Flex Diet Podcast

In this episode of the Flex Diet Podcast, I sit down with Dr. Scott Sherr to take a deep dive into methylene blue, mitochondrial function, and where the truth lies between online hype and fear. We talk through how methylene blue acts as a redox cycler in the mitochondria, how dosing differs for mitochondrial support versus antimicrobial use, and why high doses or poorly labeled liquid droppers can cause problems. 

Dr. Sherr also shares how he’s used methylene blue with athletes for recovery and endurance, including timing, half-life, and practical ranges he sees most often. We cover how mitochondrial health connects to energy, mood, focus, stress physiology, and recovery, plus resources from Transcriptions and the Health Optimization Medicine and Practice (HOMe/HOPe) framework.

Sponsors:

TROScriptions TX: https://troscriptions.com/?rfsn=9054607.066ddde&utm_source=refersion&utm_medium=affiliate&utm_campaign=9054607.066ddde

CODE: DRMIKE



Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8

Coming up:

ISSN 2026: https://www.sportsnutritionsociety.org/

Available now:

Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.

Episode Chapters:

03:11 Why Methylene Blue Now

04:29 Scott Cher Origin Story

05:05 Health Optimization Framework

07:08 Transcriptions and Safe Sourcing

08:46 Natural vs Synthetic Debate

11:49 How Methylene Blue Works

17:42 Who Benefits Most

22:13 Athletic Performance and Recovery

29:41 Dosing Timing and MAOI Effects

32:13 Mitochondria and Fertility

32:28 Energy Anxiety and Brain Fog

33:13 Depression Beyond Serotonin

35:30 Stress Pathways and Cell Danger

37:00 ADHD or Sympathetic Overdrive

38:50 Recovery Metrics and Downregulation

42:21 GABA Support and BBB Clues

47:50 Building Mitochondrial Capacity First

51:35 Methylene Blue Dosing Guide

57:54 Where to Learn More

01:00:24 Podcast Wrap and Disclaimer 

Flex Diet Podcasts you may enjoy:

Episode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil Batterson

YouTube: https://www.youtube.com/watch?v=PPZyO1nxSPA



Episode 320: Unlocking Mitochondrial Secrets with Dr. Hemal Patel

YouTube: https://www.youtube.com/watch?v=lQGXtZjJtQw



Connect with Dr Sherr:

Instagram: https://www.instagram.com/drscottsherr/

Website: https://drscottsherr.com/

YouTube: https://www.youtube.com/@drscottsherr

Get In Touch with Dr Mike:

Instagram: Drmiketnelson

YouTube: @flexdietcert

Email: Miketnelson.com/contact-us

In this episode of the Flex Diet Podcast, I sit down with Dr. Masha Makeeva, a physician specializing in integrative and regenerative medicine, to get a clear, practical breakdown of hyperbaric oxygen therapy. We talk about why HBOT’s biggest benefit may be reducing inflammation, who it can help most, and how to think about protocols — pressure, oxygen concentration, session length, frequency, and total number of sessions —so you’re not comparing totally different approaches. 

We also dig into where she sees HBOT used most (including cancer support and professional sports), why solid tumors may respond differently than blood cancers, and how HBOT can support recovery and quality of life during treatment. We cover safety, home chamber considerations, and how mitochondrial and metabolic health, HRV, and downregulation all fit into better outcomes.

Sponsors:

Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8

Coming up:

ISSN 2026: https://www.sportsnutritionsociety.org/

Available now:

Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.

Episode Chapters:

02:26 Why Hyperbaric Works

03:50 What Inflammation Means

07:32 Tracking Inflammation Markers

10:57 Avoiding Over Testing

16:19 Who Uses Hyperbaric

19:57 Hyperbaric for Cancer

27:38 Protocol Variables Explained

34:38 Science Meets Clinical Art

37:31 Access and Chamber Limits

37:56 Constraints Led Programming

39:27 Home Hyperbaric Boom

40:12 Safety Training And Side Effects

44:55 Performance Versus Recovery

48:08 Oxygen Brain And Mitochondria

52:19 Downregulation After Sessions

56:55 CO2 Therapy And Medical Gases

01:02:17 Hydrogen Therapy Basics

01:04:32 Where To Find Dr Masha

01:07:20 Podcast Wrap Up And Disclaimer

Flex Diet Podcasts you may enjoy:

Episode 362: Maximizing Athletic Performance and Recovery with Dr. Jeremy Bettle

YouTube: https://www.youtube.com/watch?v=gj_nWeQhs0s



Episode 350: From Halo to Flow: The Future of Brain Performance Tech w/ Erin Lee of Flow Neuroscience

YouTube: https://www.youtube.com/watch?v=7YT_7YWPQX4



Connect with Dr Makeeva:

Instagram: https://www.instagram.com/how_to_hyperbaric/

Website: https://drmasha.com/

Get In Touch with Dr Mike:

Instagram: Drmiketnelson

YouTube: @flexdietcert

Email: Miketnelson.com/contact-us

A physician buddy asked me whether the general population should focus on cardio or lifting — and I wanted to share my answer with you. In this solo cast, I break down why cardio and resistance training produce different adaptations, offer my go-to weekly framework for getting started, and talk about zone two training, high-intensity intervals, VO2 max assessments, and why compliance beats the perfect program every time. Plus, the Flexible Meathead Cardio Course is open for enrollment through Wednesday.

Sponsors:

Fitness Insider Newsletter: https://miketnelson.com/

Enroll in the Flexible Meathead Cardio course. Enrollment ends Wednesday, April 1, at midnight PST.

https://miket.me/cardio

Available now:

Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.

