The Dr. Josh Axe Show

What if aging isn’t simply your body “wearing out”… but your body losing the ability to repair itself? In this episode, Dr. Andrew Salzman joins Dr. Josh Axe to explain why chronic inflammation, leaky gut, and depleted NAD may quietly drain the very energy your cells need to heal, think, move, and survive.

 

Uncover what’s really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! →  http://mybloodwork.com

 

Thank you to our sponsors!

Sunlighten Sauna: https://get.sunlighten.com/axepodcast

Manukora Manuka Honey: https://manukora.com/axe

Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount

 

Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

 

🎧 Early Access!

Our listeners enjoy every episode before anyone else! Tune in below and join our exclusive group of listeners →

Spotify: https://bit.ly/DrJoshAxeSpotify

Apple Podcast: https://apple.co/3JDvWcS

 

Pre-order my NEW BOOK, Heal Your Cells → https://bit.ly/3QJBcQ5

 

Watch my free training on how to naturally balance your blood sugar and reverse your symptoms → http://DrAxeDiabetesClass.com

 

Discover practical steps you can take today to start healing your thyroid naturally →   http://DrAxeThyroidClass.com

 

If you’re ready to start feeling like yourself again and balance your hormones, take my free class → http://DrAxeHormoneClass.com

 

CONNECT WITH DR. JOSH AXE

Instagram → https://www.instagram.com/drjoshaxe/

Facebook → https://www.facebook.com/DrJoshAxe/

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X → https://x.com/drjoshaxe/

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Website →  http://thehealthinstitute.com

Sign up for my newsletter → https://bit.ly/4oE9Jf3

Ask Dr. Axe → http://speakpipe.com/drjoshaxe 

 

00:00 — Why Aging Is A Defect In Repair, Not Wear And Tear

01:42 — Meet Dr. Andrew Salzman: Harvard ICU Doctor & NAD Pioneer

03:07 — The 1991 Discovery That Changed Leaky Gut Research

06:59 — Why Doctors Dismissed Leaky Gut For Years

09:46 — DNA Damage, PARP Activation & The NAD Collapse

12:41 — How PARP Inhibitors Stopped Leaky Gut In The Lab

14:35 — What NAD Actually Does Inside Your Cells

21:31 — Best Food Sources For NAD & Creatine Support

24:55 — How Chronic Inflammation Activates PARP

25:56 — CD38: The Enzyme Draining Your NAD With Age

27:10 — NR vs NMN vs Niacin: Which NAD Supplement Makes Sense?

30:02 — Why NAD Is The “Centerpiece Of Biology”

34:24 — The Mouse Study Linking CD38, NAD & Ovarian Aging

35:30 — Why The Brain Is So Vulnerable To Low Cellular Energy

36:57 — Mitochondria As Power Stations: Why ATP Still Needs Delivery

39:31 — Butyrate, Brown Rice & Foods That Help Seal The Gut

41:59 — Flagella, LPS & The Hidden Drivers Of Gut Inflammation

43:36 — Dr. Salzman’s Top Longevity Priorities

45:45 — The New Definition Of Aging: Failed Repair

48:55 — Why Older Bodies Can Be “Operating On Fumes”

51:16 — NAD, Oxygen & Tissue Repair After Major Injury

55:35 — Creatine Dosage, Daily Loss & Why Supplementing May Matter

57:54 — Where To Find Dr. Salzman’s Research

59:01 — Final Thoughts: NAD, Creatine & Cellular Longevity

 

DISCLAIMER

This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

 

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What if you could naturally make your own version of Ozempic every time you eat the right meal? In this episode, Dr. Josh Axe breaks down the exact foods, supplements, probiotics, and meal timing strategies that help your gut activate GLP-1, the hormone that tells your brain you’re full, steadies blood sugar, and shuts down cravings.

 

Millions of people are spending hundreds or even thousands of dollars a month on GLP-1 drugs, but Dr. Axe says the real “Nature’s Ozempic” starts in your grocery store — with protein, fiber, polyphenols, fermented foods, and berberine.

 

Uncover what’s really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! →  http://mybloodwork.com

 

Download the FREE Nature’s Ozempic Guide: https://bit.ly/draxenaturesozempic

 

Thank you to our sponsors!

Sunlighten Sauna: https://get.sunlighten.com/axepodcast

Manukora Manuka Honey: https://manukora.com/axe

Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount

 

Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

 

🎧 Early Access!

