141 for libido and arousal. One calms the fire inside, the other lights a different kind of fire.

    Chapters:
    00:00 Intro
    00:09 Welcome & Banter (Myrtle Beach, Sharks)
    03:23 Today's Topics Overview
    05:55 KPV: What It Is & How It Works
    08:06 KPV vs NSAIDs – Targeted Inflammation
    09:00 KPV for Gut Health & Stacking with BPC
    15:00 Stress, Cortisol & Body Composition
    20:25 Peptides vs Western Medicine
    21:26 KPV Real Life Results
    25:43 PT-141: Introduction
    26:14 How PT-141 Was Discovered
    27:21 PT-141 vs Viagra/Cialis
    36:22 PT-141 Dosing Tips & Final Thoughts
    37:49 Outro

    We cover:
    🧬 What is KPV?
    – A tri-peptide (just 3 amino acids) derived from alpha-MSH — the same hormone PT-141 comes from
    – Your body naturally produces it — virtually zero side effect profile
    – Selectively targets inflammation rather than shutting it all off like NSAIDs
    – Calms cytokine storms and autoimmune responses without killing good inflammation
    – Works in tandem with BPC-157 — KPV calms the environment, BPC does the tissue repair

    🔥 What KPV actually treats
    – Crohn's disease, ulcerative colitis, microscopic colitis, IBS, leaky gut
    – Inflammatory skin conditions — eczema, psoriasis, rosacea, chronic acne
    – Post-antibiotic gut damage — if you ran antibiotics, run KPV
    – Athletes overtraining — reduces chronic inflammation that slows recovery past 48 hours
    – Any autoimmune condition driven by gut dysfunction

    ⚠️ The cortisol connection
    – Stress, poor sleep, alcohol, and travel all spike cortisol — your body's fight-or-flight hormone
    – Cortisol breaks muscle down, converts it to sugar, and stores fat right at the belly button
    – Less than 5 hours of sleep = no fat burning, no muscle building all day long
    – Alcohol keeps your body out of fat-burning mode until 2–3 PM the next day
    – KPV helps combat the inflammatory cascade that chronic cortisol creates

    🔥 What is PT-141?
    – Also derived from alpha-MSH — same origin as KPV, completely different job
    – Discovered accidentally in the 1980s at University of Arizona during tanning research — men started getting spontaneous erections
    – FDA approved in 2019 for hypoactive sexual desire disorder in post-menopausal women
    – Works on the BRAIN — not blood vessels like Viagra or Cialis
    – Boosts dopamine = increases desire, motivation, and arousal from the inside out
    – Works equally well for men AND women

    💡 How it feels (real-world experience)
    – Kicks in 45 minutes after injection
    – Flushing/redness right after injection is normal
    – Arousal builds gradually — touch or kissing accelerates the effect significantly
    – Hypersensitivity during the act
    – Too much = nausea, elevated blood pressure, feeling "off" — find your dose
    – JD's experience at 2mg: incredible night, felt like a 16-year-old all the next day — too much

    ⚠️ What to watch with PT-141
    – Can raise blood pressure at higher doses — monitor if sensitive
    – Nausea is common, especially early on — usually a quick wave that passes
    – Do NOT take with uncontrolled hypertension
    – Don't combine with other vasodilators carelessly

    🧪 This isn't theory this is real-world experience working with hundreds of people and seeing what actually works.

    📺 Subscribe for more no-fluff peptide education every week.

    Follow us on social media:
    JD's Instagram: https://www.instagram.com/jd_denham_fit
    Will's Instagram: https://www.instagram.com/williamthaas/

    Join The Community: https://www.skool.com/peptideresearchinstitute/about
  • Peptide of The Week

    Peptide Q&A #40 - Traveling With Peptides, Tirzepatide vs. Retatrutide & Bacteriostatic Water Facts

    07/05/2026 | 1h 4 mins.
    Medical Disclaimer: We are not doctors. The content in this video is for educational and informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease. Any compounds discussed may be intended for research purposes only. Use at your own risk.

    Welcome back, warriors! In this week's Peptide Q&A, JD Denham and William T. Haas cover bacteriostatic water shelf life, traveling with peptides, fixing chronic injuries, why Clenbuterol is outdated, and when to switch from Tirzepatide to Retatrutide.

    Chapters:
    00:00 – Intro & Parenting Talk
    07:59 – Warrior Makers Meetup & School Update
    10:06 – Bacteriostatic Water & AOD Discussion
    15:28 – PNC-27, Cancer & Fasting
    21:06 – Back Injury, Wolverine & Healing
    26:10 – Loose Skin, GHK-CU & Fat Loss
    30:43 – Traveling with Peptides & Retatrutide
    38:26 – Sleep, Brain Fog & Recovery
    43:26 – TRT, HGH & Fat Loss Stack
    47:48 – Anavar, Clenbuterol & Cutting
    52:15 – HGH, Tesa & Long-Term Protocols
    56:32 – Tendonitis, Recovery & Wolverine Dosing
    1:00:47 – Weight Loss Plateau & Retatrutide

    We cover:
    • Bacteriostatic Water — The Real 28-Day Rule: What actually happens after 28 days and why bottle size affects your timeline
    • AOD-9604 After 13 Weeks: Why it's time to rotate and what SLU-PP-332 and 5-Amino-1-MQ can replace it with
    • PNC-27 for Cancer Prevention: What the science says and why fasting may still be the smarter proactive move
    • Back Injury at Night, Fine During Day: When BPC + TB-500 help vs. when it's a structural issue requiring higher doses
    • Loose Skin After Major Fat Loss: Why GHK-CU beats Snap-8 for collagen remodeling and why HGH is the real game changer
    • Traveling With Peptides: Check your bag, use a peptide case, travel unmixed, and why syringes cause more headaches than peptides
    • Switching From Tirzepatide to Retatrutide: Why poor appetite is a side effect not a goal and why you don't need to wait 14 days
    • Sleep Protocol That Actually Worked: Magnesium glycinate, glycine, ashwagandha, time-release melatonin and Epithalon for circadian reset
    • Anavar vs. Clenbuterol: Why Clen is largely outdated and why high-dose SLU-PP-332 or Retatrutide does it cleaner
    • HGH Plus Tesamorelin — Does It Make Sense?: Why Tessa still burns belly fat even when HGH suppresses pituitary signaling
    • Chronic Heel Tendonitis Protocol: Why two years of injury needs a heavy loading blast and why rest matters just as much

    📌 Subscribe for weekly, no-fluff protocols, dosing guidance, and real-world results.

    You're a warrior. Act like one.

    Follow us on social media:
    JD's Instagram: https://www.instagram.com/jd_denham_fit
    Will's Instagram: https://www.instagram.com/williamthaas/
    Join The Community: https://www.skool.com/peptideresearchinstitute/about
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About Peptide of The Week
Hosted by JD Denham and Will Haas, The Peptide of The Week Podcastis your no-BS guide to peptides, performance, and total body optimization. Whether you’re an athlete, a high performer, or just hungry to feel better, move better, and live stronger this show’s for you. JD and Will dive deep into real-world protocols, hard-earned lessons, and the science behind what actually works. With expert guests and raw conversations, you’ll get everything from cutting-edge peptide talk to diet, training, recovery, and mindset. No fluff. No filters. Just the tools to rebuild your body and upgrade your life.
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