June 2025: Stratifying Risk for Postpartum Depression at Time of Hospital Discharge
Dr. Roy Perlis (Mass General Bringham, Boston) joins AJP Audio to discuss a machine learning model to examine electronic health records in individuals who had recently given birth designed to detect those who might develop postpartum depression. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the June issue into context. 00:31 Perlis interview 02:56 Lack of validation in screening methods 04:03 Stumbling blocks on the road to validation 05:10 Synergy between screening scores and machine learning models 06:36 Issues with clinician adoption? 08:44 Administrative burden for running these models 10:38 Current clinical application 12:37 Screening without those with a history of depression 13:48 Limitations 15:30 Future research 17:26 Kalin interview 17:41 Clapp et al. 21:41 Kępińska et al. 25:19 Savitz et al. 25:25 Miller 28:38 Wall et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
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32:41
May 2025: Randomized Controlled Trial of “Bounce Back Now,” a Mobile App to Reduce Post-Disaster Symptoms of Posttraumatic Stress, Depressed Mood, and Sleep Disturbance
Dr. Kenneth Ruggiero (Medical University of South Carolina, Charleston) joins AJP Audio to discuss the the effectiveness of an app-based intervention at reducing the symptoms of sleeplessness and posttraumatic stress in a broad cohort in the wake of a natural disaster. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the May issue into context. 00:38 Ruggiero interview 03:13 Bounce Back Now app 05:03 Natural disasters and other sources of trauma 07:31 Low cost and broad-based intervention 08:49 Limitations 10:19 Changes in how the intervention was designed 11:17 Uptake and interactions with the app 13:15 Future directions 14:36 Kalin interview 14:50 Ruggiero et al. 19:26 Norman et al. 23:29 Conrod et al. 27:53 Olfson et al. 31:44 Olfson et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
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April 2025: Anticholinergic Burden and Cognitive Function in Psychosis: A Systematic Review and Meta-Analysis
Dr. Valentina Mancini (Oxford University) joins AJP Audio to discuss the impact of anticholinergic burden on cognition in patients with schizophrenia. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context. 00:32 Mancini interview 02:26 Anticholinergic burden method of action 02:58 Balancing the impact of side effects in schizophrenia treatment 04:52 Limitations 05:34 The need for further studies 05:59 Clinical implications 06:32 Further research 07:01 Trials needed 07:54 Kalin interview 08:03 Mancini et al. 11:23 Tiihonen et al. 13:43 Zhou et al. 16:28 Omlor et al. 18:51 Orhan et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
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March 2025: The Impact of Xanomeline and Trospium Chloride on Cognitive Impairment in Acute Schizophrenia: Replication in Pooled Data From Two Phase 3 Trials
Dr. William Horan (Bristol Myers Squibb) joins AJP Audio to discuss a newly approved, novel treatment for schizophrenia spectrum disorder, which has potential impacts for cognition in patients. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin puts the rest of the March issue into context. 00:45 Horan interview 03:15 Novel mechanism of action in the treatment of schizophrenia 05:39 Side effect profiles 07:20 Clinical impacts 08:31 The need for further investigation 09:58 Limitations 11:05 Further research 13:08 Kalin interview 13:21 Horan et al. 17:34 Levenstein et al. 19:00 Fountoulakis et al. 20:57 Couture et al. 23:18 Stern et al. 27:35 McGirr et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
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32:05
February 2025: Real-Time Assessment of Alcohol Reward, Stimulation, and Negative Affect in Individuals With and Without Alcohol Use Disorder and Depressive Disorders
Dr. Andrea King (University of Chicago Medicine) joins AJP Audio to discuss a novel, real time assessment of the reward, stimulation, and negative affect of alcohol use in people with alcohol use disorder with and without depressive disorders. Afterwards, AJP Editor-in-Chief Dr. Ned Kalin discusses the rest of the February issue, which focuses closely on issues surrounding addiction. 00:35 King interview 00:45 Allostatic model of addiction 02:12 Gathering data and the groups studied 07:37 The ethics of studying alcohol use in patients with AUD 10:38 Findings 13:29 The impacts of alcohol’s pleasurable effects on people with AUD and those without 14:32 Limitations of natural environment research versus laboratory research 18:18 Clinical implications 20:09 Further research 22:56 Kalin interview 23:03 King et al. 26:21 Brand et al. 28:12 Conway et al. 32:17 Kypriotakis et al. 35:42 Kuhn et al. 39:37 Grilo et al. Transcript Be sure to let your colleagues know about the podcast, and please rate and review it on Apple Podcasts, Google Podcasts, Spotify, or wherever you listen to it. Subscribe to the podcast here. Listen to other podcasts produced by the American Psychiatric Association. Browse articles online. How authors may submit their work. Follow the journals of APA Publishing on Twitter. E-mail us at ajp@psych.org
Each episode of AJP Audio brings you an in-depth look at one of the articles featured in that month’s issue of The American Journal of Psychiatry, the official journal of the American Psychiatric Association. Wide-ranging interviews with article authors cover the background, rationale, main findings, and future implications of the research.
This podcast is subject to the Terms of Use at ww.psychiatry.org. The views and opinions expressed in this podcast are those of the individual speakers only and do not necessarily represent the views of the American Psychiatric Association, its officers, trustees, or members. The content of this podcast is provided for general informational purposes only and is not intended as, and shall not be understood or construed as, medical or any other type of professional advice nor does it represent any statement of the standard of care. We strongly recommend that any listener follow the advice of physicians directly involved in their care and contact their local emergency response number for any medical emergency. The information within this podcast is provided as-is and is not guaranteed to be correct, complete, or accurate.
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