ASGCT Podcast Network

Dr. Anastasia Khvorova of UMass Chan Medical School joins The Issue Podcast to discuss the next frontier of siRNA therapeutics and delivery beyond the liver. During her discussion with co-hosts Sanjay D'Souza, PhD, and Jason West, PhD, she covers the kidney clearance barrier, local versus systemic delivery, how RNAi and gene editing complement each other, and where she expects the field to go over the next several years.
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We are excited to announce that Dr. Paloma Giangrande has committed to a second term as Editor-in-Chief of Molecular Therapy Nucleic Acids (MTNA). In this episode, Dr. Marcin Kortylewski, the Oligonucleotides: Therapies and Applications section editor of MTNA, interviews Paloma about her journey into science and RNA biology, her perspectives on therapeutic development, her initiatives during her first term as Editor-in-Chief, and her vision for MTNA in the next five years.
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In this episode of Scientists, Unedited, Luigi Naldini, PhD, Professor of Cell and Tissue Biology and of Gene and Cell Therapy at the San Raffaele University School of Medicine and Scientific Director of the San Raffaele Telethon Institute for Gene Therapy, joins host Eirini Vamva, PhD, for a discussion on his story. Dr. Naldini, a pioneer of lentiviral vectors, reflects on the unexpected path that led him to gene therapy and helped turn a bold scientific idea into a clinical reality. He discusses the risks, setbacks, collaborations, and family support that shaped his career, as well as the future of gene therapy and why meaningful scientific progress requires persistence, teamwork, and time.
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In this episode of The Issue, CEO of Life Biosciences Jerry McLaughlin joins hosts Sanjay D’Souza, PhD and Jason West, PhD for a discussion on how epigenetic reprogramming could restore function in aging and injured cells. He explains the science behind ER-100, an investigational gene therapy now in a Phase 1 trial for optic neuropathies, and explores the broader promise of targeting age-related diseases to help improve quality of life.
Music: ‘Bright New Morning’ by Steven O’Brien – released under CC-BY 4.0. https://www.steven-obrien.net/
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This episode, hosted by Daniel Stone, Associate Editor-in-Chief of Molecular Therapy Advances, focuses on the article, Normothermic perfusion of human livers for profiling lentiviral vector pharmacokinetics and transduction. Listen as Robert Carlisle and Brannon Nicholls from the University of Oxford discuss their approach to studying lentiviral vector transduction and pharmacokinetics in the human liver ex vivo.
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