LEVITY

• #19 What are the chances humanity will survive this century? | Anders Sandberg

  We have an other amazing guest for this episode: Anders Sandberg is a visionary philosopher, futurist, and transhumanist thinker whose work pushes the boundaries of human potential and the future of intelligence. As a senior research fellow at Oxford University’s Future of Humanity Institute until its closing in 2024 Sandberg explores everything from cognitive enhancement and artificial intelligence to existential risks and space colonization. With a background in computational neuroscience, he bridges science and philosophy to tackle some of the most profound questions of our time: How can we expand our cognitive capacities? What are the ethical implications of radical life extension? Could we one day transcend biological limitations entirely? Known for his sharp intellect, playful curiosity, and fearless speculation, Sandberg challenges conventional wisdom, inviting us to imagine—and shape—a future where humanity thrives beyond its current constraints.00:00 introduction04:18 exersise & David Sinclair06:10 Will we survive the century?18:18 Who can we trust? Knowledge and humility23:17 Nuclear armaggedon39:51 Technology as a double-edged sword44:30 Sandberg origin story56:54 Computational neuroscience01:00:30 Personal identity and neural simulation01:05:24 Personal identity and reasons to want to continue living01:09:39 The psychology of behind different philosophical intutions and judgments01:17:48 Is death bad for Anders Sandberg?01:25:00 Altruism and individual rights01:31:29 Elon Musk says we must die for progress01:35:10 Artificial Intelligence01:55:08 AI civilization01:02:07 Cryonics02:04:00 Book recommendations Hosted on Acast. See acast.com/privacy for more information.

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• #18 Aubrey de Grey | The Big 2025 Interview

  In this in-depth conversation, Dr. Aubrey de Grey discusses his Robust Mouse Rejuvenation (RMR) studies at the LEV Foundation and why he believes we're close to achieving the crucial RMR milestone within just three years - a breakthrough that could transform aging research forever.You'll also hear about:His predictions for reaching Longevity Escape Velocity by the late 2030sWhat he would change about Bryan Johnson's longevity algorithmHow reaching RMR could trigger a global "war on aging"Why AI won't solve aging without proper experimental dataHow Demis Hassabis is the smartest person Aubrey's ever metHis involvement in designing the XPRIZE Healthspan competitionHis rebuttal to Mark Hamalainen's "replacement strategy" approachThe divide-and-conquer approach to aging and why it's superior🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/-- CHAPTERS --00:00 Introduction and Welcome03:15 The Background to LEV Foundation and the Robust Mouse Rejuvenation Studies12:05 The Robust Mouse Rejuvenation Studies18:10 Latest Results from the Mouse Rejuvenation Experiments25:42 Reaching RMR soon and LEV in 12-15 years33:47 Healthspanners in public - lifespanners in private?37:03 The Replacement Strategy Debate with Mark Hamalainen45:40 The Very, Very Difficult Challenge of Gradually Replacing the Brain54:46 Advanced bioengineering57:34 The Debate with Peter Fedichev01:11:57 Understanding Aging from an Evolutionary Perspective01:17:05 Artificial Intelligence and Longevity Research01:26:42 Is believing in AI hopium?1:28:27 Aubrey’s Involvement in the XPRIZE Healthspan Competition1:38:56 Special Economic Zones and Regulatory Challenges1:47:27 What Aubrey would do with Bryan Johnson’s algorithm1:50:49 What Excites Aubrey Most About the Future1:51:57 Book Recommendations and Closing Thoughts Hosted on Acast. See acast.com/privacy for more information.

