In his weekly clinical update, Dr. Griffin discusses wastewater surveillance data as a complement to emergency department visit data for tracking the incidence of influenza A and RSV, chatbot-delivered online intervention to promote seasonal Influenza vaccination during the COVID-19 pandemic, temporal assessment of disparities in California COVID-19 mortality by industry, modeling the impact of a high-uptake bivalent booster scenario on the COVID-19 burden and healthcare costs in New York City, can high COVID-19 vaccination rates in adults help protect unvaccinated children, Nirmatrelvir/Ritonavir use and hospitalizations or death in previously uninfected non-hospitalized high-risk population with COVID-19, Optimal duration of systemic corticosteroids in COVID-19 treatment, and vaccination after developing long COVID. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Wastewater surveillance data as a complement to tracking incidence of influenza A and RSV (CDC) Chatbot-delivered online intervention to promote seasonal influenza vaccination (JAMA) Temporal assessment of disparities in California COVID-19 mortality by industry (AOE) CDC/HICPAC’s plan to weaken guidance for health care respiratory protection and infection control (NNU) Modelling the impact of a high-uptake bivalent booster scenario on COVID-19 burden (The Lancet) Can high COVID-19 vaccination rates in adults help protect unvaccinated children? (ES) Paxlovid use and hospitalizations or death in previously uninfected high-risk population with COVID-19 (JID) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Vaccination after developing long COVID (IJID) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1046 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

TWiV reviews a Lassa virus mRNA vaccine that confers protection against disease without inducing neutralizing antibodies, and a CRISPR-based method for engineering the genome of RNA viruses. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Angela Mingarelli Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) Virologist Bob Lamb dies (Northwestern Now) Lassa virus mRNA vaccine (Nat Commun) CRISPR engineering of RNA viruses (Sci Adv) Letters read on TWiV 1045 Timestamps by Jolene. Thanks! Weekly Picks Angela – More than 5,000 new species discovered in Pacific deep-sea mining hotspot (journal article) Brianne – The story of our universe may be starting to unravel Rich – Sunlight Changes Unequally All Year Long Alan – Arm swing asymmetry in overground walking Vincent – The Farm at the Javits Center Listener Pick Asal – Ig Nobel Prizes honor zombie spiders, rock-licking scientists, and a clever commode Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses the immunogenicity and reactogenicity of coadministration of COVID-19 and Influenza vaccines, interim effectiveness estimates of 2023 southern hemisphere influenza vaccines in preventing Influenza-associated hospitalizations, genome-wide association study of susceptibility to RSV hospitalization in young children Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Immunogenicity and reactogenicity of coadministration of COVID-19 and Influenza vaccines (JAMA) Effectiveness estimates of Influenza vaccines in preventing associated hospitalizations (CDC) Genome-wide association study of susceptibility to RSV hospitalization in children (JID) Performance of rapid antigen tests to detect SARS-CoV-2 infection (AIN) Safety and immunogenicity of XBB.1.5-containing mRNA vaccines (medRxiv) C.D.C. director explains why you should get the latest Covid booster (Nytimes) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Timing and predictors of loss of infectivity among healthcare workers with COVID-19 (CID) Effect of famotidine on cognitive and behavioral dysfunctions induced in post-COVID-19 infection (JPR) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1044 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]

From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Marion Koopmans about COVID-19, Mpox, H5N1 and polio, and the promise of a One Health approach to prevent outbreaks, epidemics, and pandemics. Host: Vincent Racaniello Guest: Marion Koopmans Click arrow to play Download TWiV 1043 (45 MB .mp3, 62 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) SARS-CoV-2 variants in Rotterdam wastewater (Sci Tot Environ) SARS-CoV-2 in mink and other animals (Transbound Emerg Dis) Mpox in Netherlands (EuroSurveill) Divergent SARS-CoV-2 in immunocompromised patient (Emerg Inf Dis) Accelerated SARS-CoV-2 evolution in deer (Nat Commun) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected]

In his weekly clinical update, Dr. Griffin discusses China’s health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization, temporal changes in fecal microbiota of patients infected with COVID-19, and long-term survival after intensive care for COVID-19. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode China’s health authorities fight surge in cases of unknown origin (BMJ) Analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses (ASHE) Prevalence and outcomes of co-infection between SARS-CoV-2 and influenza (IJID) Comparison of bivalent and monovalent mRNA vaccine boosters (CID) Optimal duration of systemic corticosteroids in COVID-19 treatment (OFID) Acute blood biomarker profiles predict cognitive deficits after COVID-19 hospitalization (Nature) Temporal changes in fecal microbiota of patients infected with COVID-19 (BMC) Long-term survival after intensive care for COVID-19 (AIC) Contribute to our Floating Doctors fundraiser at PWB Letters read on TWiV 1042 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected]