Heart Doc VIP with Dr. Joel Kahn

Dr. Joel Kahn dives into a groundbreaking Phase 1 trial of Verve 102, a one-time intravenous gene-editing treatment that silences the PCSK9 gene to produce lasting LDL cholesterol reduction. Among 35 participants, the high-dose group saw LDL drop by 62% with mostly mild side effects — promising results, though Phase 2 and 3 trials and 15 years of follow-up still lie ahead.

Also covered: updated colorectal cancer screening guidelines now starting at age 45, healthy lifestyle habits cutting mortality risk in cancer survivors by one-third, real-world weight regain data after stopping GLP-1 medications, why your B12 "normal" range may be too low, a blood test that may predict Alzheimer's years in advance, and a longevity preparedness tool from MIT AgeLab.

Sponsored by Igennus — visit igennus.com/drkahn for 20% off.

In this episode of HeartDoc VIP, Dr. Joel Kahn breaks down the newly released — but not yet fully published — results from the highly anticipated Triumph-1 study on retatrutide, an investigational weight loss medication that's already generating major buzz in the cardiometabolic world.
The reported weight loss results at 80 and 104 weeks are remarkable, with side effects appearing consistent with other medications in this class, including semaglutide and tirzepatide. Dr. Kahn discusses what's known so far, what questions still remain, and why the full peer-reviewed publication is so important before drawing final conclusions on risks and benefits. FDA approval may not be far away.
Other topics in this packed episode include the troubling rise in fatal heart attacks among younger adults, a modified Mediterranean diet linked to lower diabetes risk, the connection between food preservatives and heart disease, atrial fibrillation in athletes, nitric oxide's role in brain health, fatty liver disease and cardiovascular risk, and how the American Heart Association's Life's Essential 8 score may predict diabetes risk in women.
Thanks to Igennus for sponsoring this episode. Visit their site and use promo code DRKAHN to save on high-quality supplements.

This week, Dr. Kahn discusses Bryan Johnson's efforts to reverse his "biological age" and the 41 lessons he has shared along the way. These are valuable insights that Dr. Kahn largely endorses.
Other topics include the sit-to-stand test; how PCOS can become PMOS; therapies for Peyronie's disease and PSA testing; plant-based diets and aging; plant-based diets during pregnancy; pregnancy complications; and the cardiac health of offspring. 
A big thanks to Igennus for supporting the podcast. Use discount code DrKahn to save on the BeKind line of plant-based nutritional products.

This week, Joel Kahn, MD, dives into fascinating new research on aged garlic extract and its potential role in healthy aging, muscle function, and cardiovascular wellness. He reviews a recent study showing how aged garlic extract improved muscle and aging markers in mice while also activating the NAMPT pathway in humans, which may help boost NAD+ production.
Dr. Kahn also breaks down several newer studies highlighting the cardiovascular benefits of aged garlic extract, a supplement he's used at the Kahn Center for more than a decade. He discusses the specific Kyolic formula available here: Kyolic Aged Garlic Extract
Additional topics include dietary nitrates from greens and nitric oxide production, the Mediterranean diet and longevity, high-intensity interval training and heart health, visual acuity and lifespan, plant-based diets and breast cancer outcomes, and the connection between poor sleep and survival rates. 
This episode is brought to you by VINIA and their line of heart-supporting products.

This week, Dr. Kahn discusses his long-standing interest in the amino acid glycine and its potential health benefits. Sleep is a key focus, highlighted by a new report on the widespread difficulty adults face in getting a full night's rest. Glycine may also offer favorable cardiovascular support.
Additional topics include coffee and aging, methamphetamines and heart attacks, Lipoprotein(a) and cardiovascular risk, yoga and overall health, a tribute to Eugene Braunwald, MD, TMAO and atherosclerosis, and a new study on the benefits of adopting heart-healthy habits early in life. 
Thanks to the Fresh Pressed Olive Oil Club and the special discount offer at getfreshdrkahn.com