Freely Filtered, a NephJC Podcast

The Filtrate
Joel Topf kidneyboy.bsky.social
Swapnil Hiremath @hswapnil.medsky.social
Pedro Teixeira @nephcrit.bsky.social

Special Guests
Ewout J. Hoorn, Professor of Medicine Erasmus MC, Netherlands. One of the primary authors.
Harish Seethapathy, Assistant physician at Massachusetts General Hospital

Editing
Vipin Verghese
The Kidney Connection written and performed by Timothy Yau

Show Notes
A Randomized Trial of Targeted Hyponatremia Correction in Hospitalized Patients in NEJM Evidence, in PubMed, in NephJC
Seethapathy: Severe Hyponatremia Correction, Mortality, and Central Pontine Myelinolysis in NEJM Evidence
MacMillan: Osmotic Demyelination Syndrome in Patients Hospitalized with Hyponatremia in NEJM Evidence
SALSA: Risk of Overcorrection in Rapid Intermittent Bolus vs Slow Continuous Infusion Therapies of Hypertonic Saline for Patients With Symptomatic Hyponatremia: The SALSA Randomized Clinical Trial in JAMA Internal Medicine
SALT 1 and 2: Tolvaptan, a Selective Oral Vasopressin V2-Receptor Antagonist, for Hyponatremia in NEJM
Hyponatremia registry: Current treatment practice and outcomes. Report of the hyponatremia registry in Kidney International
The Richard Sterns’ article on the lower mortality with more severe hyponatremia: Mortality and Serum Sodium: Do Patients Die from or with Hyponatremia? in CJASN
The European Hyponatremia Guidelines: Clinical practice guideline on diagnosis and treatment of hyponatraemia in The European Journal of Endocrinology
The American Hyponatremia Guidelines: Diagnosis, Evaluation, and Treatment of Hyponatremia: Expert Panel Recommendations in American Journal of Medicine
Treating hyponatremia: damned if we do and damned if we don't by Tom Berl in Kidney International
Prospective (clamp) versus reactive (rescue) DDAVP in hyponatremia: Safety and efficacy of proactive versus reactive administration of desmopressin in severe symptomatic hyponatremia: a randomized controlled trial in Nature Scientific Reports and as covered in PBFluids
Helbert Rondon’s RCT of urea Urea for Chronic Hyponatremia on ClinicalTrials.gov
Tubular Secretions
Swapnil: Catfishing on CatNet: A Novel by Naomi Kritzer (Amazon)
Harish: Disney Cruise
Edward: Flesh: A Novel (Booker Prize Winner) by David Szalay (Amazon)
Pedro: Scrubs reboot (IMDB)
Joel: KIDNEYcon

The Filtrate
Joel Topf kidneyboy.bsky.social

Special Guests
Dr. Samir Parikh, President of the American Society of Nephrology
Prof. Donal Reddan, President, Irish Nephrology Society
Prof. Catherine Godson
Editing
Joel Topf
The Kidney Connection written and performed by Timothy Yau

Show Notes

Tubular Secretions
Joel Topf, the Dublin Port Greenway Link
Catherine Godson: never heard of the Dublin Port Greenway
Samir Parikh: Trinity College Dublin and specifically the Eavan Boland Library, named after the Irish poet.
Donal Reddan: Something about rugby

The Filtrate
Joel Topf kidneyboy.bsky.social
Pedro Teixeira @nephcrit.bsky.social
Nayan Arora @captainchloride.bsky.social
Anna Gaddy @annagaddy.bsky.social
Swapnil Hiremath @hswapnil.medsky.social and on LinkedIn

Special Guests
Ian McCoy, MD @NephroNinja study author and UCSF
Chi-yuan Hsu Senior author and Chief of the Division of Nephrology at UCSF
Samuel Silver Associate Professor at Queens University in Canada
Editing
Vipin Verghese and Joel Topf

Show Notes
NephJC Discusion: Dialyze Less, Recover More? AKI’s Chance to Get LIBERATE-D
Manuscript: A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney InjuryThe Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial JAMA | PubMed
Ben’s pilot study: RAD-AKI Pilot study: Recovery After Dialysis-Requiring Acute Kidney Injury (RAD-AKI) (ClinicalTrials.gov)
STARRT-AKI NephJC
Editorial in JAMA: A-E-I-O-U and Sometimes Why—Dialysis in Acute Kidney Injury (JAMA)
What Is Dialytrauma? (Nephrology Times)
How Fragile Are the Results of a Trial? The Fragility Index (PubMedCentral)
Shiffl Trial: Daily Hemodialysis and the Outcome of Acute Renal Failure (NEJM)
AKIKI: Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit (NEJM)
AKIKI2: How Late it was, How Late! (NephJC)
Sam Silver’s study: Promoting Kidney Recovery After Acute Kidney Injury Receiving Dialysis (Recover-AKI) (ClinicalTrial.Gov)
Marie Kondo (Wikipedia)
Tubular Secretions
Swap: The smutty dragon novels of novels of Rebecca Yarros (Wikipedia) Specifically The Empyrean series
Anna: Brisket recipes
Pedro: The Naked Gun (Wikipedia) with Liam Neeson
Ian: ASN Kidney Health Guidance on the Outpatient Management of Patients with Dialysis-Requiring Acute Kidney Injury (PubMed) he really doesn’t get Tubular Secretions.
Nayan: Tilt: A Novel by Emma Pattee (Amazon)
Chi: The Year of Magical Thinking by Joan Didion (Wikipedia) and Innovations in Nephrology (Springer Nature)
Sam: Monopoly Super Electronic Banking Board Game (Amazon)
Joel: Song Sung Blue (Wikipedia)

