The Neuro Experience

• Methylene Blue & Mitochondria: How This Compound Fights Alzheimer's and Brain Aging

  I'm excited to share my conversation with Dr. Scott Sherr, where we dive deep into methylene blue - a compound you've probably seen all over social media lately (those blue tongues!). As someone whose primary research focuses on Alzheimer's disease, I was fascinated to explore the science behind this molecule that dates back to the 1870s and was actually the first drug registered with the FDA in 1897.  The most fascinating insight for me was learning how methylene blue can serve as an electron acceptor in our mitochondria - essentially functioning as a substitute for oxygen when our cells are under stress. This explains why it shows promise for everything from traumatic brain injury to cognitive enhancement and even as a potential alternative to stimulant medications.   If you're interested in optimizing brain performance, understanding mitochondrial health, or simply curious about this blue compound that's suddenly everywhere, this episode provides both the scientific foundation and practical applications you need. Subscribe to The Neuroscience Experience for more conversations at the intersection of brain science and performance. I'm committed to bringing you evidence-based insights that you can apply to your own health journey.  SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:Hone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuroTroscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.- Get 10% off: https://troscriptions.com/NEURO- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMailTimestamps 00:00 Introduction 02:30 Methylene Blue's Role in Neurotransmitter Regulation 07:54 Mitochondrial Health and Methylene Blue 17:02 Methylene Blue and Modern Health Challenges 25:27 Methylene Blue in Hypobaric and Hyperbaric Environments 29:47 Understanding Hyperbaric Oxygen Therapy 32:27 Methylene Blue: A Mitochondrial Rescue 36:52 Bioavailability of Methylene Blue 42:17 Dosing and Applications of Methylene Blue 47:46 Combining Methylene Blue with Other Treatments 54:02 Conclusion and Further ResourcesThe Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

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• What Are the 3 Key Blood Tests for Alzheimer's Detection? | A Woman’s Guide to Alzheimer’s Disease | Part 2

  Alzheimer’s doesn’t just “happen” later in life—it’s a slow, silent process that can begin decades before symptoms appear. In this solo episode, we challenge the myth that Alzheimer’s is purely genetic, and break down what the science really says about your risk. I explore the role of the APOE4 gene, how it interacts with lifestyle and metabolic health, and why women—especially during and after menopause—may face a unique vulnerability. Most importantly, I introduce three cutting-edge blood tests that can detect the earliest signs of Alzheimer’s, long before memory loss sets in. We’ll also talk prevention: from blood sugar and insulin resistance to inflammation, hormone balance, and brain energy metabolism—everything you can start doing right now to safeguard your cognitive future. This is more than a conversation about Alzheimer’s—it’s a roadmap for taking control of your brain health. SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:ZocDoc – Finding a great doctor has never been easier. With ZocDoc, you can browse top-rated physicians, read real patient reviews, and book appointments online - all in one place. Get started here: https://www.zocdoc.com/neuroHone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuroTroscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.- Get 10% off: https://troscriptions.com/NEURO- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMailTimestamps: 00:00 Top Alzheimer’s Myth: Genetics Don’t Seal Your Fate01:43 APOE4 Gene Explained: Risk Factors vs. Reality 04:00 Alzheimer’s Risk Isn’t Just in Your DNA10:50 Top 3 Alzheimer’s Biomarkers You Can Test for Today14:47 APOE4 Prevention Plan: Lifestyle Changes That Protect Your Brain The Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

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• Dr. Rena Malik: The Science of Testosterone & Its Impact on Mood, Cognition & Longevity in Women

