From Injections to Pills: Breaking Down the New Oral GLP-1 Data
Show Notes:In this episode of Docs Who Lift, the Nadolsky brothers welcome back Dr. Sean Wharton, clinical trialist and one of the leading researchers behind the next generation of oral GLP-1 medications. Together, they break down:The OASIS-4 trial results on 25mg oral semaglutide and how it stacks up to injectable WegovyHow orforglipron, Eli Lilly’s new small-molecule GLP-1, differs from peptide-based drugsWhy these new therapies could make weight management more accessible and affordableThe fascinating pharmacology behind “snack molecules” and small-molecule receptor agonistsCommon misconceptions about bioavailability, dosing, and side effectsThe potential role of oral GLP-1s for patients with mild obesity or cardiometabolic diseaseWhether you’re a clinician, researcher, or patient curious about the future of obesity medicine, this conversation offers a clear look at how science is shifting toward needle-free solutions.Oasis 1 Trial LinkOasis 4 Trial LinkAttain 1 Trial Link Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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De-Emphasizing BMI, Prioritizing Health: What’s New in the ACE Obesity Guidelines
In this episode of Docs Who Lift, the Nadolsky brothers dive deep into the newly released American Association of Clinical Endocrinology (ACE) Algorithm for Obesity Care led by Dr. Karl himself. They explore:Why ACE moved away from a BMI-only approach to a person-centered, complication-centric modelThe new staging framework (ABCD) that helps individualize treatment intensityHow to interpret “clinical” vs “preclinical” obesity under the new modelUpdated targets for clinically meaningful weight loss (5%, 10%, 15% tiers)The emphasis on resistance training, sleep, and behavioral health alongside nutritionPractical guidance for selecting anti-obesity medications and identifying the right therapy for each patientWhether you’re a clinician, health professional, or patient trying to understand modern obesity care, this episode breaks it all down in a practical, real-world way without the jargon.Youtube Video to follow along the graphic mentioned Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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Debunking The Myths of Metabolism and Weight Loss
TakeawaysThe book aims to dispel myths surrounding the Biggest Loser study.Miscommunication in media has led to public confusion about metabolism.Metabolic adaptation is a response to weight loss, not a determinant of it.Cultural factors significantly influence eating habits and food choices.The food environment plays a crucial role in dietary behaviors.Bipartisan support is necessary for effective food policy changes.Understanding metabolism requires a nuanced approach beyond just calories.The relationship between exercise and metabolism is complex and not fully understood.Appetite signals are a major factor in weight regain after dieting.Education about nutrition science is essential for public understanding.Julia Belluz X/TwitterKevin Hall X/TwitterPurchase Their Book Here Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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Menopause Medicine Meets Obesity Care: Doctors React
Takeaways Menopausal women often prioritize weight gain concerns over other symptoms.The study observed an association between hormone therapy and weight loss with GLP-1 medications.Retrospective studies have limitations but can provide valuable insights.Future research should focus on randomized controlled trials to confirm findings.The relationship between estrogen and GLP-1 signaling needs further exploration.Funding for research can be challenging, especially for early career investigators.Collaboration between different specialties is crucial for comprehensive patient care.The media often misrepresents research findings, leading to misconceptions.Individualized treatment plans are essential for menopausal women.There is a need for more awareness about the effects of menopause on health.Research Links:Weight loss response to semaglutide in postmenopausal women with and without hormone therapy useCombination of obesity medication tirzepatide and menopause hormone therapy fuels weight loss Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
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Women’s Fitness Needs Debate: Dr. Stacy Sims vs. Dr. Lauren Colenso-Semple
We covered:Fasted trainingProtein timingand many more fitness topics!Hear Dr. Lauren Colenso-Semple and Dr. Stacy Sims discuss outcomes versus mechanisms and much moreTap Here for Dr Stacy Sims ReferencesTap Here for Dr. Colenso-Semples ReferencesDr. LCS InstagramDr. SS Instagram Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Drs. Spencer and Karl Nadolsky talk about nutrition, medicine, and fitness through the lens of two physicians who lift weights. Both doctors are former NCAA division 1 wrestlers who have gone into medicine. Dr. Spencer Nadolsky is a board certified family physician specialized in obesity medicine and lipidology. Dr. Karl Nadolsky is a board certified endocrinologist also specialized in obesity medicine.
Ireland