Health Optimization Medicine Podcast

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia.
Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time.
Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more.
Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience.
Join us as we delve into:
What microglia are and why they control brain health
The difference between M1 (destructive) and M2 (protective) states
How metabolism shapes the brain's immune response
Why conditions like Alzheimer's are rooted in immune dysfunction
The connection between blood sugar, insulin, and brain degeneration
This episode is for you if:
You want to protect your brain and prevent cognitive decline
You're interested in the science of Alzheimer's and neurodegeneration
You want actionable strategies to improve brain health
You're curious about the future of brain optimization and longevity
You can also find this episode on… Youtube: https://youtu.be/EMrlchMOZKk
Find more from Dr. David Perlmutter Website: https://www.drperlmutter.com Book: https://braindefenders.com LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/ Instagram: https://www.instagram.com/davidperlmutter/ Facebook: https://www.facebook.com/DavidPerlmutterMd/
Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics
Find more from Troscriptions Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval as they explore chronobiology — and how modern life is disrupting the body's natural rhythms.
From jet lag and shift work to late-night scrolling and irregular meals, the conversation dives into what Dr. Ted calls "circadian pollution" — the mismatch between our biology and the environments we've created.
More importantly, the team breaks down simple, powerful tools to re-entrain your body clock using light, food timing, and movement — all foundational principles in Health Optimization Medicine.
Join us as we delve into:
What chronobiological re-entrainment actually means
The difference between the brain clock and organ clocks
How light, food, and movement act as biological time signals
Why late-night eating creates "metabolic jet lag"
How modern life creates circadian disruption
This episode is for you if:
You struggle with sleep, fatigue, or inconsistent energy
You travel frequently or work irregular hours
You want to optimize your circadian rhythm naturally
You're looking for simple, zero-cost ways to improve health
You can also find this episode on… 
YouTube: https://youtu.be/WcheAJNzq2k
Find more from Health Optimization Medicine and Practice (HOMeHOPe):
Website: https://homehope.org/
Instagram: https://www.instagram.com/homehopeorg/
Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026
Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics
Find more from Troscriptions:
Website: https://troscriptions.com/
Instagram: https://www.instagram.com/troscriptions/
Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products

In this episode of the Health Optimization Medicine Podcast, join Boomer Anderson, Jodi Duval, Dr. Allen Bookatz, and Dr. Ted Achacoso as they explore the future of clinical intelligence — and why medicine must move beyond single biomarkers to understanding networks within the body.
Rather than chasing isolated lab values like glucose, cholesterol, or testosterone, the conversation shifts toward a systems-based approach — where every biomarker is part of a dynamic network of relationships.
From metabolomics to hormone balance, this episode explains why optimizing health requires understanding how different systems interact, adapt, and influence each other in real time.
Join us as we delve into:
Why single biomarkers are only "nodes" in a larger biological network
The concept of nodes and edges in human physiology
How glucose, thyroid, and metabolic systems are interconnected
Why cholesterol, inflammation, and B vitamins must be viewed together
The risks of optimizing one biomarker (like testosterone) in isolation
This episode is for you if:
You've been told to "fix" a single lab value but still feel off
You want to understand your lab results in a deeper, systems-based way
You're a practitioner looking to move beyond reductionist medicine
You're interested in metabolomics and the future of health optimization
You can also find this episode on…
Youtube: https://youtu.be/CMbdZEnnuGo
Find more from Health Optimization Medicine and Practice (HOMeHOPe):
Website: https://homehope.org/
Instagram: https://www.instagram.com/homehopeorg/
Virtual Symposium 2026:https://homehope.org/homehope-virtual-symposium-2026
Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://www.homehope.org/
Find more from Troscriptions:
Website: https://troscriptions.com/
Instagram: https://www.instagram.com/troscriptions/
Use POD10 to get 10% OFF your Troscriptions purchase at https://www.troscriptions.com/

In this episode of the Health Optimization Medicine Podcast, join Dr. Scott Sherr, Dr. Ted Achacoso, Dr. Allen Bookatz, and Jodi Duval as they explore the hidden cost of convenience and comfort in modern life.
 
From ultra-processed foods and low-fiber diets to sedentary lifestyles and technology-driven comfort, the conversation dives into how convenience is quietly reshaping our biology. The HOMeHOPe Faculty explains why small daily habits — like eating whole foods, moving regularly, and embracing mild discomfort — are essential for maintaining cellular health and resilience.
 
Rather than trying to "hack" health with quick fixes, the discussion emphasizes consistent lifestyle behaviors that support the microbiome, metabolic function, and long-term health optimization.
 
Join us as we delve into:
• Why fiber is the fastest disappearing macronutrient in modern diets
• The role of gut microbiota and short-chain fatty acids in health
• Why habits like sleep, eating, and exercise cannot be "banked"
• The physiological consequences of ultra-convenient lifestyles
• Practical ways to introduce beneficial stress back into daily life
 
This episode is for you if:
• You want to understand how convenience affects human physiology
• You're interested in the role of fiber and gut health in disease prevention
• You want practical ways to improve resilience and metabolic health
• You're curious about the philosophy behind Health Optimization Medicine
 
You can also find this episode on…
YouTube: https://youtu.be/6wLPUuLQgcY
 
Find more from Health Optimization Medicine and Practice (HOMeHOPe):
Website: https://homehope.org/
Instagram: https://www.instagram.com/homehopeorg/
Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026
Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://www.homehope.org/
 
Find more from Troscriptions:
Website: https://troscriptions.com/
Instagram: https://www.instagram.com/troscriptions/
Use POD10 to get 10% OFF your Troscriptions purchase at https://www.troscriptions.com/

In this episode of the Health Optimization Medicine Podcast, the HOMeHOPe Faculty comes together for a roundtable conversation exploring the core philosophical framework behind Health Optimization Medicine.
Dr. Scott Sherr, Boomer Anderson, and Dr. Allen Bookatz break down the three fundamental perspective shifts that redefine how we think about health, disease, aging, and the human body itself. Rather than focusing on disease management, this episode introduces the foundational principles behind building health from the cellular level up.
Join us as we delve into: • The shift from pathogenesis (studying disease) to salutogenesis (creating health) • Why longevity alone isn't enough without vitality and morbidity compression • How neotenization focuses on restoring youthful biological function • The concept of the holobiont: humans as ecosystems of interconnected organisms
This episode is for you if: • You want to understand the philosophy behind Health Optimization Medicine • You're curious why modern healthcare focuses on disease instead of health • You're interested in metabolomics, cellular health, and systems biology • You want a deeper framework for longevity, vitality, and resilience
You can also find this episode on… Youtube: https://youtu.be/wuCXmT783_o
Find more from Health Optimization Medicine and Practice (HOMeHOPe): Website: https://homehope.org/ Instagram: https://www.instagram.com/homehopeorg/ Virtual Symposium 2026:https://homehope.org/homehope-virtual-symposium-2026 Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://www.homehope.org/
Find more from Troscriptions: Website: https://troscriptions.com/ Instagram: https://www.instagram.com/troscriptions/ Use POD10 to get 10% OFF your Troscriptions purchase at https://www.troscriptions.com/