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Nearly a decade after the last major cholesterol guidelines were released, the new 2026 Multi-Specialty Lipid Guidelines introduce significant changes in how cardiovascular risk is assessed and managed. In this episode, Albert Lopez, DO, FACP, FASPC, explains why LDL cholesterol treatment goals have returned, how newer markers such as ApoB and Lipoprotein(a) are reshaping risk assessment, and why earlier, more aggressive treatment may help reduce the world's leading cause of death, cardiovascular disease.
Dr. Al Lopez, DO,  discusses the role of statins, non-HDL cholesterol, triglycerides, genetic cholesterol disorders, screening recommendations for children and older adults, and the importance of a team-based approach to prevention. Whether you're a healthcare professional or someone interested in protecting your heart health, this episode provides a practical overview of the latest evidence-based recommendations for preventing heart disease.
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Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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In this episode of MedEvidence, host Dr. Michael Koren speaks with epidemiologist Dr. Hannah Gardener about how everyday exposures may influence long-term health outcomes.
Dr. Gardener shares her journey from neuroscience and epidemiology training at Harvard to her current work studying stroke, dementia, and environmental risk factors. She explains how personal life experiences sparked her interest in environmental health and led her to examine how early-life and daily exposures can shape disease risk across the lifespan.
The conversation explores her research on diet soda consumption and its surprising associations with vascular outcomes, including stroke, heart disease, and cognitive decline. She breaks down what “prospective cohort studies” really mean and how to interpret findings without overgeneralizing results.
The discussion then expands to PFAS, often called “forever chemicals”, which are widely used in consumer products and persist in the environment and human body. Dr. Gardener explains where these chemicals are found, what health effects have been observed in the research, and practical, evidence-based strategies individuals can use to reduce exposure.
This episode offers a thoughtful, research-driven look at how environmental factors, diet choices, and chemical exposures intersect with long-term brain and cardiovascular health—and what can realistically be done today to reduce risk.
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Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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What do island-hopping physicians, aviation safety, sleep medicine, and nasal polyps have in common? Dr. Adam Shapiro.
In this episode of the MedEvidence Podcast, Dr. Michael Koren sits down with ENT specialist and sleep medicine expert Dr. Adam Shapiro to discuss his remarkable career practicing medicine in the U.S. Virgin Islands, commuting between islands as a pilot, and helping aviation professionals manage fatigue-related health issues.
The conversation then shifts to a practical masterclass on nasal polyps and sinus health. Dr. Shapiro explains what nasal polyps are, why they develop, how they affect breathing and sleep, and the latest minimally invasive treatment options available today. He also discusses the connection between nasal health, sleep apnea, chronic sinus problems, ear pressure issues, and overall quality of life.
Whether you're struggling with chronic congestion, sleep problems, recurrent sinus infections, or simply curious about the latest advances in ENT care, this episode offers expert insights and evidence-based guidance.
If you found this helpful, subscribe to MedEvidence and share the episode with someone who’s always congested.
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Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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What happens when a Harvard-trained psychiatrist follows the evidence beyond traditional medicine?
In this episode of MedEvidence, Dr. Michael Koren sits down with Dr. Carol Locke, physician entrepreneur and Chief Science Officer of OmegaBrite, to explore her remarkable journey from psychiatry and academic research at Harvard’s McLean Hospital to pioneering evidence-based omega-3 innovation.
Dr. Locke shares how clinical research into mood disorders led to surprising discoveries about omega-3 fatty acids, brain health, inflammation, stress response, and emotional resilience. Together, they break down the science behind omega-3 balance, the role of EPA and DHA, third-party testing, and what clinical trials reveal about omega-3 supplementation’s impact on mood, anxiety, inflammation, and overall wellness.
You’ll also hear insights on physician entrepreneurship, innovation in nutraceutical science, and why evidence-based quality matters when choosing supplements.
In this episode:
 How omega-3s influence brain function and mood 
 The link between inflammation, stress, and mental health 
 What clinical trials reveal about omega-3 supplementation 
 Why supplement purity and testing matter 
 Emerging science on omega-3 delivery to the brain 
 Advice for physicians pursuing innovation 
Be a part of advancing science by participating in clinical research.

Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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When T.J. Sharpe was diagnosed with stage 4 melanoma at just 37 years old, the statistics were devastating. With a newborn son, a two-year-old daughter, and limited treatment options available at the time, he faced a life-changing decision: pursue standard chemotherapy or take a chance on early immunotherapy clinical trials.
In this powerful episode of the MedEvidence Podcast, cardiologist and medical researcher Michael Koren sits down with T.J. to discuss his remarkable journey from cancer recurrence and uncertainty to becoming a long-term survivor through groundbreaking clinical research.
Be a part of advancing science by participating in clinical research.

Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com

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