Freely Filtered, a NephJC Podcast

The Filtrate
Joel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)
Sophia Ambruso @sophia-kidney.bsky.social
Swapnil Hiremath @hswapnil.medsky.social and on LinkedIn
Special Guests
Jonathan Barratt Professor of Renal Medicine, University of Leicester Google Scholar (COI: all the companies)
Editing and Show Notes by
Nayan Arora @captainchloride.bsky.social
The Kidney Connection written and performed by Tim Yau
Show Notes
Proteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy (Aliza Thompson, 2019 PubMed)
The number, quality, and coverage of randomized controlled trials in nephrology (PubMed 2004)
A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction (PubMed 2017)
BLISS Belimumab in lupus nephritis (NephJC | PubMed)
The Phase 2 trial of atacicept A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy (PubMed)
The phase 3 trial of atacicept, the subject of this podcast A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (PubMed | NephJC)
The use of Gd-IgA1 in the Testing Trial Role of Systemic Glucocorticoids in Reducing IgA and Galactose-Deficient IgA1 Levels in IgA Nephropathy (PubMed)
If you can’t get enough Jon Barratt, take a look at his grand rounds at The University of Ottawa. Updates to the KDIGO Guidelines for the treatment of IgA nephropathy, with Prof Jonathan Barratt (YouTube)
Tubular Secretion
Swapnil Hiremath Pluribus on Apple TV (Wikipedia)
Jon Barratt Lynyrd Skynyrd (Wikipedia) Slow Horses (Wikipedia) on AppleTV
Joel Topf the new ASN

The Filtrate
Joel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)
Pedro Teixeira @nephcrit.bsky.social
Ana Gaddy @AnnaGaddy
Nayan Arora @captainchloride.bsky.social
Special Guests
David Goldfarb Professor of Medicene, NYU (COI)
Editing by
Pedro Teixeira
The Kidney Connection written and performed by Tim Yau
Show Notes
BICARBICU 2018 (Lancet)
BICARBICU-2 2025 (JAMA)
SOFA score (Wikipedia)
Sodium bicarbonate administration for metabolic acidosis in the intensive care unit: a target trial emulation (PubMed)
Effect of sodium bicarbonate on intracellular pH under different buffering conditions (PubMed)
Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC) (ICNARC Site)
SODium BICarbonate for Metabolic Acidosis in the ICU (SODa-BIC) (ClinicalTrials.gov)
Surviving Sepsis Campaign Guidelines 2021 (Website)
Tubular Secretions
Nayan: Louise Penny, The Black Wolf (Amazon)
Anna: Broom Gate: A Curling Scandle (CBC)
Pedro: One Battle After Another! (Wikipedia)
David: Patti Smith (Wikipedia)
Bonus pick: Kids Rarely Read Whole Books Anymore. Even in English Class. (NYT)
Joel: Boys in the Boat by Daniel James Brown (Film Wikipedia | Book Wikipedia)

The Filtrate
Joel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)
Swapnil Hiremath @hswapnil.medsky.social and on LinkedIn
Pedro Teixeira @nephcrit.bsky.social
Special Guests
Charmaine E Lok, MD Professor of Medicine at the Faculty of Medicine, University of Toronto
Editing and Show Notes by
Joel Topf
The Kidney Connection written and performed by Tim Yau
Show Notes
Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis NEJM | NephJC
What works in hemodialysis?
Iron: PIVOTAL Trial (NEJM)
Hemodiafiltration: CONVINCE (NEJM)
That’s the whole list
Earlier work on vascular access, The FISH Trial: Effect of fish oil supplementation on graft patency and cardiovascular events among patients with new synthetic arteriovenous hemodialysis grafts: a randomized controlled trial JAMA
Eskimo myth: "Fishing" for the origins of the "Eskimos and heart disease" story: facts or wishful thinking? (PubMed)
Dialysis patients have low levels of fish oil in their body (PubMedCentral)
Positive trial in non-dialysis patients: REDUCE-IT
Negative trial of fish oil in non-dialysis patients: STRENGTH
ACC does not recommend FISH Oil for primary or secondary prevention of CV events (ACC)
Poisson distribution (Wikipedia)
Ocean Nutrition Canada (Wikipedia)
Ocean Nutrition was bought by DSM (Press Release)
DSM merged with Firmenich (Press Release)
Vanguard feasibility trials (PubMed)
Freezing fish oil caps will eliminate the fishy aftertaste (Pharmacists Letter)
The study also received a philanthropic donation from Mr. Alexander Epstein (UHN Research)
Selection Bias, Interventions and Outcomes for Survivors of Cardiac Arrest (PubMedCentral)
Effectiveness of fish oil in controlling inflammation in adult patients undergoing hemodialysis: A systematic review and meta-analysis (PubMed)
Tubular Secretions
Swapnil Hiremath: Michael Clayton (IMDB)
Pedro: Fifa World Cup Soccer coming to North America with Portugal! (FIFA)
Charmaine: New Puppy, Rose. It’s a Barbet (Wikipedia)
Joel Topf: The Dark Forrest by Liu Cixin (Wikipedia)

