#481 The Anti-Aging Pill Chinese Scientists Are Developing - Aiming for 120+ Lifespans - Yip Tszho
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandYip (Zico) Tszho is the Chief Executive of Lonvi Biosciences, a longevity-drug start-up, in Shenzhen, China. They're developing pharmaceuticals for extending human lifespan. We discuss their first senolytic called PCC1. Timestamps:00:00 Intro00:15 Articles about a pill making people live to 15002:50 What is PCC1 and how is it made07:10 How much can targeting senescence extend lifespan12:25 Bon Charge sponsorship13:15 Dose of PCC1 for senolytic and senomorphic effects18:30 PCC1 extending lifespan in mice by 9.4%23:20 Absorption rate of PCC1 and other senolytics27:10 Senolytics for young vs old age31:10 Human study on PCC134:40 What’s the optimal dose for senolytics38:05 Biomarkers of cell senescence40:10 Senolytic benefits on skin and retina46:35 What’s going on in Chinese longevity science52:10 Future direction of PCC1PCC1 studies: https://lonvibio.com/pages/science
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#480 The Science of Saunas: How Heat Boosts Fitness & Longevity - Brady Holmer MSc
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandBrady Holmer is a science writer and researcher with a Master's degree in Human Performance from the University of FloridaTimestamps:00:00 Intro00:40 Why heat acclimation has performance benefits08:10 How to train heat acclimation12:40 Bon Charge sponsorship13:30 Benefits of the sauna for fitness18:25 Saunas and injury recovery22:30 Cold exposure and exercise performance26:45 Cooling down during and before exercise31:40 How often to train heat acclimation and sauna37:05 Sauna and HRV38:10 How long to stay in the sauna41:15 Electrolytes and dehydration acclimation46:25 Differences between men and women in heat acclimation47:00 Does heat acclimation have longevity benefits49:05 Does cold exposure have longevity benefits54:30 Which research should be done more on heat acclimationFirst podcast with Brady about VO2 max: https://youtu.be/xLDaFhN6h8IBrady Holmer Twitter: https://x.com/B_HolmerBrady Holmer website: https://www.bradyholmer.com/Start rewinding your biological clock: https://www.siimland.co/course
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#479 Longevity Testing 101: What Really Matters (with Siim Land and Dr. Joy Kong)
Join our upcoming retreat in January 2026: https://www.siimland.co/retreat Timestamps:Introduction (00:00)Discussion on longevity clinics and testing (01:52)Essential health tests and biomarkers (05:45)Improving VO2 Max and cardiovascular health (11:28)Blood tests and metabolic health (16:42)Hormone tests and longevity (21:35)Microbiome tests and toxicity (26:55)Microplastics and environmental toxicity (32:14)Food sensitivity testing (39:01)NAD testing and energy metabolism (41:50)Comprehensive health retreat (49:29)Dr. Joy Kong Youtube channel: https://www.siimland.co/retreat
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#478 Mitochondria Scientist: The Only Proven Way to Extend Human Lifespan - Dr Mark Tarnopolsky
Dr. Mark Tarnopolsky is a Professor and Division Head of Neuromuscular and Neurometabolic Disorders in the Department of Pediatrics at McMaster University. He completed a PhD in Cell Biology and Metabolism in 2001.Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:25 What are mitochondria03:55 Mitochondria in aging and longevity06:00 Oxidative stress, inflammation, and longevity09:30 Antioxidants and benefits of exercise12:40 Bon Charge sponsorship13:30 Who should take antioxidants21:30 Mark’s antioxidant cocktail study24:30 Why is exercise the best thing for your mitochondria30:35 How endurance training shapes the mitochondria35:10 High intensity interval training36:50 Role of mitochondria in muscle loss42:00 Nutrition for mitochondrial health46:50 Supplements for mitochondrial health53:35 Stimulating mitophagy Dr Mark Tarnopolsky research page: https://scholar.google.com/citations?user=4jhi_KkAAAAJ&hl=en
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#477 The Science of Longevity Genes: What We’ve Learned from Centenarians - Dr Tyler Panzner
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimlandTimestamps:00:00 Intro00:48 The genetics of a 117-year-old woman08:16 Resilience, immunity and longevity14:33 Muscle building genetics19:33 FOXO3 and stress resilience24:53 FOXO3 gene editing32:08 Can telomere lengthening be harmful to some individuals38:58 IGF-1 and growth hormone and longevity50:08 Genetically short sleepers54:38 What you should know about your longevity genesFirst podcast with Tyler about genetics and supplements: https://youtu.be/9GLbTEYewUsTyler Panzner channel: https://www.youtube.com/@drtylerpanzner
Siim Land is an author, speaker, and consultant. He talks about optimizing health, performance, and longevity with different techniques and biohacking.
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