Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

In this episode of The Histamine Well Podcast, Joanne explains how Helicobacter pylori (H. pylori) can quietly drive histamine intolerance, SIBO, and hormone imbalance — even without classic ulcer or reflux symptoms.
H. pylori produces urease, converting urea into ammonia and lowering stomach acid. This reduction in hydrochloric acid can impair protein digestion, weaken pathogen control, and disrupt digestive signaling — creating the perfect environment for small intestinal bacterial overgrowth (SIBO) and rising histamine levels. The result can be a “histamine storm” of inflammation and systemic symptoms.
Common signs may include:
Food reactions
Bloating and gas
Hives or eczema
Anxiety and insomnia
Headaches
PMS, estrogen dominance, and perimenopause flares
Joanne also discusses the pros and cons of triple therapy (antibiotics plus proton pump inhibitors), post-treatment gut repair, and natural strategies such as sulforaphane and gut-healing support.
If your histamine symptoms persist despite dietary changes, this episode explores a deeper gut–histamine–hormone connection that may be driving the root cause.
What You’ll Learn:
How H. pylori disrupts stomach acid and digestion
The link between low stomach acid, SIBO, and histamine intolerance
Why mast cell activation increases systemic symptoms
How histamine impacts estrogen and perimenopause
Treatment considerations and natural support options
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this short Clarity Session Q&A, Joanne explains the key differences between common magnesium forms and how to choose the right one for symptoms like anxiety, sleep issues, constipation, migraines, fatigue, muscle pain, or brain fog. Learn when each type may help—and when to avoid certain forms if you’re sensitive. 
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of The Histamine Well Podcast, Joanne explores how candida, yeast, and fungal overgrowth can worsen histamine intolerance and trigger ongoing mast cell symptoms.
She explains how fungal-driven gut inflammation increases histamine production by activating mast cells, upregulating histidine decarboxylase (HDC), and reducing DAO enzyme activity — making it harder for the body to break histamine down.
You’ll learn why antifungals alone often fail, how gut “terrain” factors like low stomach acid, poor bile flow, digestive enzyme insufficiency, microbiome imbalance, mold exposure, and chronic stress allow fungal overgrowth to persist, and how SIBO and SIFO are connected through small intestinal pH imbalance.
If you struggle with histamine intolerance, sugar cravings, brain fog after carbs, bloating, or recurrent candida, this episode explains the deeper root causes — and why nervous system regulation is essential for long-term healing.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this short Clarity Session Q&A bonus episode of The Histamine Well Podcast, Joanne explains what antihistamines actually do, why symptoms often return when you stop them, and the common root causes behind histamine issues. Learn the difference between symptom suppression and true regulation of the gut, detox pathways, and nervous system. 
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!

In this episode of the Histamine Well Podcast, Joanne speaks with Rachel Scott, who developed severe food intolerances, intense histamine reactions, and unexplained chronic symptoms following mold exposure.
After years of misdiagnosis and treatments that failed to address the root cause, Rachel’s health continued to deteriorate — until a simpler, more balanced approach was introduced. Rachel shares how targeted support using sulforaphane, digestive enzymes, and Epsom salt baths helped stabilize her system and gradually restore tolerance to food.
Joanne explains the biochemical drivers behind mold-related illness, including sulfur metabolism, detoxification pathways, and nervous system load, and why aggressive protocols, heavy supplementation, and herbal overuse can often worsen symptoms in sensitive individuals.
This conversation highlights the importance of gentle, well-timed interventions, practitioner guidance, and understanding the body’s capacity before pushing detoxification.
Topics covered include:
Severe food reactions and histamine intolerance
Mold exposure and chronic illness
Sulforaphane and detoxification support
Sulfur metabolism and nervous system balance
Why “less is more” in complex healing cases
Show Notes: 
🌐 Official Program Links
1. The Gupta Program – Brain Retraining
This is the main site for the limbic retraining and neuroplasticity program designed to help calm the nervous system and support recovery from chronic and sensitivity-related conditions.
2. Irene Lyon – Somatic & Nervous System Work
This is the official site for Irene Lyon, a nervous system expert who provides somatic-based exercises and education to help regulate the nervous system body-mind connection.
3. Cell‑Logic – G.E.M.M. Protocol for Patients
This page explains the G.E.M.M. Protocol (Gut Ecology & Metabolic Modulation) — an approach focused on restoring cellular health and gut-immune balance.
✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.
🧪 Curious about your methylation status? Try our at-home Methylation Test! In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off.
🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course starting early 2026!
📆 Work with us 1:1! Book a consultation and take your first step to real healing.

🎤 Have a topic suggestion? Submit it here!