In this week's podcast episode in the Nutrition After Breast Cancer: Just the Facts series, I bring up the study that sparked that concern. I don't ignore things like this. I don't pretend they don't exist. If there's research being talked about, I want you to know about it.
But here are the actual facts.
The study was done in mice.
The mice were made to consume about 40% of their diet in olive oil.
And the rest of their diet was an obesogenic, high-carbohydrate diet designed to promote weight gain and metabolic dysfunction.
That is not a Mediterranean diet.
That is not olive oil drizzled over vegetables and salmon.
That is not real life.
It was a laboratory model designed to stress metabolism.
Context matters. Deeply.
Resources Mentioned:
Guide to Essential Fatty Acids:
https://www.thebreastcancerrecoverycoach.com/oil
Episode #326 Simplifying Seed Oils and Fatty Acids After Breast Cancer
https://www.thebreastcancerrecoverycoach.com/326
Work with Laura:
https://www.thebreastcancerrecoverycoach.com/health
REFERENCES:
Obesity and Low-Fat Diet History
Trends in Obesity Among Adults in the United States, 2005 to 2014 (CDC) https://www.cdc.gov/mmwr/preview/mmwrhtml/su6001a15.htm
Documents obesity prevalence: 15.0% (1976-1980), 23.3% (1988-1994)
Adult Obesity Prevalence Maps (CDC) https://pmc.ncbi.nlm.nih.gov/articles/PMC9611578/
30.9% obesity prevalence (1999-2000)
Adult Obesity Prevalence, 2021-2023 (CDC) https://www.cdc.gov/nchs/products/databriefs/db508.htm
Current obesity prevalence: 40.3%
How the Ideology of Low Fat Conquered America https://pubmed.ncbi.nlm.nih.gov/18296750/
Historical analysis of the low-fat movement
Heart Disease Mortality
Explaining the Decrease in U.S. Deaths from Coronary Disease, 1980–2000 (Ford et al., NEJM 2007) https://www.nejm.org/doi/full/10.1056/NEJMsa053935
~51% decline in men, ~49% decline in women
47% from medical treatments, 44% from risk factor changes
Obesity and diabetes offset gains by 8% and 10%
Heart Disease Mortality in the United States, 1970 to 2022 https://www.ahajournals.org/doi/10.1161/JAHA.124.038644
89% decrease in heart attack deaths
81% increase in heart failure and other heart disease deaths
Omega-3s, Inflammation, and Cancer
Omega-6/Omega-3 Ratios and Modern Diets
Ancestral ratios: 1:1 to 4:1
Modern Western diet: 15:1 to 20:1
Impact on eicosanoid metabolism and cellular inflammation
DHA and Triple Negative Breast Cancer (Journal of Nutritional Biochemistry, 2019)
DHA induced cell death in TNBC cells
Mechanism: altered membrane composition, increased oxidative stress in cancer cells
High-Fat Diets and TNBC Metastasis (Preclinical Studies)
CD36-mediated fatty acid uptake in TNBC
Oleic acid-rich diets promoting metastasis in mouse models
Importance of tumor phenotype and metabolic flexibility
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Ireland