The Filtrate
Joel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)
Sophia Ambruso @sophia-kidney.bsky.social
Swapnil Hiremath @hswapnil.medsky.social and on LinkedIn
Special Guests
Jonathan Barratt Professor of Renal Medicine, University of Leicester Google Scholar (COI: all the companies)
Editing and Show Notes by
Nayan Arora @captainchloride.bsky.social
The Kidney Connection written and performed by Tim Yau
Show Notes
Proteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy (Aliza Thompson, 2019 PubMed)
The number, quality, and coverage of randomized controlled trials in nephrology (PubMed 2004)
Updated here (PubMed | NephJC discussion)
A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction (PubMed 2017)
BLISS Belimumab in lupus nephritis (NephJC | PubMed)
The Phase 2 trial of atacicept A phase 2b, randomized, double-blind, placebo-controlled, clinical trial of atacicept for treatment of IgA nephropathy (PubMed)
The phase 3 trial of atacicept, the subject of this podcast A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (PubMed | NephJC)
Christos’ Bluesky post:
https://bsky.app/profile/christosargyrop.bsky.social/post/3m5bsujwg3s2q
The use of Gd-IgA1 in the Testing Trial Role of Systemic Glucocorticoids in Reducing IgA and Galactose-Deficient IgA1 Levels in IgA Nephropathy (PubMed)
If you can’t get enough Jon Barratt, take a look at his grand rounds at The University of Ottawa. Updates to the KDIGO Guidelines for the treatment of IgA nephropathy, with Prof Jonathan Barratt (YouTube)
Tubular Secretion
Swapnil Hiremath Pluribus on Apple TV (Wikipedia)
Jon Barratt Lynyrd Skynyrd (Wikipedia) Slow Horses (Wikipedia) on AppleTV
Joel Topf the new ASN

The Filtrate
Joel Topf‍ ‍@kidneyboy.bsky.social‬
Sophia Ambruso @sophia-kidney.bsky.social
Nayan Arora @captainchloride.bsky.social
Special Guests
Brian Rifkin @brianrifkin.bsky.social
Anna Gaddy @AnnaGaddy
Editing and Show Notes by
Joel Topf
The Kidney Connection written and performed by Tim Yau
Show Notes
Brian Rifkin and Cristina Popa ascend to co-editors in chief of NephJC.

Paresh Jadav receives the first NephJC Champion award. Dr. Jadav hosted the NephJC night and saved NephJC thousands of dollars. It makes a huge difference in our fund raising. Thank you.
Also a big thank-you to Jade Teakell for buying the cowboy hats!
The first pick of the draft, by Sophia is Fish oil for dialysis: Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis (NEJM)

The second pick, by Brian is FINE-ONE (Bayer Press release)
Rajiv Agarwal’s mediation analysis to show how much of finerenone’s beneficial renal effects are captured by the reduction proteinuria: Impact of Finerenone-Induced Albuminuria Reduction on Chronic Kidney Disease Outcomes in Type 2 Diabetes : A Mediation Analysis (PubMed)
Anna has the third pick and it goes to Katherine Tuttle and the REM0DEL Trial: REMODELing mechanistic trials for kidney disease: a multimodal, tissue-centered approach to understand the renal mechanism of action of semaglutide (Science Direct)
Nayan goes off-board and picks a poster by a med student (backed by Testani)
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure (ClinicalTrials.gov)
For the final pick in the draft Joel went with a little Lilly on Lilly violence: Tirzepatide vs. Dulaglutide Is Associated with Reduced Major Kidney Events in Patients with Type 2 Diabetes, CVD, and Very High-Risk Kidney Diseases (JASN)
Bring out your dead…What’s left on the draft board.
Liberate-D A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury: The Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial (JAMA)
Atacicept for IgAN A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (NEJM)
Lilia Cervantes crushed it with Community Health Worker Support for Hispanic and Latino Individuals Receiving Hemodialysis: The Navigate-Kidney Randomized Clinical Trial (JAMA)
Tubular Secretion
Brian: Late Breaking and High Impact Clinical Trials. Including Sibe! REGENCY Biopsy Data.
Sophia: Flying Home. No, really it’s the Electrolyte Quiz
Joel: The Poster Session, the Quiz Session, and
Nayan: Flying to AHA to talk about dual-heart-kidney-transplant
Anna: Kidney STARS! and Melanie Hoenig’s session on potassium