The Root Cause Medicine Podcast

• Hard Case? Start Here. Functional Immunology for Complex Cases with Dr. Sam Yanuck

  In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge sits down with functional immunology expert and educator Dr. Samuel Yanuck to explore one of the most overlooked systems in chronic illness: the immune system. With clarity and compassion, Dr. Yanuck breaks down how immune dysregulation can contribute to complex conditions like depression, neuropathy, migraines, chronic fatigue, and even cardiovascular disease. From brain inflammation and mast cell activation to Epstein-Barr virus and mold, Dr. Yanuck offers a new way of thinking about biology—where inflammation isn’t just a symptom, but a system that can be measured, understood, and treated. You’ll here them discuss: - Why immunology could be at the root of nearly every chronic illness - The immune pathways that connect depression, anxiety, brain fog, and fatigue - What PANS, PANDAS, and autoimmune encephalitis really are—and why they’re often misdiagnosed - How gut, brain, and immune health form a feedback loop - The labs you should run if you suspect chronic immune dysfunction - A framework for evaluating chronic viral infections like EBV and CMV - Natural immune modulators: Chinese skullcap, astragalus, quercetin, sulforaphane, and more - Why personalized immune workups—not protocols—create results Guest Bio: Dr. Samuel Yanuck is a functional medicine clinician and expert educator in functional immunology. He is the creator of Cogence Immunology, a comprehensive online training program that has educated over 9,000 clinicians in over 60 countries. His approach blends immunology, clinical experience, and systems thinking to help providers and patients uncover the true drivers of chronic illness. Dr. Yanuck is also the co-founder of the Yanuck Center for Life and Health in North Carolina, where he sees patients and helps clinicians find root-cause solutions to immune dysfunction through mentorship and collaboration. His work is helping reshape how the next generation of practitioners understand inflammation, autoimmunity, and healing. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

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• The Ageless Brain: Dr. Dale Bredesen on Preventing Cognitive Decline

  In this episode of the Root Cause Medicine Podcast, Dr. Kate Kresge sits down with neurologist and bestselling author Dr. Dale Bredesen to challenge everything we think we know about brain aging. Dr. Bredesen shares why age-related cognitive decline is not just treatable but in many cases preventable—and even reversible. Drawing on decades of lab research and clinical success, he outlines the root causes of cognitive decline and introduces the listener to the "cognoscopy," a powerful tool for early detection. With practical, science-backed insights on inflammation, insulin resistance, environmental toxins, and the emerging brain microbiome, this is a masterclass in 21st-century brain health. You’ll here them discuss: - Why cognitive decline is often preventable—and sometimes reversible - The three key drivers of cognitive decline: inflammation, energy deficit, and toxicity - How to use the "cognoscopy" to catch signs of dementia early - The role of the brain’s microbiome and oral health in neurodegeneration - Why mold, metals, and mycotoxins are underestimated threats - New blood biomarkers like pTau217, GFAP, and NFL - Supplements that support brain health, including magnesium threonate and omega-3s - How to tailor treatment using functional lab testing and wearables - Stories of patient recovery—and what makes the difference Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

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• Healthy Gut, Happy Kids: Understanding Microbiome Health in Pediatrics with Dr. Elisa Song: Episode Rerun

  In this episode of The Root Cause Medicine Podcast, we’re joined by Dr. Elisa Song—pediatrician, integrative medicine expert, and author of Healthy Kids, Happy Kids. With a deep commitment to helping children thrive, Dr. Song shares how gut health forms the foundation of pediatric wellness and why holistic care is essential in addressing the chronic health challenges kids face today. We dive into how the microbiome shapes immunity, mood, and behavior, and why addressing nutrition, lifestyle, and environmental factors is crucial for long-term health. Dr. Song also breaks down five core pillars for nurturing a healthy gut in children and reveals the surprising ways added sugar and ultra-processed foods impact the developing brain. You’ll learn: - The role of gut health in preventing and managing childhood conditions - Five foundational habits to support your child’s microbiome - How sugar and processed foods disrupt children's brain and gut function - The link between gut health and mental wellness in kids - What lab tests can help assess and guide pediatric gut health interventions This episode is a must-listen for parents, caregivers, and healthcare providers who want to raise healthy, resilient children through informed, integrative strategies. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

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• How Evidence-Based Medicine Shapes Patient Care: Episode Rerun

  In this episode of The Root Cause Medicine Podcast, we’re joined by Dr. Allen Sussman—seasoned endocrinologist, educator, and author of Saving the Art of Medicine. With over three decades of experience, Dr. Sussman shares how evidence-based medicine can enhance patient care when it's combined with empathy, open-mindedness, and critical thinking. We explore how research can be misinterpreted, the value of integrating complementary approaches, and how true healing requires more than just following protocols—it requires understanding the person behind the diagnosis. You’ll learn: - How evidence-based medicine influences clinical decisions - The difference between statistical and clinical significance - The value of listening to patients and tailoring care - Why biases in studies must be considered when applying data - How alternative and integrative approaches may complement conventional care This episode is a must-listen for healthcare providers and curious patients alike who want to understand how medical evidence can be both scientific and compassionate. Order tests through Rupa Health, the BEST place to order functional medicine lab tests from 30+ labs - https://www.rupahealth.com/reference-guide

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• Dr. Carrie Jones Launches “Hello, Hormones”: A New Era in Women’s Health

  In this heartfelt farewell episode of The Root Cause Medicine Podcast, Dr. Kate Kresge and Dr. Carrie Jones sit down to share a major announcement: Dr. Carrie is stepping down as co-host to launch her own podcast, Hello, Hormones. This episode is full of reflection, laughter, and excitement as Dr. Carrie shares why now is the time to follow her calling to educate, empower, and entertain through hormone-focused conversations. With a book coming in 2026, thousands of hormone tests analyzed, and decades of clinical and teaching experience, Dr. Carrie is ready to deliver education that’s practical, hilarious, and deeply needed. You’ll hear them discuss: - Why Carrie is pivoting to launch Hello, Hormones - The vision for her new podcast: education, sass, and science - How misinformation around hormones (and cancer) persists - What women need to know about perimenopause, fertility, and metabolic health - Her certifications and clinical experience across naturopathic endocrinology - Her skincare, castor oil, and longevity tips (because glow matters too!) - The myth she wants to bust (hint: it’s about hormone fearmongering) - Why “you’ve always had the power” is her guiding truth

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