Our listeners enjoy every episode before anyone else! Tune in below and join our exclusive group of listeners →

Spotify: https://bit.ly/DrJoshAxeSpotify

Apple Podcast: https://apple.co/3JDvWcS

 

Pre-order my NEW BOOK, Heal Your Cells → https://bit.ly/3QJBcQ5

 

Watch my free training on how to naturally balance your blood sugar and reverse your symptoms → http://DrAxeDiabetesClass.com

 

Discover practical steps you can take today to start healing your thyroid naturally →   http://DrAxeThyroidClass.com

 

If you’re ready to start feeling like yourself again and balance your hormones, take my free class → http://DrAxeHormoneClass.com

 

CONNECT WITH DR. JOSH AXE

Instagram → https://www.instagram.com/drjoshaxe/

Facebook → https://www.facebook.com/DrJoshAxe/

TikTok → https://www.tiktok.com/@thedrjoshaxeshow/

X → https://x.com/drjoshaxe/

LinkedIn → https://www.linkedin.com/in/joshaxe

Website →  http://thehealthinstitute.com

Sign up for my newsletter → https://bit.ly/4oE9Jf3

Ask Dr. Axe → http://speakpipe.com/drjoshaxe 

 

00:00 — The Hormone That Could Change Weight Loss

01:52 — What GLP-1 Actually Does In Your Body

04:45 — How GLP-1 Controls Hunger, Blood Sugar & Cravings

06:28 — The Stanford Discovery That Mimics Semaglutide

13:35 — Why Your Gut Is The Real GLP-1 Factory

14:18 — Top 10 Foods That Naturally Activate GLP-1

19:16 — Best Supplements For GLP-1, Insulin & Blood Sugar

25:07 — Fermented Foods, Probiotics & Meal Sequencing

26:32 — How GLP-1 Helps Repair Insulin Resistance

28:15 — Berberine: Nature’s Ozempic?

30:35 — The Food-First GLP-1 Protocol

31:45 — Final Takeaways: Activate GLP-1 Naturally

 

DISCLAIMER

This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

 

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What if your thyroid isn’t actually the problem? In this episode, Dr. Josh Redd explains why millions of people are told their labs are “normal” while their immune system, gut, hormones, blood sugar, and inflammation continue driving fatigue, brain fog, weight gain, low testosterone, SIBO, and autoimmune symptoms.

This is the conversation for anyone who has been told “everything looks fine” but still knows something is wrong.

Uncover what’s really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! →  http://mybloodwork.com

 

Thank you to our sponsors!

Sunlighten Sauna: https://get.sunlighten.com/axepodcast

Manukora Manuka Honey: https://manukora.com/axe

Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount

 

Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

 

🎧 Early Access!

Our listeners enjoy every episode before anyone else! Tune in below and join our exclusive group of listeners →

Spotify: https://bit.ly/DrJoshAxeSpotify

Apple Podcast: https://apple.co/3JDvWcS

 

Pre-order my NEW BOOK, Heal Your Cells → https://bit.ly/3QJBcQ5

 

Watch my free training on how to naturally balance your blood sugar and reverse your symptoms → http://DrAxeDiabetesClass.com

 

Discover practical steps you can take today to start healing your thyroid naturally →   http://DrAxeThyroidClass.com

 

If you’re ready to start feeling like yourself again and balance your hormones, take my free class → http://DrAxeHormoneClass.com

 

CONNECT WITH DR. JOSH AXE

Instagram → https://www.instagram.com/drjoshaxe/

Facebook → https://www.facebook.com/DrJoshAxe/

TikTok → https://www.tiktok.com/@thedrjoshaxeshow/

X → https://x.com/drjoshaxe/

LinkedIn → https://www.linkedin.com/in/joshaxe

Website →  http://thehealthinstitute.com

Sign up for my newsletter → https://bit.ly/4oE9Jf3

Ask Dr. Axe → http://speakpipe.com/drjoshaxe 

 

CONNECT WITH GUEST

Instagram → https://www.instagram.com/drjoshredd/

Facebook → https://www.facebook.com/drjoshredd

TikTok →https://www.tiktok.com/@drjoshredd

X → https://x.com/drjoshredd

Website → https://drjoshredd.com/

Book: THE 30-DAY INFLAMMATORY RESET: https://www.simonandschuster.com/books/The-30-Day-Inflammatory-Reset/Josh-Redd/9781668205341

 