  Testosterone is often misunderstood as a male-exclusive hormone, but did you know that women have four times more testosterone than estrogen? In this episode, I sit down with leading urologist and sexual health expert Dr Rena Malik to uncover the critical role testosterone plays in cognitive function, energy levels, muscle strength, and overall well-being in women.We explore:• The misunderstood role of testosterone in female physiology• Why testosterone deficiency is more common than you think – and how to identify it• The impact of stress, sleep, and modern lifestyles on hormonal balance• The link between testosterone and brain fog, motivation, and libido• Why resistance training is essential for hormonal health• Medical vs. natural interventions – from supplementation to lifestyle strategiesWith emerging research highlighting the intricate relationship between hormones and long-term cognitive and metabolic health, this conversation is a must-listen for anyone looking to optimise longevity, vitality, and performance.SponsorsA huge thank you to my sponsors for supporting this episode. Check them out and enjoy exclusive discounts:ZocDoc – Finding a great doctor has never been easier. With ZocDoc, you can browse top-rated physicians, read real patient reviews, and book appointments online - all in one place. Get started here: https://www.zocdoc.com/neuroHone Health – Take control of your hormones with at-home testing designed specifically for men. Get personalized insights and expert guidance to optimize your health and performance. Learn more at: https://honehealth.com/Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you’re looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuroTroscriptions – Unlock your cognitive potential with precision-dosed nootropics developed by medical experts. Whether you need more focus, clarity, or energy, Troscriptions offers innovative solutions.- Get 10% off: https://troscriptions.com/NEURO- https://troscriptions.com/discount/NEUROMAIL?utm_source=affiliate&utm_medium=email&utm_campaign=NeuroMailTimestamps:00:00 Introduction01:58 Symptoms and Effects of Low Testosterone03:06 Testosterone's Role in Female Health06:58 Factors Affecting Testosterone Levels10:57 Impact of Lifestyle on Hormone Levels15:00 Seasonal and Circadian Influences20:41 Perimenopause and Hormonal Changes24:18 The Role of Testosterone in Mood and Motivation31:53 DHEA Supplementation and Hormonal Balance40:01 The Importance of Strength Training and Sleep44:31 Nutritional Tips for Hormonal HealthThe Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

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• A Woman's Guide to Alzheimer's Disease: Part 1 with Louisa Nicola

  In today's episode I am kicking off a 10-part series, "Women's Guide to Alzheimer's Disease," focusing on understanding the complexities of the brain. Delve into the basics of neurons, synaptic connections, and the essential role of vascular health in cognitive function. Discover how lifestyle factors contribute to Alzheimer's and the critical window for intervention. Explore key elements like mitochondrial function and the APOE4 gene's impact. With insights into brain health and disease prevention, this episode lays the groundwork for optimizing cognitive performance and demystifying Alzheimer's.SponsorsZocDoc: https://www.zocdoc.com/neuroMomentous - Use code NEURO to get 20% off your order - https://www.livemomentous.com/neuroTimestamps 0:00 Understanding the Brain's Role in Alzheimer's Disease3:55 Momentous Supplements: Purity, Potency, and Safety Guaranteed5:15 Streamlining Doctor Appointments with Zocdoc6:38 The Brain's Vascular Health and Its Link to Alzheimer's9:27 Understanding Alzheimer's Disease and Brain Health InterventionsThe Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

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• Zone 2 Training and Cancer Metabolism: The Science Behind Peak Metabolic Health | Dr Inigo San Millan

  Dr. Inigo San Milan: Leading Expert in Metabolism, Exercise Physiology, and Cancer ResearchDr. Inigo San Milan is a globally recognized expert in metabolic health, exercise science, Zone 2 training, mitochondrial function, and cancer metabolism.His groundbreaking research has transformed the understanding of lactate, highlighting its role not just in athletic performance but also in metabolic diseases, cancer progression, and longevity. As a strong advocate of Zone 2 training, Dr. San Milan has demonstrated how it boosts mitochondrial efficiency, improves endurance, enhances fat metabolism, and supports overall healthspan.His pioneering approach explores cancer treatment through metabolic optimization, shifting the focus from traditional gene-targeted therapies to cellular energy balance and metabolic interventions. Dr. San Milan’s work provides a science-backed strategy for disease prevention, peak performance, and longevity through targeted metabolic conditioning.Sponsors:ZocDoc: https://www.zocdoc.com/neuroHone Health Hormone Testing: https://honehealth.com/Momentous - Use code NEURO to get 20% off your order - https://www.livemomentous.com/neuroTimestamps0:00 Revolutionizing Cancer Treatment Through Metabolism Optimization5:00 Exploring Skeletal Muscle's Role in Cancer Prevention and Treatment13:14 Lactate's Role in Cancer and Metabolic Disorders18:21 Nanoparticles in Cancer Treatment and Funding Challenges22:21 Understanding Zone 2 Training and Its Potential Health Benefits25:52 Understanding Exercise Zones and Metabolic Fuel Sources31:39 The Benefits of Zone Two Training for Longevity and Health40:50 Rethinking Exercise Guidelines for Optimal Health43:11 Exploring the Impact of Zone 2 Exercise on Cancer50:41 Optimizing Exercise for Cancer Prevention and LongevityThe Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

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