

Beyond Bioavailability — What Research Shows About Flavanols' Effectiveness
22/12/2025 | 8 mins.
Flavanols are plant compounds in cocoa, berries, and tea with low bioavailability, meaning only a small portion enters the bloodstream A new animal study found that oral flavanol doses of 25 to 50 milligrams per kilogram (mg/kg) activated the subjects' brains within minutes Flavanols are a type of flavonoid within the polyphenol family. This hierarchy clarifies their differences and explains why foods have unique combinations that offer specific health benefits If you choose cocoa flavanol supplements, don't fall for flashy marketing; whenever possible, stick to a nutritious food-first approach Along with consuming flavanol-rich foods, pairing them with regular physical activity and a nutrient-dense, plant-focused diet helps support long-term brain health and cardiovascular resilience

Butyrate — The Metabolic Powerhouse Fueling the Gut and Beyond
22/12/2025 | 7 mins.
Butyrate, a short-chain fatty acid produced by gut bacteria that ferment dietary fiber, helps improve metabolic health by enhancing insulin function, regulating glucose levels and supporting healthy body composition Unlike most cells that use glucose, colonocytes (the epithelial cells that line your colon) prefer butyrate for energy, converting 70% to 80% through beta-oxidation to maintain gut barrier health Promoting butyrate production through fiber intake is beneficial, but only if your gut is healthy. If your gut is compromised, starting with dextrose water before transitioning to whole foods is recommended Lifestyle factors significantly impact butyrate production, with chronic stress, smoking, excessive drinking and antibiotic overuse reducing beneficial gut bacteria and SCFA production Excessive linoleic acid consumption, common in processed foods and vegetable oils, reduce beneficial gut bacteria, negatively affecting gut and metabolic health

A Breakthrough in Understanding Long COVID
20/12/2025 | 7 mins.
People with long COVID experience persistent fatigue, breathlessness, and brain fog. Research links these effects to fibrin microclots intertwined with neutrophil extracellular traps that obstruct microvessels and impair oxygen delivery SARS-CoV-2 pushes blood into a hypercoagulable state, damaging endothelium, activating platelets, and inflammatory cytokines. This causes clot risk to persist for months, even after mild infections and hospital discharge Long COVID essentially boils down to mitochondrial dysfunction. Management includes proteolytic enzymes to help clear spike protein, while the I-RECOVER protocol guides detoxification, inflammation control, and mitochondrial repair to restore overall function Protecting cardiolipin, the mitochondrial membrane fat, requires limiting easily oxidized linoleic acid (LA) from seed oils, processed foods, nuts, seeds, and grain-fed meats Methylene blue may enhance mitochondrial respiration at low doses. Additionally, correcting copper deficiency and lowering excess iron through blood donation support energy production

Taking Melatonin Does Not Increase Your Risk of Heart Failure
20/12/2025 | 7 mins.
A preliminary American Heart Association (AHA) study linked long-term melatonin use to increased heart failure risk, but a closer analysis shows serious flaws, including lack of peer review and failure to account for confounding variables The study found melatonin users had 90% higher heart failure rates, but data mixed together prescription-only countries with over-the-counter markets, misclassifying many actual users as non-users Moreover, the study failed to account for insomnia severity, psychiatric conditions, other medications, and dosing details, making it impossible to determine if melatonin caused the observed outcomes Decades of peer-reviewed research demonstrates melatonin's cardioprotective effects, including reducing blood pressure, protecting heart tissue, and mitigating oxidative damage, contradicting the study's alarming headlines While supplementation is unlikely to pose serious risks, there are natural ways to optimize your melatonin production, such as getting morning sunlight exposure, keeping a consistent sleep schedule, limiting evening blue light, eating earlier, and practicing stress-reduction techniques

Bedroom Ventilation for Better Sleep — What the Latest Research Shows
20/12/2025 | 6 mins.
A recent study reveals that bedroom ventilation plays an essential role in sleep quality. Carbon dioxide (CO₂) levels need to remain below 1,000 ppm, ideally under 800 ppm, for deeper, uninterrupted sleep Opening windows can help with airflow, but it's not always ideal due to outdoor pollutants, noise, or security risks. In such cases, a ventilation system is a safer and more reliable option Air purifiers filter indoor air but do not introduce fresh air. To maintain optimal air quality, pair filtration systems with proper ventilation rather than relying on one system alone Monitoring CO₂ levels in your bedroom helps ensure proper air exchange. Using a reliable CO₂ meter provides insight into ventilation efficiency and allows adjustments to improve sleep quality To further improve indoor air quality, regularly clean or replace air filters, minimize the use of synthetic air fresheners, scented candles, and harsh cleaning chemicals, opt for natural, nontoxic alternatives, and air out your home safely



Dr. Joseph Mercola - Take Control of Your Health