Docs Who Lift

• Semaglutide vs. Tirzepatide: Are We Closing the Gap?

  How the STEP-UP trial came to life,  and what made the 7.2mg dose possibleWhat the data actually says about weight loss and side effects at higher dosesWhy trial design, pharmacokinetics, and estimands matter more than you thinkWhat’s coming next in obesity meds: duals, triples, and even antagonistsThe real talk on intermittent fasting, access issues, and preaching vs. scienceSign up for Dr. Spencer''s Clinic

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• Clinical vs Anthropometric Obesity

  TakeawaysThe study examines the overlap between clinical and anthropometric obesity.Anthropometric measures include waist circumference, waist-to-hip ratio, and BMI.Challenges exist in applying the Lancet Commission's definitions in clinical practice.Metabolically healthy obesity is a debated topic in obesity research.The study highlights the importance of data from the All of Us Research Program.There is a significant prevalence of preclinical obesity in individuals with normal BMI.The classification of obesity may need to shift focus towards overweight individuals.The study's findings suggest a need for more nuanced definitions of obesity-related diseases.Future research will explore the transition from preclinical to clinical obesity.The conversation emphasizes the importance of real-world data in understanding obesity.Click here to see the studyFollow Dr. Yao on X hereFollow Dr. Blaha on X here Click here to join Dr. Spencer's online clinic  

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• GLP-1 meds and macular degeneration

  Learn what age-related macular degeneration (AMD) isWhat causes AMDThe types of AMDThe update on NAION - listen to last year's podcast all about itWhy we aren't too concernedClick here to join Dr. Spencer's online clinic VineyardClick to read the JAMA AMD articleClick to read the Ophthalmology journal AMD article

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• Menopause, MHT, and GLP-1 medicines

  Menopausal hormonal therapy should not be a blanket recommendation for everyone going through menopauseWeight management in women is influenced by hormonal changes throughout life stages.Retrospective analyses can provide insights but have limitations.The wellness industry often oversimplifies complex medical issues.Hormonal replacement therapy may have subtle benefits for weight management.Confounding factors like SSRIs can complicate weight loss efforts.A holistic approach is essential for managing women's health during menopause.Education and awareness are crucial for women navigating menopause.Future research should focus on randomized controlled trials for better clarity.Understanding individual patient experiences is key to effective treatment.Click here to see her studyClick here to follow Dr. Tchang on XClick here to join Dr. Spencer's clinic Vineyard 

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• The Science of Myostatin inhibitors, GLP-1 meds and Muscle Mass

  Dr. Grant Tinsley joins the discussion as the body composition expert.Myostatin is a key regulator of muscle growth.Wendy Whippete the most jacked muscled up dogThe concern of GLP-1 receptor agonists and muscle mass loss.Overview of Courage trial looking at semaglutide and trevogrumab and lean mass lossUpcoming Believe trial coming out (bimagrumab and semaglutide)Exercise remains crucial for muscle health and function.MRI data from SURPASS MRI provides new insights into muscle volume changes.The combination of medications may have varying effects on muscle mass.Caution is advised regarding the long-term effects of new drugs.Clinical benefits of medications often outweigh concerns about muscle loss.Future research will explore the synergy between exercise and medication.Other docs who lift podcasts with Dr. Grant:Tirzepatide muscle lossLean mass loss and GLP-1 meds

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