TakeawaysThe study examines the overlap between clinical and anthropometric obesity.Anthropometric measures include waist circumference, waist-to-hip ratio, and BMI.Challenges exist in applying the Lancet Commission's definitions in clinical practice.Metabolically healthy obesity is a debated topic in obesity research.The study highlights the importance of data from the All of Us Research Program.There is a significant prevalence of preclinical obesity in individuals with normal BMI.The classification of obesity may need to shift focus towards overweight individuals.The study's findings suggest a need for more nuanced definitions of obesity-related diseases.Future research will explore the transition from preclinical to clinical obesity.The conversation emphasizes the importance of real-world data in understanding obesity.Click here to see the studyFollow Dr. Yao on X hereFollow Dr. Blaha on X here Click here to join Dr. Spencer's online clinic
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GLP-1 meds and macular degeneration
Learn what age-related macular degeneration (AMD) isWhat causes AMDThe types of AMDThe update on NAION - listen to last year's podcast all about itWhy we aren't too concernedClick here to join Dr. Spencer's online clinic VineyardClick to read the JAMA AMD articleClick to read the Ophthalmology journal AMD article
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Menopause, MHT, and GLP-1 medicines
Menopausal hormonal therapy should not be a blanket recommendation for everyone going through menopauseWeight management in women is influenced by hormonal changes throughout life stages.Retrospective analyses can provide insights but have limitations.The wellness industry often oversimplifies complex medical issues.Hormonal replacement therapy may have subtle benefits for weight management.Confounding factors like SSRIs can complicate weight loss efforts.A holistic approach is essential for managing women's health during menopause.Education and awareness are crucial for women navigating menopause.Future research should focus on randomized controlled trials for better clarity.Understanding individual patient experiences is key to effective treatment.Click here to see her studyClick here to follow Dr. Tchang on XClick here to join Dr. Spencer's clinic Vineyard
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The Science of Myostatin inhibitors, GLP-1 meds and Muscle Mass
Dr. Grant Tinsley joins the discussion as the body composition expert.Myostatin is a key regulator of muscle growth.Wendy Whippete the most jacked muscled up dogThe concern of GLP-1 receptor agonists and muscle mass loss.Overview of Courage trial looking at semaglutide and trevogrumab and lean mass lossUpcoming Believe trial coming out (bimagrumab and semaglutide)Exercise remains crucial for muscle health and function.MRI data from SURPASS MRI provides new insights into muscle volume changes.The combination of medications may have varying effects on muscle mass.Caution is advised regarding the long-term effects of new drugs.Clinical benefits of medications often outweigh concerns about muscle loss.Future research will explore the synergy between exercise and medication.Other docs who lift podcasts with Dr. Grant:Tirzepatide muscle lossLean mass loss and GLP-1 meds
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Current State of Nutrition Research and MAHA
Takeaways:The MAHA report aims to address public health issues but lacks actionable policies.Historical context is crucial for understanding current dietary guidelines.Funding for nutrition research has been inadequate, impacting the quality of data.Public perception of nutrition often outpaces scientific evidence.The evolution of dietary guidelines reflects political and social influences.There is a need for more rigorous nutrition science to inform policy.The dietary guidelines have not significantly improved population health metrics.Political will is essential for implementing effective nutrition policies.Nutrition science faces challenges in funding and research infrastructure.The MAHA report's recommendations may be more performative than substantive. Food policy changes are often superficial and ineffective.There is a significant disconnect between policy and actual health outcomes.Nutrition science is underfunded and lacks high-quality research.Misinformation in nutrition can lead to harmful public health outcomes.The focus on food additives distracts from more pressing issues like obesity.Experts are being sidelined in favor of political agendas.Public trust in health recommendations has eroded post-COVID.Nutrition policies need to be based on solid scientific evidence.The food industry needs clearer guidance on reformulating products.Future nutrition policies must prioritize public health over political gainRead Dr. Kevin's paperFollow Dr. Kevin on instagramJoin Dr. Spencer's clinic
Drs. Spencer and Karl Nadolsky talk about nutrition, medicine, and fitness through the lens of two physicians who lift weights. Both doctors are former NCAA division 1 wrestlers who have gone into medicine. Dr. Spencer Nadolsky is a board certified family physician specialized in obesity medicine and lipidology. Dr. Karl Nadolsky is a board certified endocrinologist also specialized in obesity medicine.
Ireland