Episode Chapters:

01:11 The Cardio vs Lifting Question

01:29 Research Case for Lifting

03:02 Short Answer Do Both

03:34 Context Matters and Zone 2

04:24 Compliance and Daily Steps

04:57 Can Lifting Improve Cardio

06:23 Simple Weekly Training Split

07:29 Adding HIIT for VO2

10:16 Assessing VO2 Max Baseline

12:13 Limits of Metcon for Cardio

14:14 Practical Template and Retesting

15:45 Zone 2 Nuance and Wrap Up

Get In Touch with Dr Mike:

Instagram: Drmiketnelson

YouTube: @flexdietcert

Email: Miketnelson.com/contact-us

In this episode of the Flex Diet Podcast, I sit down with my friend Kristi Storoschuk, a PhD candidate in exercise physiology, to unpack her review paper on zone 2 cardio and what the evidence actually shows. We dig into what “zone 2” really means (including lactate thresholds and why common proxies like heart rate and the talk test can miss the mark), where the 80/20 endurance model came from, and why messaging around zone 2 for mitochondrial function, fat oxidation, metabolic flexibility, and health may be overstated, especially for the general population. 

Kristi explains why higher intensities often produce equal or better mitochondrial and performance-related adaptations, how training volume and population context change the conversation, and where low-intensity work like walking may still fit.

Sponsors:

Flex 4:  Kristi's Top 4 tips for improving aerobic fitness as a recreational lifter: https://flex-diet.kit.com/17ac1beade

Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8

Coming up:

ISSN 2026: https://www.sportsnutritionsociety.org/

Available now:

Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.

Episode Chapters:

04:04 Why Zone Two Went Viral

09:40 Defining Zone Two Lactate

14:15 Talk Test and Practical Limits

16:43 Does Zone Two Even Matter

21:08 The 80/20 Misapplied

26:14 Origins of Base Training

32:06 Mitochondria Volume vs Intensity

40:08 How Myths Persist Online

44:16 Zone Three Over Zone Two

44:46 Why Some Recover Faster

45:37 Overtraining Study Lessons

49:59 Listen To Output Signals

52:20 How Often To Train

54:42 Short Daily Progressives

57:46 Tabata Reality Check

01:00:19 Walking And Health Outcomes

01:05:23 Mitochondria Versus Performance

01:08:04 Lactate Threshold Beats VO2

01:12:43 Fueling And Final Wrap

01:14:33 Podcast Outro And Disclaimer

Flex Diet Podcasts you may enjoy:

Episode 360: Exploring Aerobic Development & Concurrent Training with Jason Brown

YouTube: https://www.youtube.com/watch?v=lkqim0EDfec&t=4s



Episode 269: From Mitochondria to Metabolic Health Insights with PhD Candidate Kristi Storoschuk

YouTube: https://www.youtube.com/watch?v=T9EFRluKt6Q



Connect with :

Instagram: https://www.instagram.com/krististoroschuk/

Website: https://krististoroschuk.com/

Get In Touch with Dr Mike:

Instagram: Drmiketnelson

YouTube: @flexdietcert

Email: Miketnelson.com/contact-us

In this episode of the Flex Diet Podcast, I sit down with coach Kevin Dineen to talk about where fitness and healthcare are headed and whether their merger is a net positive or negative. We dig into why people still default to asking physicians about training and nutrition, the problems created by siloed systems, and what a more client-centered model could look like with coaches, PTs, massage therapists, and physicians collaborating under one roof. 

We also discuss the pros, cons, and liability concerns around coaches using blood work for performance, how hard training can skew lab results, and why basic habits like lifting, cardio, steps, and community support matter more than expensive supplement stacks. Kevin closes with key advice for newer coaches: professionalism, mentorship, travel to learn standards, and clarifying your “why.”

Sponsors:

Flex4: Kevin's top 4 things new coaches can do to get better at their craft: https://flex-diet.kit.com/17ac1beade

Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8

Check out:

Real Coaches Summit 2026: https://realcoachessummit.com

Available now:

Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.

Episode Chapters:

04:42 Kevin Joins the Show

05:47 Peter Attia and Doctor Pedestals

10:01 Broken System and Referrals

13:06 Client First Collaboration Model

16:59 Trainer Centered Prevention

19:05 All-in-One Gym Healthcare Hub

23:33 Pricing Niche and Community

28:23 Supplement Hype vs Basics

34:15 Movement Over Nutrition Debate

35:16 Blood Work Timing and Context

38:01 Community Keeps You Honest

39:11 Programming Phases And Deficits

39:56 Blood Work As A Service

42:18 Leveling Up With Truth

44:48 Assessments Without Shame

47:00 Do The Obvious Work

52:15 Experience Finds Hidden Links

55:02 Licensing Versus Professionalism

01:00:52 Business Skills Raise The Bar

01:04:17 Where To Find Kevin

01:05:29 Listener Wrap Up 

Flex Diet Podcast you may enjoy:

Episode 295: Future of Coaching, Humanizing Your Brand, and the Rise of AI with Mike Doehla

YouTube: https://www.youtube.com/watch?v=zB1Pa51OW3o&t=2s



Connect with :

Instagram: https://www.instagram.com/coachkevdineen

Website: https://structurepf.com/

Get In Touch with Dr Mike:

Instagram: Drmiketnelson

YouTube: @flexdietcert

Email: Miketnelson.com/contact-us