Siim Land Podcast

Siim Land returns as the current leader of the Longevity World Cup, to break down supplements, biomarkers, VO2 max, inflammation, sleep, and the difference between building health versus simply maintaining it.
Watch on YouTube: https://www.youtube.com/watch?v=ogy7l0nka-Y

Dr. Alexis Ortega is board-certified in longevity, regenerative and aesthetic medicine. He has a clinic Ad Astra in Barcelona, Spain.
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland
Timestamps:
00:00 Intro
00:55 How to counteract age-related loss of facial harmony aside from just wrinkles
12:30 Does growth hormone change the face
18:10 Bon Charge sponsorship
19:17 What's the minimum effective dose of at-home skincare — the three things that actually move the needle?
21:28 Retinoids
24:05 Skin barrier support
27:00 Effect of sun exposure on extrinsic skin aging
31:02 Best evidence-based sunscreen ingredients
34:34 List of best sunscreen ingredients
36:00 Worst sunscreen ingredients
37:45 Daily sunscreen vs using the UV index as a guide
39:43 Do people overuse skincare products
42:33 Castor oil, beef tallow and egg yolks for skin
49:08 Are natural sunscreens effective
49:59 If someone had unlimited money today, what are the most promising rejuvenation interventions actually available?
51:08 What diagnostics Alexis would do with an unlimited budget
54:30 Rejuvenation therapies Alexis would do
55:18 Alexis approach to peptides
56:00 Intravenous senolytics
56:20 NAD injections
57:14 What you can do now to practically extend lifespan
59:40 Intravenous exosomes
01:00:25 Therapeutic plasma exchange
01:03:06 Stem cell therapy
01:05:30 Gene therapies
01:07:48 What biomarkers matter most for predicting long-term health
Alexis Ortega MD Instagram: https://www.instagram.com/alexis_ortega_md/

Dr. Kevin Perez is a computational biologist working at the cutting edge of aging science and drug discovery. His work focuses on aging research, drug repurposing, and integrating complex multi-omics data to better understand how we can extend healthspan.
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland
Timestamps:
00:00 Intro
00:47 Kevin’s study about pharmaceuticals that are associated with reduced mortality
10:17 Which class of drugs had reduced mortality
13:07 Bon Charge sponsorship
14:12 How Kevin researches longevity molecules
16:37 Estrogen’s longevity effects
17:37 How Kevin started researching dog aging
25:32 Chemical reprogramming
29:32 Kevin’s understanding of what causes aging
34:52 Metformin vs SGLT2 inhibitors
38:37 Erectile dysfunction drugs
43:02 Over the counter supplements with longevity effects
45:52 Biological age clocks
50:02 What Kevin thinks is the best biomarker of aging
54:32 Composite biological age vs combination of multiple markers
59:32 Kevin’s new study plans
01:02:52 What Kevin wishes he adopted sooner
Start rewinding your biological clock: https://www.siimland.co/course
P.S. This is not professional medical advice and should not be taken as such. The creator of this video is not held accountable for your health. Consult your doctor first.

Join our LONGEVITY Community: https://www.skool.com/longevity-society
Timestamps:
00:00 Intro
00:37 Why Brad crowd funded a rapamycin trial
03:22 What Brad’s rapamycin trial found
12:57 Why rapamycin blunted the effects
17:17 Rapamycin effects on grip strength
19:57 Rapamycin and immune effects
21:47 Effects on biomarkers
25:22 Brad’s thoughts on rapamycin moving forward
31:52 Metformin exercise effects
32:52 Other medicines with longevity potential
36:37 Medicines that move the needle the most for people
45:17 Will Brad do another study
48:27 Brad on GLP-1s
Dr Brad Stanfield is a family medicine doctor in New Zealand: https://www.youtube.com/@DrBradStanfield
Bloodwork for longevity panel discussion: https://youtu.be/7QONBQCpRJ0
My 2026 longevity routine: https://youtu.be/OceysodInIo
Start rewinding your biological clock: https://www.siimland.co/course

Dr. Greg Potter has a PhD from the University of Leeds in sleep, nutrition, and metabolism.
Check out Bon Charge wellness products (Code SIIM for 15% discount): https://boncharge.com/siimland
Timestamps:
00:00 Intro
00:45 Catchup
02:05 Are circadian rhythms nature or nurture
09:55 What’s ideal timing of sunlight exposure for circadian anchoring
15:25 Bon Charge sponsorship
20:30 Does creatine increase DHEA or DHT levels
25:50 Does creatine reduce sleep quality
33:25 Greg’s new podcast
36:15 Is more REM sleep better
42:05 How to optimize REM sleep
44:25 What % of different sleep cycles should we get (light, deep, REM)
46:10 Is food processing good or bad
52:45 Incline bed therapy
55:20 Is it bad to use sleep herbs
58:45 Does melatonin supplementation stop natural production
01:01:15 What to do if you wake up at night and can’t fall back asleep
Greg Potter YouTube Channel: https://www.youtube.com/@gregpotterphd