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Cardiologists Dr. Seth Baum and Dr. Michael Koren discuss the newly released top-line results from a big Lp(a) study investigating the effects of the drug pelacarsen. They talk about what Lp(a) is, why it matters, happened in the study, and what this means for other pelacarsen and Lp(a) studies worldwide. They take a deep dive into some of the factors that can reduce the effectiveness of clinical trials and explain that this particular failure doesn't undermine the theory behind controlling Lp(a) levels or the potential effectiveness of competing investigational medications. Finally, the companion cardiologists talk about what this means for people who have high Lp(a) and what they can do to help control their risks of associated heart problems.
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Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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Dr. Mitchell Rothstein explains that GLPs have been with us for thousands of years. He gives a brief overview of how these medications work, some of the side effects they can cause, and to mitigate things like muscle loss and GI issues through exercise and dose management.
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Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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Dr. Mitchell Rothstein joins Dr. Michael Koren to discuss a current trend in unapproved medicine: peptides. They investigate what peptides are, why they have become so popular, and the very real problems with getting off-market medicines through the "grey market." They also talk about the history of peptides, including why they were banned from compounding pharmacies and why they are back on the market. Tune in for history, medicine, technical detail, and politics.
Be a part of advancing science by participating in clinical research.

Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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Music: Storyblocks - Corporate Inspired

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Dr. Steve Dorman joins Dr. Michael Koren to talk about vaccines, vaccine hesitancy, and the impact of politics on one of our most effective tools against disease. The doctoral duo, recorded in front of a live audience, talk about the big impacts of vaccines, including wiping out entire diseases like smallpox. They continue by cataloging success stories of vaccines, vaccine efficacy, and the emerging role of politics in vaccine adoption. They discuss the current administration's role in affecting vaccine science and adoption and weigh the importance of individual circumstance against herd immunity and population-wide effects.
Be a part of advancing science by participating in clinical research.

Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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Music: Storyblocks - Corporate Inspired

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Dr. John Shufeldt joins Dr. Mitchell Rothstein to discuss his life and the need for change in the US healthcare system. Dr. Shufeldt talks about the changes he has made in the healthcare space, from starting urgent care clinics in the 1990s to his healthcare venture capitol to his focus on indigenous populations and training the new generation of doctors. The two discuss the need for doctors to have a more flexible mind frame, the burgeoning role of AI in healthcare, and a focus on treating to biomarkers instead of treating to symptoms. Join the fascinating conversation with this healthcare disruptor.
Be a part of advancing science by participating in clinical research.

Have a question for Dr. Koren? Email him at askDrKoren@MedEvidence.com

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Want to learn more? Checkout our entire library of podcasts, videos, articles and presentations at www.MedEvidence.com

Music: Storyblocks - Corporate Inspired

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