Medscape InDiscussion: Cardiorenal Metabolic Syndrome

• Bridging the Care Gap in Cardiorenal Metabolic Care

  Join Drs Nihar Desai, Ankeet Bhatt, and Tariq Ahmad as they discuss implementation science and the management of cardiorenal metabolic syndrome. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999847. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association https://pubmed.ncbi.nlm.nih.gov/37807924/ A Global Health Tidal Wave? Cardiorenal Metabolic Syndrome https://www.medscape.com/viewarticle/999839 Social Determinants of Health in Cardiorenal Conditions https://www.medscape.com/viewarticle/999840 Implementation Science to Achieve Equity in Heart Failure Care: A Scientific Statement From the American Heart Association https://pubmed.ncbi.nlm.nih.gov/38567497/ Epidemiology of Chronic Kidney Disease: An Update 2022 https://pubmed.ncbi.nlm.nih.gov/35529086/ Inpatient Use of Guideline-Directed Medical Therapy During Heart Failure Hospitalizations Among Community-Based Health Systems https://pubmed.ncbi.nlm.nih.gov/39269395/ The Gap to Fill: Rationale for Rapid Initiation and Optimal Titration of Comprehensive Disease-modifying Medical Therapy for Heart Failure With Reduced Ejection Fraction https://pubmed.ncbi.nlm.nih.gov/34950508/ The Inflation Reduction Act and Patient Costs for Drugs to Treat Heart Failure https://pubmed.ncbi.nlm.nih.gov/39470641/ The Inflation Reduction Act: How Will Medicare Negotiating Drug Prices Impact Patients With Heart Disease? https://pubmed.ncbi.nlm.nih.gov/37097432/ Evaluating Digital Technologies for Implementation Science https://pubmed.ncbi.nlm.nih.gov/35995390/

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• How Do You Holistically Manage Triglycerides and HDL for Cardiorenal Metabolic Syndrome?

  Join Drs Nihar Desai and Pam Taub as they discuss the nuances involved in understanding and managing triglycerides and HDL for cardiorenal metabolic syndrome. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999846. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A State-of-the-Art Review https://pubmed.ncbi.nlm.nih.gov/38103820/ The Association Between Triglycerides and Incident Cardiovascular Disease: What Is "Optimal"? https://pubmed.ncbi.nlm.nih.gov/32571728/ Helsinki Heart Study: Primary-Prevention Trial With Gemfibrozil in Middle-Aged Men With Dyslipidemia. Safety of Treatment, Changes in Risk Factors, and Incidence of Coronary Heart Disease https://pubmed.ncbi.nlm.nih.gov/3313041/ Effects of Combination Lipid Therapy in Type 2 Diabetes Mellitus https://pubmed.ncbi.nlm.nih.gov/20228404/ Triglyceride Lowering With Pemafibrate to Reduce Cardiovascular Risk https://pubmed.ncbi.nlm.nih.gov/36342113/ Apolipoprotein B https://emedicine.medscape.com/article/2087335-overview Cardiovascular Risk Reduction With Icosapent Ethyl for Hypertriglyceridemia https://pubmed.ncbi.nlm.nih.gov/30415628/ Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/33190147/ Plozasiran, an RNA Interference Agent Targeting APOC3, for Mixed Hyperlipidemia https://pubmed.ncbi.nlm.nih.gov/38804517/ PCSK9 Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK448100/ 2021 ACC Expert Consensus Decision Pathway on the Management of ASCVD Risk Reduction in Patients With Persistent Hypertriglyceridemia: A Report of the American College of Cardiology Solution Set Oversight Committee https://pubmed.ncbi.nlm.nih.gov/34332805/ Apolipoprotein A-I Infusions and Cardiovascular Outcomes in Acute Myocardial Infarction According to Baseline LDL-Cholesterol Levels: The AEGIS-II Trial https://pubmed.ncbi.nlm.nih.gov/39221651/ Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association https://pubmed.ncbi.nlm.nih.gov/37807924/

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• The New Penicillin? Pharmacotherapy for Obesity

  Join Drs Nihar Desai and Neda Rasouli as they discuss the evolution of obesity treatment over the past two decades, including the latest novel therapies. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999845. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A State-of-the-Art Review https://pubmed.ncbi.nlm.nih.gov/38103820/ Obesity https://emedicine.medscape.com/article/123702-overview A Synopsis of the Evidence for the Science and Clinical Management of Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Scientific Statement From the American Heart Association https://pubmed.ncbi.nlm.nih.gov/37807920/ Obesity and Severe Obesity Prevalence in Adults: United States, August 2021–August 2023 https://www.cdc.gov/nchs/products/databriefs/db508.htm Physiology, Obesity Neurohormonal Appetite and Satiety Control https://www.ncbi.nlm.nih.gov/books/NBK555906/ Melanocortin-4 Receptor Complexity in Energy Homeostasis, Obesity and Drug Development Strategies https://pubmed.ncbi.nlm.nih.gov/34882941/ Bariatric Surgery https://emedicine.medscape.com/article/197081-overview The Effects of Bariatric Surgery on Cardiovascular Outcomes and Cardiovascular Mortality: A Systematic Review and Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/36909063/ Semaglutide and Cardiovascular Outcomes in Obesity Without Diabetes https://pubmed.ncbi.nlm.nih.gov/37952131/ Comparison of Tirzepatide and Dulaglutide on Major Adverse Cardiovascular Events in Participants With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease: SURPASS-CVOT Design and Baseline Characteristics https://pubmed.ncbi.nlm.nih.gov/37758044/ A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity (SURMOUNT-MMO) https://clinicaltrials.gov/study/NCT05556512 Effects of Semaglutide on Chronic Kidney Disease in Patients With Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/38785209/

