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Fat Science

Dr Emily Cooper
Fat Science
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  • GLP-1s: Will I Have to Take Them Forever?
    This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright break down the latest science behind GLP-1 medications like Ozempic, Wegovy, and Mounjaro. Dr. Cooper shares her decades of expertise on how these drugs work, their evolution, and whether you really have to take them for life. The episode dives deep into the individual factors that impact tapering off, the importance of metabolic signals (like famine and security signals), and why medication is just one piece of the metabolic puzzle. Key Takeaways:GLP-1 medications have advanced significantly, with more convenient dosing and greater effectiveness for many—but responses vary widely from patient to patient.Weight on the scale isn’t the only measure; body composition, nutrient levels, and metabolic markers are critical in determining treatment and possible tapering.Not everyone needs to take GLP-1s forever—tapering is possible, but it depends on individual health markers, genetics, and whether metabolic signals are balanced.The future of metabolic health lies in combination therapies that target multiple pathways, not just GLP-1s.Dieting alone disrupts metabolic signals, making professional metabolic medicine and nutrition guidance essential for long-term health.Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
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  • Dosing Download: How much? When? Is It Working?
    Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science as they unpack the complexities of dosing GLP-1 medications for metabolic health and weight management. Dr. Cooper emphasizes the importance of an individualized approach, debunking the myth that higher doses or faster titration always lead to better outcomes. The team addresses listener questions about how and when to increase doses, highlight the risks of rapid escalation, and discuss the nuanced ways these drugs impact metabolic health beyond just weight loss. Real-life experiences and thoughtful, science-backed guidance will help you navigate your own journey with metabolic dysfunction and medication.Key Takeaways:Dosing of GLP-1 medications should always be tailored to the individual, considering response, side effects, and other health factors—not just the speed of weight loss.Starting at the lowest dose and titrating slowly increases medication tolerance and long-term effectiveness.Lab markers such as A1C, glucose, cholesterol, and muscle mass are key indicators in determining if the medication and dosing are "working."Rapidly escalating to the highest dose can backfire, causing side effects and limiting future treatment options.Dieting mindsets and using medication solely as an appetite suppressant can lead to loss of lean mass and suboptimal health outcomes.Ongoing patient-provider relationships and regular lab work ensure medication strategies remain safe and effective.Personal Stories & Practical Advice:Andrea reflects on her initial desire for quick fixes and shares lessons learned about patience, nourishment, and long-term progress. Mark discusses insurance-driven medication switches and finding the “sweet spot” for dosing with Dr. Cooper’s guidance.Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
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  • Mailbag: Your Questions Answered
    Join Dr. Emily Cooper, Andrea Taylor, and Mark Wright on Fat Science for a special mailbag episode answering listener questions about metabolic health. Dr. Cooper explains the difference between mindful and mechanical (timed) eating, especially for those using medications like Zepbound. The team also addresses emotional challenges tied to frequent eating, societal fat shaming, and the complexities of medication side effects for those on GLP-1 agonists and antipsychotics. Real experiences and practical advice help shed light on fueling your body, breaking free from diet culture guilt, and navigating complex emotions on the journey to better health.Key Takeaways:GLP-1 medications like Zepbound affect appetite and metabolism but can also suppress hunger cues; mechanical eating—timing meals and including all food groups—prevents nutritional deficits and supports long-term metabolic health.Eating too few calories, even when appetite is low, can be detrimental; mechanical eating helps maintain muscle mass and prevent stalled metabolism.Emotional barriers, guilt, and anxiety around food are common due to fat shaming and past dieting experiences. Meal planning and support from dietitians can help ease this transition.GLP-1s may alter medication absorption or trigger anxiety episodes due to blood sugar fluctuations; monitoring and professional advice are recommended when combining with psych meds.Personal Stories & Practical Advice:Andrea shares strategies for getting enough nutrition when appetite is low, her experiences with fat shaming, and her approach to enjoying food without guilt.Mark and Dr. Cooper discuss breaking free from restrictive food mindsets and building a positive, fuel-focused relationship with eating.Key Takeaways:Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