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• #17 How the $101M XPRIZE will reverse aging by 20 years | Jamie Justice

  Jamie Justice takes us inside the $101M XPRIZE Healthspan competition - one of the world's largest efforts to develop therapeutics that could reverse aging.As Executive Vice President of XPRIZE Healthspan, Jamie reveals how teams must demonstrate they can restore muscle, cognitive, and immune function in older adults within just one year. The stakes? $81M for achieving a 20-year reversal of aging markers, with $71M and $61M prizes for lesser but still remarkable achievements.Jamie shares her fascinating journey from studying crickets' lifespans in elementary school to leading groundbreaking aging research, including work on the TAME trial with metformin. She explains why they chose these specific biological systems to measure, how they'll determine success, and what kinds of interventions teams are exploring - from repurposed drugs to gene therapies.We discuss:* Why Peter Diamandis pushed for more ambitious goals* How over 550 teams from 55 countries are approaching the challenge EDIT: Since we recorded this in late 2024 they've now reached over 600 teams.* The role of biomarkers in measuring aging* Why they chose to measure actual restoration rather than just preventing decline* The challenges and opportunities in aging clinical trials* Her vision for an integrated, multi-generational society that values aging populations🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/CHAPTERS:00:00 Introduction03:00 background21:30 XPRIZE sculpted by experience25:20 Collaborating with the entrant teams29:00 Why muscle, mind and immune functions as targets36:30 What if no one wins in 7-years?41:05 Investors attracted45:01 Does this give us increased longevity?51:05 What kind of approaches have been entered?01:00:30 AI01:09:20 Composit end-points01:13:10 TAME trial stuck because ...01:19:10 Biomarkers of aging01:26:50 AI and Biomarkers01:29:02 The longbio track (be lucky)01:36:20 Optimism about what?01:41:00 3 book you have to read Hosted on Acast. See acast.com/privacy for more information.

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• #16 Critical health signals your doctor is overlooking | David Luu

  A pediatric cardiac surgeon turned longevity pioneer, Dr. David Luu shares his journey from humanitarian medical missions to building a global network of physicians focused on prevention. Learn about critical health markers your doctor might be missing, how AI is transforming healthcare, the truth about longevity interventions, and why the future belongs to prevention rather than treatment. Plus, discover the vital link between community, lifestyle, and longevity, and why creating modern "blue zones" might be key to living longer, healthier lives.🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/CHAPTERS00:00 Introduction 02:33 A Family Legacy in Medicine 10:41 From Heart Surgeon to Tech Innovator with JuiSci and Hearty 13:47 Building AI-Powered Medical Platforms 21:33 The Heart Fund: Surgery for Those in Need 35:06 The Role of AI in Healthcare 45:22 Creating Longevity Docs Community 01:07:13 Hidden Cardiovascular Risk Factors 01:10:38 The Lp(a) Test Everyone Should Know About01:18:50 Why Call it ”Longevity Docs” When We Have No Approved Aging Interventions? 01:28:14 Different Levels of Longevity Interventions 01:38:42 Risk vs. Reward in Preventive Medicine 01:43:30 Building Modern Blue Zones 01:47:11 The Future of Medicine 01:52:07 Connecting with David Hosted on Acast. See acast.com/privacy for more information.

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• #15 Fifty years of fighting death | James Strole

  🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/Meet one of the true legends of the longevity space, James Strole, the visionary founder of RAADfest who embodies relentless optimism and dedication to advancing the frontiers of longevity and human potential. His passion for creating a world where individuals can live longer, healthier lives shines through in every aspect of RAADfest, inspiring countless people to embrace the possibilities of radical life extension.We will learn about RAADfest and the history of the longevity movement. We will also explore Strole's philosophy of immortality.- CHAPTERS --00:00 introduction to James Strole04:20 RAADfest is the largest longevity event in the world11:50 personal awakening and the early days of the longevity movement22:00 longevity as a counter-culture23:00 death-program vs superlongevity26:30 1960s spreading the word and rebirthing31.00 people unlimited and science of superlongevity33:00 a holistic approach science of mind-set34:00 alternative medicine not always taken seriously37:40 the immortality mindset38:50 aged by culture44:20 optimism vs pessimism46:10 optimism about longevity science?58:50 death-program runs deep01:03:30 Ray Kurzweil's optimistic prognosis01:11:00 social consequences of longevity01:12:30 cryonics is an ambulance to the future01:15:05 imaginary mortality01:18:18 immortality via children01:19:19 is superlongevity egoistic?01:23:10 handle the loss of near and dear as an immortalist01:37:50 advice on health and where to be in contact with People Unlimited and James Strole Hosted on Acast. See acast.com/privacy for more information.

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