Breathwork: Pulmonary Hypertension with Professor Sean Gaine (Part 2)
This week, we’re joined by Professor Seán Gaine, Ireland’s foremost expert in pulmonary hypertension. In this insightful episode, he shares his expert perspective on the diagnosis, classification, and clinical presentation of the condition, as well as the latest advances in treatment.
A must-listen for all healthcare professionals, Professor Gaine also discusses when to suspect pulmonary hypertension and highlights the nuances in the management of patients with pulmonary hypertension. Don’t miss this opportunity to learn from a global leader in the field.
Chapters
0:52 Rapid fire round on pulmonary hypertension
01:42 Definition of pulmonary hypertension
02:08 Signs and symptoms of pulmonary hypertension
02:56 Five groups of pulmonary hypertension
03:33 Group 1 pulmonary hypertension: Pulmonary arterial hypertension
04:34 Group 2 pulmonary hypertension: Left heart disease
05:23 Group 3 pulmonary hypertension: Chronic lung disease/hypoxia
05:58 Group 4 pulmonary hypertension: Pulmonary vascular obstruction
06:30 Group 5 pulmonary hypertension: Miscellaneous
07:25 Referral to the national pulmonary hypertension centre: right heart catheterisation
09:37 Work up in the pulmonary hypertension clinic
11:06 Risk stratification in pulmonary hypertension
12:06 Diagnostic criteria pulmonary hypertension
Dynamic testing right heart catheterisation: Cardiopulmonary exercise testing Reliability of right heart catheterisation
Treatment algorithm in pulmonary arterial hypertension Tripple therapy for high risk patients
Double combination therapy for non-high risk patients
Fourth treatment pathway, Quadruple therapy?: Sotatercept - an activin
scavenger Treatment options for groups 4 pulmonary hypertension: Balloon pulmonary angioplasty
Treatment options for groups 2, 3 and 5
Side effects of triple therapy
Lung transplant in pulmonary hypertension: Double or single lung transplant
Pitfalls in the acute management of patients with pulmonary hypertension
Interpretation of the B Natriuretic Peptide level
Medications contraindicated pulmonary hypertensions
Outcomes in pulmonary hypertension
Take home message on pulmonary hypertension
Show Notes
- https://lumen5.com/user/edofficer/sotatercept-emergin-d5jg6/
- Irish Thoracic Society Flashcard Pulmonary Hypertension
https://irishthoracicsociety.com/wp-content/uploads/2021/06/5.-Pulmonary-Hypertension.pdf
- Benza RL, Kanwar MK, Raina A, et al. Development and validation of an abridged version of the REVEAL 2.0 risk score calculator, REVEAL Lite 2, for use in patients with pulmonary arterial hypertension. Chest 2021; 159: 337–346.
- Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. European Respiratory Journal. 2022:2200879.
DOI: https://doi.org/10.1183/13993003.00879-2022
- Chin KM, Gaine SP, Gerges C, Jing Z-C, Mathai SC, Tamura Y, et al. Treatment algorithm for pulmonary arterial hypertension. European Respiratory Journal. 2024;64(4):2401325. DOI: https://doi.org/10.1183/13993003.01325-2024
- Hoeper, M.M., Badesch, D.B., Ghofrani, H.A., Gibbs, J.S.R., GombergMaitland, M., McLaughlin, V.V. et al. (2023) ‘Phase 3 trial of sotatercept for treatment of pulmonary arterial hypertension’, New England Journal of Medicine, 388(17), pp. 1478–1490. Available at:
https://doi.org/10.1056/NEJMoa2213558
- Humbert M, McLaughlin VV, Badesch DB, Ghofrani HA, Gibbs JSR, Gomberg-Maitland M, et al. Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death. N Engl J Med. 2025;392(20):1987-2000. DOI: 10.1056/NEJMoa2415160
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