00:00 — Why Your “Normal Labs” May Be Missing The Real Problem

00:02:48 Hashimoto’s Disease & The Normal TSH Myth

06:00 — Hashimoto’s, Homocysteine, Vitamin D & Autoimmune Triggers

12:00 — Why Your Thyroid May Not Be The Root Cause

18:00 — The Blood Markers Doctors Often Miss

24:00 — Omega-3 Index, Hydration, Iron & Hidden Fatigue

30:00 — Electrolytes, Adrenals & The Gut-Brain Connection

32:10 — SIBO: Bloating, Brain Fog, Anxiety & Food Sensitivities

36:00 — Vagus Nerve, Gargling, Motility & Parasympathetic Repair

39:21 — Low Testosterone, Libido, Muscle Loss & Male Hormone Collapse

45:43 — Stem Cells, PRP, Peptides & Chronic Joint Pain

50:50 — Who Should Consider Peptides — And Who Should Avoid Them

52:59 — Maximum Longevity Protocol: Tests, Hormones & Regenerative Medicine

57:00 — Budget Health Protocol: The Most Important Labs & Supplements

1:02:00 — Mold, Chronic Infections, Long COVID & Environmental Triggers

1:04:00 — Ozone IVs, Plasma Exchange & Microplastics

1:05:20 — Dr. Josh Redd’s Final Takeaways

 

DISCLAIMER

This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

 

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What if the anxiety, brain fog, cravings, and inflammation you’re trying to fix didn’t start in your brain, hormones, or immune system — but in the trillions of bacteria living inside your gut? In this episode, Dr. Josh Axe reveals the hidden chain reaction that can begin with low fiber, antibiotics, stress, and ultra-processed food — and may end in leaky gut, poor nutrient absorption, mood issues, obesity, autoimmune disease, and chronic inflammation.

 

Uncover what’s really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism— plus a 1-hour consultation with a Senior Health Advisor! →  http://mybloodwork.com

 

Download the FREE Gut Healing Guide: https://bit.ly/draxegutreset

 

Thank you to our sponsors!

Sunlighten Sauna: https://get.sunlighten.com/axepodcast

Manukora Manuka Honey: https://manukora.com/axe

Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount

 

Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1

 

🎧 Early Access!

Our listeners enjoy every episode before anyone else! Tune in below and join our exclusive group of listeners →

Spotify: https://bit.ly/DrJoshAxeSpotify

Apple Podcast: https://apple.co/3JDvWcS

 

Pre-order my NEW BOOK, Heal Your Cells → https://bit.ly/3QJBcQ5

 

Watch my free training on how to naturally balance your blood sugar and reverse your symptoms → http://DrAxeDiabetesClass.com

 

Discover practical steps you can take today to start healing your thyroid naturally →   http://DrAxeThyroidClass.com

 

If you’re ready to start feeling like yourself again and balance your hormones, take my free class → http://DrAxeHormoneClass.com

 

CONNECT WITH DR. JOSH AXE

Instagram → https://www.instagram.com/drjoshaxe/

Facebook → https://www.facebook.com/DrJoshAxe/

TikTok → https://www.tiktok.com/@thedrjoshaxeshow/

X → https://x.com/drjoshaxe/

LinkedIn → https://www.linkedin.com/in/joshaxe

Website →  http://thehealthinstitute.com

Sign up for my newsletter → https://bit.ly/4oE9Jf3

Ask Dr. Axe → http://speakpipe.com/drjoshaxe 

 

 

00:00 – The Trillion-Microbe Paradox: You Are Outnumbered Inside Your Own Body

00:55 – The Root Cause of Anxiety, Brain Fog, & Bloating

06:35 – The Hidden Organ: What Your Gut Microbiome Actually Does

12:40 – The Fermentation Cascade: How Your Body Creates Short-Chain Fatty Acids

18:24 – The Gut-Brain Axis: How Bacteria Control Your Vagus Nerve

21:37 – Reversing Dysbiosis: Healthy vs. Disbiotic Gut Profiles

25:58 – The 6 Diversity Killers & The 4-Day Antibiotic Trap

31:25 – The Glyphosate Threat: How Non-Organic Foods Kill Good Bacteria

33:15 – Fecal Microbiota Transplant (FMT): The Cutting-Edge Ecosystem Reset

36:00 – The 30-Plant Protocol & Master Supplement Blueprint

41:23 – The Timeline: How Fast Can Your Gut Microbiome Completely Change?

44:37 – Rapid Fire Q&A: Leaky Gut, Artificial Sweeteners, & Histamine Reactions

49:16 – The 4 Critical Takeaways & Free Gut Reset Protocol

 

 

DISCLAIMER

This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

 

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Many people are doing all the "right" things—eating healthy, taking supplements, exercising, and prioritizing sleep—yet still struggle with chronic fatigue, brain fog, inflammation, digestive issues, hormone imbalances, skin problems, and unexplained symptoms. What if the real culprit is a hidden infection?

