The Biotech Startups Podcast

The conversation then turns to product management. Nathan describes the discipline as understanding why a product should exist, grounding decisions in user needs, and translating research into what a team builds. His advice for early-stage founders is direct: stop coding until they've done enough customer research to understand the problem.

Nathan Clark reflects on the formative influence of his entrepreneurial father, who showed him that business and even home building are learned through research, effort, and execution rather than secret insight. Nathan also discusses his unconventional high school experience, his decision to study business and finance at the University of North Carolina, and the early interest in biology and futurism that stayed with him.

David Li explains how a research question about mischaracterized drug targets became the starting point for Meliora Therapeutics. He describes how CRISPR experiments and follow-up biology challenged the accepted mechanism for cancer drugs, and how the company uses AI and machine learning to connect chemistry, biology, biomarkers, and patient populations.

In this part of the podcast, David Li, CEO and co-founder of Meliora Therapeutics, reflects on his experience helping build Everest Detection around the challenge of finding lung cancer earlier. He discusses the potential of a noninvasive, blood-based test, why lung cancer can be difficult to detect in blood, and how access to early-stage clinical samples helped the team investigate the problem.

In this part of the podcast, David Li reflects on leaving finance after realizing that an investing career would not give him the tangible impact he wanted. He explains what KKR taught him about business and patient needs, then describes the team-and-market test that led him to Benchling.