No Priors: Artificial Intelligence | Technology | Startups

By the end of 2026, AI capital expenditure is projected to hit nearly $700 billion. The question isn’t who has the best model, but who has the most creative financing to build out AI infrastructure and beyond. Sarah Guo is joined by Neil Tiwari, Managing Director at Magnetar Capital, a financial innovator helping the AI industry scale from billions to trillions of dollars in CapEx. Neil explains some of the debt structures used to finance massive GPU clusters, who is taking the risk, and how the industry is maturing. Sarah and Neil also discuss how power distribution, energy storage, and physical materials like steel are the bottlenecks of the AI industry. Plus, Neil gives his take on the future of inference-optimized clouds, and why the market shift away from software and into infrastructure might be an overreaction.

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Chapters:

00:00 – Cold Open

00:05 – Neil Tiwari Introduction

00:26 – Magnetar’s Story

01:28 – Why CoreWeave Helped Magnetar Win

06:15 – Scaling CapEx Efficiently

09:02 – Debunking GPU Collateral Risk

11:42 – How Deal Structures Evolve

13:01 – What Bottlenecks Buildout

15:28 – Circular Financing Critiques

17:35 – The Shift from Training to Inference Workloads

23:10 – AI Factories

24:12 – Constraints of the Current Power Grid

28:27 – Sovereign Compute Buildouts

29:54 – Physical AI Capital Needs

32:48 – The Capital Rotation Away from SaaS

36:04 – Conclusion

In this episode of No Priors, Sarah and Elad dive into the evolving landscape of software, exploring how AI is transforming the traditional SaaS model. They discuss whether SaaS as we know it is coming to an end, what new business and sales strategies are emerging, and how AI is reshaping the way software is built, sold, and scaled. The conversation also examines whether or not these shifts are a good thing for both big and small companies, and how coders and software experts are reacting to abrupt AI transitions. They also dig into how AI is reshaping sales, automating workflows, and enabling more predictive customer strategies. Beyond individual companies, they examine how tech giants are increasingly dominating the S&P 500, and what this concentration of power means for the future of startups, innovation, and the broader entrepreneurial ecosystem.

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Chapters:

00:00 – Cold Open

00:35 – The SaaS-polcalypse discussion 

4:55 – AI Change Management in Large vs. Small Companies

05:43 – “Is Software Eating the World?” 

08:38 – Addressing the Unsolved Problems 

14:00 – The Noise of the Last Month vs. Excitement 

21:32  – What Proportion of GDP is Tech? 

23:20 – Market Cap Shifts

25:02 – As a Company, When Should You Sell? 

29:05 – Multi-Product Bundle Defense 

30:45 – Conclusion

Autonomous vehicle technology has moved past human-coded rules and into an era of neural networks and custom computer chips. And to solve the most difficult driving scenarios, electric vehicle company Rivian abandoned its original technology platform to build a vertically integrated data stack. Sarah Guo sits down with Rivian Founder and CEO RJ Scaringe to explore the seismic shift in the automotive industry toward AI-driven, software-defined vehicles . RJ discusses the move away from function or domain-based architecture for vehicle electronic systems to software-defined architecture, which allows for dynamic, monthly updates to features in Rivian’s vehicles. RJ also talks about the upcoming launch of Rivian’s R2 model, which aims to be a distinct, affordable, mass-market alternative to the Tesla Model Y. Plus, RJ shares his vision for a future where vehicles don’t just drive us, but inspire personal freedom and exploration.

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Chapters:

00:00 – Cold Open00:35 – RJ Scaringe Introduction0:58 – Rivian’s Autonomy Evolution05:19 – Why Rivian’s Tech is Vertically Integrated10:06 – Levels of Autonomous Driving Technologies14:00 – Importance of a Software-Defined Architecture19:28 – Differentiating Autonomous Vehicle Models23:20 – R2: The First Mass Market Autonomous Vehicle25:02 – Do Americans Want EVs?29:05 – How Our Relationship to Vehicles is Evolving30:45 – Conclusion

From “virtual doppelgängers” to “real-time dreaming,” online gaming platform Roblox is using AI technology to build the “Holodeck” envisioned in science fiction decades ago. Sarah Guo and Elad Gil sit down with Roblox CEO Dave Baszucki at Roblox headquarters to explore the intersection of AI, physics simulation, and the future of human connection. Dave discusses the evolution of the 4D creation tool in Roblox, a high-fidelity simulation that enables thousands of people to interact in real-time with photo-realistic graphics and acoustic physics. Dave reveals how Roblox is leveraging 13 billion hours of monthly user data to train native AI models that go beyond simple LLMs, enabling NPCs that can navigate and play games with human-like intuition. He also talks about how immersive communication will change video conferencing, how Roblox searches for unlikely talent outside of traditional elite universities, and how he balances rapid weekly iterations with keeping a “long view” on Roblox’s vision. 

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Chapters:

00:00 – Cold Open

00:36 – Dave Baszucki Introduction

01:16 – Realizing Robolox’s 20-Year Vision

05:29 – Using 4D Immersive Simulations in Virtual Interactions

08:22 – Physics Engine vs. Photorealism 

11:50 – Storing Roblox History as Vector Data

14:00 – Training NPCs - Moving Beyond LLMs

18:05 – The Future of the Game Designer

19:54 – Video Latent World Models

23:53 – Social Simulation - AI Companions and Virtual Relationships

27:26 – Why Asset Costs Haven’t Changed the Gaming Industry

29:52 – AI Coding in Roblox Studio

31:36 – The Roblox Creator Economy

33:57 – Long-Term Conviction vs. Weekly Iteration

37:50 – Dave’s Hiring Philosophy for Roblox

43:44 – Conclusion

What if we could pause biological time to wait for a cure for a disease? Thanks to innovations and research in reversible cryopreservation, this possibility is no longer just science fiction. Sarah Guo sits down with Laura Deming, CEO and co-founder of biotech startup Until, to dive deep into the growing field of reversible cryopreservation. Laura talks about how her time as a Thiel Fellow as well as her founding of the Longevity Fund fueled her obsession with solving the “social blindspot” of aging. Laura details how her new startup, Until, seeks to build tools that allow for “pressing pause” on biological time, starting with human organs with the hopes of scaling up to full body medical hibernation. Together, they also discuss why ice is the enemy of tissue, using engineering tools to help solve biological problems, and how this technology may revolutionize organ transplantation by removing time as a variable. 

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Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil | @LauraDeming | @untillabs 

Chapters:

00:00 – Cold Open

01:08 – Laura Deming Introduction

01:53 – Why Laura Focused on Cryo Preservation and Longevity

06:20 – Bringing on Co-Founder Hunter Davis

07:55 – Until’s Goal

10:10 – Other Use Cases for Cryo Technology

12:22 – Scientific Challenges in Cryo Tech

15:36 – Using Engineering Principles to Solve Biological Problems

20:18 – Scaling Up Cryo Preservation

21:48 – Leading and Recruiting at Until

25:02 – Why Hasn’t Cryo Tech Been Worked On More?

27:14 – Making Time Not a Variable in Organ Transplants 

29:06 – Changing How the Molecular World is Depicted

30:47 – Conclusion