In this episode of The Dr. Josh Axe Show, Dr. Josh Axe sits down with Dr. Chris Motley to uncover how chronic infections can quietly impact nearly every system in the body. Together, they explore the connection between mold toxicity, Lyme disease, parasites, Candida overgrowth, H. pylori, viruses, and other hidden pathogens—and how these infections may be contributing to symptoms that conventional testing often overlooks.

You'll learn how infections affect the brain, gut, thyroid, immune system, hormones, and metabolism, along with practical natural strategies to support healing. Dr. Motley shares insights on herbal protocols, targeted nutrition, detoxification support, immune-strengthening therapies, and lifestyle practices designed to help address root causes and restore health from the inside out.

If you've been searching for answers to persistent symptoms and want to better understand the hidden factors that may be impacting your health, this conversation is packed with valuable insights and actionable takeaways.

Uncover what’s really going on in your body with advanced biomarker testing for hormones, thyroid, and metabolism—plus a 1-hour consultation with a Senior Health Advisor! → http://mybloodwork.com

 

Thank you to our sponsors!

 

Sunlighten Sauna: https://get.sunlighten.com/axepodcast

 

Manukora Manuka Honey: https://manukora.com/axe

 

Caraway Home: carawayhome.com/drjoshaxe (Use code DRJOSHAXE) for an exclusive discount

 

Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube:

https://www.youtube.com/@drjoshaxe?sub_confirmation=1

 

🎧 Early Access!

Our listeners enjoy every episode before anyone else! Tune in below and join our exclusive group of listeners →

 

Spotify: https://bit.ly/DrJoshAxeSpotify

 

Apple Podcasts: https://apple.co/3JDvWcS

 

Pre-order my NEW BOOK, Heal Your Cells → https://bit.ly/3QJBcQ5

 

Watch my free training on how to naturally balance your blood sugar and reverse your symptoms → http://DrAxeDiabetesClass.com

 

Discover practical steps you can take today to start healing your thyroid naturally → http://DrAxeThyroidClass.com

 

If you're ready to start feeling like yourself again and balance your hormones, take my free class → http://DrAxeHormoneClass.com

 

CONNECT WITH DR. JOSH AXE

Instagram → https://www.instagram.com/drjoshaxe/

Facebook → https://www.facebook.com/DrJoshAxe/

TikTok → https://www.tiktok.com/@thedrjoshaxeshow/

X → https://x.com/drjoshaxe/

LinkedIn → https://www.linkedin.com/in/joshaxe

Website → http://thehealthinstitute.com

 

Sign up for my newsletter → https://bit.ly/4oE9Jf3

 

Ask Dr. Axe → http://speakpipe.com/drjoshaxe

 

CONNECT WITH DR. CHRIS MOTLEY

Instagram → https://www.instagram.com/doctormotley/

Website → https://doctormotley.com

 

TIMESTAMPS:

0:00 Hidden Infections Are More Common Than You Think

0:55 Why Brain Fog, Fatigue & Hormone Issues May Be Infection-Driven

2:25 The Most Overlooked Chronic Infections Today

4:30 How Mold Damages Your Cells & Mitochondria

6:45 Mold Toxicity, Methylation & Detox Pathways

8:50 Lyme Disease and Neurological Symptoms

11:00 Why Chronic Infections Often Go Undiagnosed

13:05 The Warning Signs of Parasites

14:50 H. Pylori, Candida & Gut Infections Explained

17:20 Histamine Reactions and Hidden Pathogens

18:25 Epstein-Barr Virus, Thyroid Disease & Autoimmunity

19:30 How Infections Affect Blood Flow & Circulation

21:45 The Connection Between Stress Hormones & Infection

23:50 Why Air Purifiers Alone Won't Solve Mold Illness

26:10 Natural Herbs for Parasites, Lyme & Chronic Infections

30:05 Healing the Gut After Infection

34:15 How Pathogens Impact the Brain

38:40 The Best Testing for Mold, Lyme & Parasites

43:20 Detox Strategies That Actually Work

47:10 Rebuilding the Immune System Naturally

50:45 How to Prevent Chronic Infections from Returning

54:00 Final Thoughts on Root-Cause Healing

 

DISCLAIMER This content is strictly the opinion of Dr. Josh Axe and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. Axe nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

 

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