Psychopharmacology and Psychiatry Updates

In this episode, we explore what to do when antidepressants aren't working. How do you systematically approach a patient who isn't getting better — and when do you switch versus augment? Dr. Sagar Parikh walks through CANMAT's evidence-based framework for difficult-to-treat depression.
Faculty: Sagar V. Parikh, M.D., F.R.C.P.C.
Host: Richard Seeber, M.D.
Learn more about our memberships here
Earn 1.25 CME: Rethinking Depression Treatment: An Update of CANMAT's Guidelines
Pharmacologic Management of Difficult-to-Treat Depression: First, Second, and Third Line Options

In this episode, we explore whether high-dose olanzapine — beyond the FDA-approved 20 mg ceiling — can be a viable strategy for patients with treatment-resistant schizophrenia when clozapine isn't yet an option. Can pushing the dose bridge the gap between partial response and full remission?
Faculty: Oliver Freudenreich, M.D.
Host: Richard Seeber, M.D.
Learn more about our membership here
Earn 0.75 CME: Quick Take Vol. 83
Treatment-Resistant Schizophrenia: Should You Consider High-Dose Olanzapine Instead of Clozapine?

In this episode, we explore what the CANMAT guidelines say about complementary and alternative medicine (CAM) for depression — from St. John's wort to saffron — and how to have evidence-based, collaborative conversations with patients who prefer a more natural approach to treatment.
Faculty: Sagar V. Parikh, M.D., F.R.C.P.C.
Host: Richard Seeber, M.D.
Learn more about our memberships here
Earn 1.25 CME: Rethinking Depression Treatment: An Update of CANMAT's Guidelines
Complementary and Alternative Medicine for Depression: CANMAT Recommendations

In this episode, we explore the growing threat of xylazine — a veterinary sedative increasingly found in illicit drug supplies — and what clinicians need to know when naloxone simply isn't enough. Dr. David Gorelick breaks down the current evidence on diagnosis, treatment, and the critical gaps that remain.
Faculty: David A. Gorelick, M.D., Ph.D., D.L.F.A.P.A., F.A.S.A.M.
Host: Richard Seeber, M.D.
Learn more about our membership here
Earn 0.5 CME: Quick Take Vol. 82
Xylazine ("Tranq Dope") Overdose: What Clinicians Should Know

In this episode, we explore how to select the right initial treatment for depression using the updated CANMAT guidelines. How do severity, patient preference, and treatment availability shape your first clinical move? Dr. Sagar Parikh breaks down the evidence on psychotherapy, antidepressants, and when to combine both.
Faculty: Sagar V. Parikh, M.D.
Host: Richard Seeber, M.D.
Learn more about our memberships here
Earn 1.25 CME: Rethinking Depression Treatment: An Update of CANMAT's Guidelines
Selecting the Initial Depression Treatment