Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould mycotoxins and Small Intestinal Bacterial Overgrowth (SIBO) — and why so many people with chronic digestive symptoms may be missing the true root cause of their gut dysfunction.
If you’ve been struggling with bloating, reflux, constipation, diarrhea, histamine intolerance, food sensitivities, nausea, fatigue, or recurring SIBO that never fully resolves, this episode explains how mould exposure may be contributing to ongoing nervous system and digestive dysfunction.
Joanne breaks down the mechanisms behind mould-related gut issues, including how mycotoxins impact the vagus nerve, gut motility, stomach acid production, bile flow, pancreatic enzymes, inflammation, and the migrating motor complex. She also discusses why chronic SIBO cases are often difficult to treat when mould toxicity is not properly addressed.
In this episode, you’ll learn:
Why mould illness and SIBO commonly occur together
How poor vagal tone affects digestion and bacterial overgrowth
The connection between mould, histamine intolerance, and mast cell activation
Why low stomach acid and sluggish bile flow can worsen gut symptoms
How chronic inflammation disrupts gut motility and digestive function
Why antibiotics and herbal antimicrobials may not fully resolve SIBO
The importance of mould testing in chronic gut health conditions
#SIBO #MouldIllness #HistamineIntolerance #GutHealth #Mycotoxins #MCAS #FunctionalMedicine #DigestiveHealth #MoldToxicity #VagusNerve
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

What if your histamine symptoms aren’t just about food? In this episode of the The Histamine Well Podcast, Joanne explores the overlooked connection between bile flow, histamine intolerance, SIBO, estrogen dominance, mold exposure, oxalates, methylation, and chronic inflammation.
Bile plays a critical role in digestion, detoxification, hormone clearance, and microbial balance in the gut. When bile flow becomes sluggish, it can contribute to bacterial overgrowth, poor fat digestion, impaired estrogen detoxification, oxalate accumulation, and worsening histamine symptoms.
In this episode, Joanne explains:
How poor bile flow contributes to histamine intolerance
Why mold toxicity and mycotoxins affect the liver and gallbladder
The vicious cycle between SIBO and bile dysfunction
How estrogen dominance impacts bile flow and histamine
Why oxalates can worsen inflammation and histamine symptoms
The role of methylation and phosphatidylcholine in healthy bile production
How vagus nerve dysfunction affects digestion and bile release
Common signs and symptoms of poor bile flow
This episode is essential listening for anyone struggling with histamine intolerance, MCAS, gut health issues, bloating, hormone imbalances, mold illness, chronic inflammation, food sensitivities, or unexplained digestive symptoms.
🎧 Subscribe to The Histamine Well Podcast for evidence-based conversations on histamine intolerance, methylation, SIBO, mold illness, women’s hormones, and functional medicine.
#HistamineIntolerance #SIBO #GutHealth #MoldIllness #EstrogenDominance #Oxalates #Methylation #FunctionalMedicine #BileFlow
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Can methylated B vitamins make your symptoms worse instead of better? In this episode of The Histamine Well Podcast, Joanne explains the connection between high homocysteine, histamine intolerance, methylation, and why some people react poorly to methylated nutrients.
High homocysteine is associated with cardiovascular disease, cognitive decline, inflammation, and neurological health concerns — yet lowering it isn’t always simple. Many people experience headaches, anxiety, insomnia, digestive issues, skin flare-ups, or worsening histamine symptoms when taking methylfolate or methyl B12.
Joanne breaks down the methylation cycle in simple terms, explains the role of histamine in nutrient tolerance, and explores how genetics such as the MTHFR gene mutation and COMT enzyme activity may influence how your body responds to methylated supplements.
In this episode, you’ll learn:
 • What high homocysteine means and why it matters
 • The connection between homocysteine and methylation
 • Why methylated B vitamins can trigger symptoms
 • Histamine intolerance and supplement sensitivity
 • The role of MTHFR, COMT, and methylation pathways
 • Overmethylation vs undermethylation explained
 • Practical clinical insights for improving tolerance to methyl nutrients
Whether you're a practitioner, student, or navigating your own health journey, this episode offers practical education on histamine, methylation, gut health, and root-cause healing.
Subscribe to The Histamine Well Podcast for expert discussions on histamine intolerance, women’s hormones, functional medicine, gut health, methylation, and integrative wellness.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

Can you take Calcium-D-Glucarate while on HRT estrogen during menopause? In this short Q&A episode of The Histamine Well Podcast, Joanne explores the relationship between estrogen detoxification, hormone replacement therapy (HRT), menopause, gut health, and histamine-related symptoms.
Many women are advised to take supplements that support estrogen detox, but is this always the right approach when using bioidentical hormones or estrogen therapy? Joanne explains why Calcium-D-Glucarate may not be beneficial for menopausal women on HRT, how estrogen balance works during menopause, and why understanding your hormone dose matters for symptom relief and long-term wellbeing.
This episode also covers:
 The role of estrogen during menopause and HRT 
 Why over-detoxifying estrogen may worsen symptoms 
 The connection between beta-glucuronidase, the estrobolome, and gut microbiome health 
 Histamine intolerance, hormone imbalance, and menopause symptoms 
 Natural considerations for estrogen metabolism and hormone support 
 Why gut health may be more important than estrogen detox supplements 
If you're navigating menopause, hormone replacement therapy, estrogen dominance symptoms, histamine intolerance, or gut-related hormone imbalance, this episode offers practical clarity backed by clinical naturopathic insight. 
Subscribe to The Histamine Well Podcast for expert conversations on histamine intolerance, methylation, gut health, hormones, mold illness, MCAS, menopause, and functional medicine approaches to healing.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well, Joanne shares a powerful clinical case study exploring the connection between SIBO (Small Intestinal Bacterial Overgrowth), histamine intolerance, hormonal imbalance, estrogen dominance, gut health, bloating, acne, fatigue, and PMS symptoms.
This episode follows the journey of a 37-year-old woman who experienced rapid body changes over two years — including unexplained weight gain, chronic bloating, severe PMS, hormonal acne, headaches, fluid retention, breast tenderness, digestive discomfort, and low energy. Through functional testing and a naturopathic treatment approach, Joanne uncovers how gut dysfunction, histamine overload, and hormone imbalance can work together to drive chronic symptoms.
You’ll discover how SIBO contributes to nutrient malabsorption, inflammation, estrogen dominance, histamine intolerance, and digestive dysfunction, along with why symptoms such as bloating, fatigue, skin issues, and menstrual changes are often connected.
In this episode, Joanne discusses:
The link between SIBO, histamine intolerance, and hormonal imbalance
Why bloating, PMS, headaches, and acne may stem from gut dysfunction
The difference between hydrogen and methane SIBO
How nutrient deficiencies affect hormones, mood, and energy
Why is bowel motility essential for successful SIBO treatment
The role of biofilms in persistent gut symptoms
Functional medicine strategies for improving gut and hormone health
Whether you are a practitioner, student, or someone navigating digestive and hormone-related symptoms, this episode offers practical insight into the deep connection between gut health, histamine, hormones, and systemic inflammation.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
 🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!