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  • Starved For Answers: The Fallout of Federal Science Cuts
    This week on Fat Science, Dr. Emily Cooper, Andrea Taylor and Mark Wright tackle the urgent issue of deep funding cuts to scientific research in the United States. Dr. Cooper shares firsthand insight on how these changes are affecting patient care and scientific integrity, highlighting the pressures researchers face—including censorship and loss of resources at institutions like the NIH. The conversation sheds light on how misinformation, government interference, and reduced diversity in studies threaten the future of metabolic, cancer and public health research. Listeners will better understand why research matters for everyday health, and what’s at stake when critical projects lose funding.Key Takeaways:Sweeping research cuts at major institutions like NIH jeopardize progress in areas like metabolic health, cancer, ALS, heart disease, and Alzheimer’s.Researchers are facing censorship and pressure to alter or suppress scientific findings in nutrition, autism, and vaccine research.Reducing diversity in research undermines scientific accuracy and inclusivity, risking treatments that don’t address the needs of all populations.Slashed funding will stall new medical discoveries, limit future treatment options, and may have consequences for decades to come.Misinformation around vaccines and public health is rising as government agencies are pressured to alter or hide true scientific data.Resources:Links: Current Medical ReportingVin Gupta, MD Nutrition InformationNutrition for Mortals Podcast with Dietitians: Matt and Jen Infectious Diseases, ImmunizationsMaria Van Kerkhove - WHOJeff DuchinMichael Osterholm, CIDRAP Kevin Hall ResearchKevin Hall on LinkedIn Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, send an email to dr.c@fatsciencepodcast.com. If you have a show idea, feedback, or just want to connect, you can also reach us us atinfo@diabesityinstitute.org.Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
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  • Blood Fats: The Good, the Bad & the Ugly
    This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright dive into the world of blood fats—unpacking what cholesterol numbers really mean for your health. They break down HDL (the “good” cholesterol), LDL (the “bad” cholesterol), triglycerides, and spotlight the often-overlooked lipoprotein(a), a genetic risk marker with significant consequences for heart health. The team dispels myths about fats in our diet, covers the impact of lifestyle and genetics, and explores how advanced testing can reveal hidden risks. You’ll come away understanding which fats matter most, why particle size counts, and what actions can help manage your numbers and protect your heart.Key Takeaways:Blood fats, specifically HDL, LDL, and triglycerides, are critical indicators of cardiovascular risk. Advanced testing can identify dangerous subtypes and genetic markers like lipoprotein(a) that standard panels miss.HDL has benefits, but high numbers don’t cancel out high LDL; LDL particle size and count are crucial—small, dense particles are more harmful.Lipoprotein(a) is a major genetic risk factor for heart disease and stroke that isn’t modifiable by diet or exercise; new treatments are in development.Plant-based monounsaturated fats (like olive oil and avocados), resistant starches, and soluble fiber offer metabolic and heart-health benefits, but even perfect diets may not lower genetic cholesterol risks.Lifestyle factors—exercise, avoiding smoking, quality sleep, and managing conditions like diabetes—are critical for reducing cardiovascular risk, especially if you have inherited risk markers.Heart health isn’t just about body size—“looking healthy” doesn’t guarantee healthy arteries; everyone should know their numbers and consider advanced heart scans as needed.Resources:Connect with Dr. Emily Cooper on LinkedIn.Connect with Mark Wright on LinkedIn.Connect with Andrea Taylor on Instagram.Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.If you have a question for Dr. Cooper, send an email to dr.c@fatsciencepodcast.com. If you have a show idea, feedback, or just want to connect, you can also reach us us at info@diabesityinstitute.org.Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/
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About Fat Science

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go (and stay!) away. In each episode, we share little-known facts and personal experiences to dispel misconceptions, reduce stigma, and instill hope. Fat Science is committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.
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