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• Cardiorenal Metabolic Syndrome: LDL Cholesterol, Dyslipidemia, and Lipoprotein(a)

  Join Drs Nihar Desai and Seth Martin as they discuss low-density lipoprotein (LDL) cholesterol, dyslipidemia, and lipoprotein(a) for patients with cardiorenal metabolic syndrome. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999844. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources Benefit of Adding Ezetimibe to Statin Therapy on Cardiovascular Outcomes and Safety in Patients With Versus Without Diabetes Mellitus: Results From IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial) https://pubmed.ncbi.nlm.nih.gov/29263150/ Evolocumab and Clinical Outcomes in Patients With Cardiovascular Disease https://pubmed.ncbi.nlm.nih.gov/28304224/ Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients https://pubmed.ncbi.nlm.nih.gov/36876740/ Two Phase 3 Trials of Inclisiran in Patients With Elevated LDL Cholesterol https://pubmed.ncbi.nlm.nih.gov/32187462/ Study of Heart and Renal Protection (SHARP): Randomized Trial to Assess the Effects of Lowering Low-Density Lipoprotein Cholesterol Among 9438 Patients With Chronic Kidney Disease https://pubmed.ncbi.nlm.nih.gov/21095263/ Cardiovascular Risk Reduction With Icosapent Ethyl for Hypertriglyceridemia https://pubmed.ncbi.nlm.nih.gov/30415628/ Effect of Pelacarsen on Lipoprotein(a) Cholesterol and Corrected Low-Density Lipoprotein Cholesterol https://pubmed.ncbi.nlm.nih.gov/35300814/ Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease https://pubmed.ncbi.nlm.nih.gov/36342163/ Lipoprotein(a) in Atherosclerotic Cardiovascular Disease and Aortic Stenosis: A European Atherosclerosis Society Consensus Statement https://pubmed.ncbi.nlm.nih.gov/36036785/ A Focused Update to the 2019 NLA Scientific Statement on Use of Lipoprotein(a) in Clinical Practice https://pubmed.ncbi.nlm.nih.gov/38565461/

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• Cardiorenal Metabolic Syndrome: MRAs and Potassium Binders

  Drs Nihar Desai, Andrew J. Sauer, and Matthew A. Sparks discuss novel therapies in cardiorenal metabolic syndrome, focusing in on the MRAs and potassium binders. Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999843. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals. Resources The Kidney Failure Risk Equation: Evaluation of Novel Input Variables Including eGFR Estimated Using the CKD-EPI 2021 Equation in 59 Cohorts https://pubmed.ncbi.nlm.nih.gov/36857500/ Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association https://pubmed.ncbi.nlm.nih.gov/37807924/ KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease https://pubmed.ncbi.nlm.nih.gov/38490803/ Heart Failure in Patients With Chronic Kidney Disease https://pubmed.ncbi.nlm.nih.gov/37763045/ Lokelma Prescribing Information https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/6de8f71b-d3af-4f76-9600-907c98616be6/6de8f71b-d3af-4f76-9600-907c98616be6_viewable_rendition__v.pdf Sodium Zirconium Cyclosilicate in Hyperkalemia https://pubmed.ncbi.nlm.nih.gov/25415807/ Veltassa Prescribing Information https://veltassa.com/pi Patiromer for the Management of Hyperkalemia in Heart Failure With Reduced Ejection Fraction: The DIAMOND Trial https://pubmed.ncbi.nlm.nih.gov/35900838/ Sodium Zirconium Cyclosilicate in HFrEF and Hyperkalemia: REALIZE-K Design and Baseline Characteristics https://pubmed.ncbi.nlm.nih.gov/38878009/ Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes https://pubmed.ncbi.nlm.nih.gov/33264825/ Finerenone Reduces Risk of Incident Heart Failure in Patients With Chronic Kidney Disease and Type 2 Diabetes: Analyses From the FIGARO-DKD Trial https://pubmed.ncbi.nlm.nih.gov/34775784/ Press Release: First Patient Enrolled in CARE-HK in HF to Evaluate Role of Veltassa® (Patiromer) in Enabling RAASi Treatment https://newsroom.csl.com/2021-04-28-First-patient-enrolled-in-CARE-HK-in-HF-to-evaluate-role-of-Veltassa-R-patiromer-in-enabling-RAASi-treatment Medical Therapy for Heart Failure With Reduced Ejection Fraction: The CHAMP-HF Registry https://pubmed.ncbi.nlm.nih.gov/30025570/ Finerenone in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction: Rationale and Design of the FINEARTS-HF Trial https://pubmed.ncbi.nlm.nih.gov/38742248/ Additional Studies With Finerenone Across a Wide Range of Heart Failure Patients Initiated https://www.bayer.com/media/en-us/additional-studies-with-finerenone-across-a-wide-range-of-heart-failure-patients-initiated/ Treatment Effects of Empagliflozin in Hospitalized Heart Failure Patients Across the Range of Left Ventricular Ejection Fraction — Results From the EMPULSE Trial https://pubmed.ncbi.nlm.nih.gov/38572654/ Safety, Tolerability and Efficacy of Up-Titration of Guideline-Directed Medical Therapies for Acute Heart Failure (STRONG-HF): A Multinational, Open-Label, Randomised, Trial https://pubmed.ncbi.nlm.nih.gov/36356631/ Steroidal MRA Across the Spectrum of Renal Function: A Pooled Analysis of RCTs https://pubmed.ncbi.nlm.nih.gov/36328653/

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