The Filtrate
Joel Topf (kidneyboy.bsky.social)
AC (@medpeedskidneys.bsky.social)NephMadness
Anna Gaddy (@AnnaGaddy)
Vipin Verghese (@vipvargh.bsky.social)
Natalie Freidin Program director at Medical University of South Carolina
Special Guests
Anna Vinnikova (@kidneywars.bsky.social) Long time game maker for NephMadness and Associate Professor at Virginia Commonwealth University
Autumn Harris Associate Professor of Veterinary Medicine at NC State
Sarah Street MD PhD Assistant Professor of Medicine at Virginia Commonwealth University
Editing
Joel Topf
Show Notes
Animal House scouting report
Autumn Harris on Team Cat
Cheese!

I know 2026 feels like it ihas been here for months, but only a few weeks ago we were celebrating the nephrology accomplishments of 2025. The New Filtrate came together to review the year.

The Filtrate
Joel Topf‍ ‍@kidneyboy.bsky.social‬ (COI)
Swapnil Hiremath @hswapnil.medsky.social and on LinkedIn Editor in Chief of Kidney International Case Reports
Anna Gaddy (@AnnaGaddy) Winner of NephJC Rookie of the Year 2020
Nayan Arora (@CaptainChloride.bsky.social)
AC (@medpeedskidneys.bsky.social)
Vipin Verghese (@vipvargh.bsky.social) co-winner of NephJC Engaged Scientist of the Year in 2021
Brian Rifkin (@brianrifkin.bsky.social) Co-Editor in Chief NephJC. Winner of NephJC Rookie of the Year 2021
Cristina Popa (@NephroSeeker) Co-Editor in Chief NephJC. Wwinner of NephJC Rookie of the Year 2022 and MVP 2023

Editing and Show Notes by
Anna Gaddy and Joel Topf
The Kidney Connection written and performed by Tim Yau
Show Notes
Top Stories in Nephrology 2025 (NephJC)
First Top sories in Nephrology 2010! (Renal Fellow Network)
Links to all of the Top Stories in Nephrology, hosted on NephJC since 2017 (NephJC)
1. IgA Nephropathy
VISIONARY: Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial (NEJM)
ORIGIN 3: A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (NEJM)
APPLAUSE-IgA Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy (NEJM)
Aliza M. Thompson, MD, MS (ASN)
2. Lupus Nephritis
REGENCY: Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis (NEJM)
3. Nobel prize winner and peripheral immune tolerance
4. Xenotransplantation
5. GLP1ra Revolution
Remodel REMODELing mechanistic trials for kidney disease: a multimodal, tissue-centered approach to understand the renal mechanism of action of semaglutide (Kidney International)
SURPASS-CVOT Tirzepatide vs. Dulaglutide Is Associated with Reduced Major Kidney Events in Patients with Type 2 Diabetes, CVD, and Very High-Risk Kidney Diseases (Kidney Week abstract in JASN)
Poll: 1 in 8 Adults Say They Are Currently Taking a GLP-1 Drug for Weight Loss, Diabetes or Another Condition, Even as Half Say the Drugs Are Difficult to Afford (KFF survey)
6. GDMT implementation in CKD: lessons learnt from CONFIDENCE and MIRO-CKD
Confidence Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes (NEJM)
MIRO-CKD Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial (The Lancet)
7. Flozin Meta analysis
SMART-C. SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria. A Meta-Analysis (JAMA)
SMART-C. Effects of Sodium Glucose Cotransporter 2 Inhibitors by Diabetes Status and Level of Albuminuria. A Meta-Analysis (JAMA)
8. Paradigm Shift: Aiming for CKD Remission
9. Fish Oil and Dialysis
PISCES Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis (NEJM)
10. Decline in Dialysis Patients in the United States
USRD 2025 Annual Data Report (USRDS)
Tubular Secretion
Swapnil Hiremath Alien Earth on FX Hulu (Wikipedia)
AC A Christmas Carol by Charles Dickens (Wikipedia) and The Muppet Christmas Carol (Wikipedia)
Anna Monty Don (Wikipedia)
Nayan Back Street Boys at The Sphere (Wikipedia)
Brian Marty Supreme (Wikipedia)
Cristina The Yellow Tie (Wikipedia)
Vipin Stranger Things, good for a four year old? (Wikipedia)
Joel Crash Course: The Universe with Katie Mack and John Green (Apple PodCasts)