Episode 11. Do Statins Influence The Risk of Dementia?
In today’s episode, we’ll be discussing one of the most frequently discussed, and often debated, topics in preventive medicine, do statins influence the risk of dementia? You’ve probably heard some express concern that statins can cause memory loss or increase the risk of dementia, whereas others may emphasize the ability of statins to protect brain health. So what does the science really say? In this episode, we’ll explore the role of cholesterol in normal brain health, theoretical mechanisms explaining how statin therapy may cause harm as well as potential neurologic protection transition to review high quality evidence from randomized clinical trial, mendelian randomization, and even studies investigating those with genetic abnormalities resulting is exceedingly low levels of LDL throughout their lifetime genetic studies. And then most importantly, how this translates into practical decisions for those seeking to promote longevity and reduce their likelihood of dementia.Blog Post and References:https://kevinforeymd.com/statins-dementia/
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Episode 10. Beyond LDL: Why Remnant Cholesterol Deserves More Attention
In today’s episode, we will be diving into the topic of remnant cholesterol, a largely unknown and underappreciated risk factor of cardiovascular disease. Not only does remnant cholesterol contribute to heart attack, stroke, and peripheral artery disease, it is now recognized as an independent risk factor of atherosclerosis, even when LDL-C and ApoB levels are considered optimal. In other words, having "good" ApoB and LDL cholesterol numbers doesn't eliminate the possibility of atherosclerosis, where remnant cholesterol is now recognized to account for a meaningful amount of this "residual risk." Even more intriguing is the mounting body of research that suggests that remnant cholesterol may actually be a stronger predictor of cardiovascular disease than LDL-C itself, yet very few people are even aware it exists. Not only am I excited to share this topic with you today, but I’m also excited to share what you can do about it.Blog Post and References:http://kevinforeymd.com/remnantcholesterol
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Episode 9. Insulin Resistance: A Protocol for Prevention, Early Detection, and Reversal
In today’s episode, I will be discussing a comprehensive overview of advanced testing and early identification of insulin resistance, but more importantly, evidence-based strategies to prevent and reverse insulin resistance. We will have an in-depth analysis of the comparative effectiveness of food and nutrition, aerobic exercise at moderate and high intensity heart rate zones, and strength training. We will also look into the effect of sleep duration, sleep quality, sleep fragmentation, and psychological health and their relationship to insulin resistance. Additionally, we will touch upon commonly utilized supplements and medications for overcoming insulin resistance and type 2 diabetes. Blog Post and References:http://kevinforeymd.com/insulinresistance
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Episode 8. Why LDL-C, Hemoglobin A1c, and Continuous Glucose Monitors Are Not Optimal Tests For Longevity
In today’s episode, we will be discussing the shortcomings and alternatives to some of the most commonly utilized tests for longevity and preventive medicine, including LDL cholesterol (LDL-C), Hemoglobin A1c (HbA1c), and Continuous Glucose Monitors (CGMs). With advancements in technology, there are now multiple laboratory tests that provide more accurate and useful information than LDL-C, HbA1c, or CGMs. Despite these improvements in testing, widespread awareness and adoption of these superior tests remain limited. The purpose of this podcast is to demonstrate the shortcomings of LDL-C, HbA1c, and CGMs. By examining alternative testing strategies, this podcast seeks to empower health conscious individuals and healthcare professionals in their ability to adopt more effective testing strategies for the prevention of disease and promotion of longevity. In summary,a normal LDL-C does not rule out the risk of cardiovascular disease, and thatnormal results from HbA1c and CGM data do not rule out the possibility of insulin resistance. Meanwhile, there are more effective testing strategies available to those who are seeking to optimize their health, likelihood of longevity, and ability to identify disease risk as early as possible.Link toOriginal Blog Post andReferences.Link toLPIR Score.Link toTriglyceride-Glucose Index (TyG Index).Link toHOMA-IR Calculator.
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Episode 7. How To Reverse Atherosclerosis: Strategies For Those With a Positive Coronary Artery Calcium (CAC) Score
In this podcast episode we will review the evidence demonstrating the variety of strategies capable of achieving partial reversal and regression of atherosclerosis in the human body, including aerobic exercise, the targeted lowering of atherogenic lipoproteins including LDL-C and Apolipoprotein-B (ApoB), the use of Icosapent Ethyl (Vascepa) in those with and without elevated triglycerides, blood pressure lowering agents including Angiotensin Receptor Blockers (ARBs), glucose-lowering agents such as Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors, and medications with anti-inflammatory properties, including Colchicine. Additionally, we will review the preliminary data regarding atherosclerotic plaque regression and Glucagon-like Peptide 1 (GLP-1) Receptor Agonists.
References:
https://kevinforeymd.com/reverseASCVD/
Kevin Forey MD seeks to provide an educational resource for everyday individuals who are interested in learning more about food, nutrition, physical exercise, and other strategies for preventing common medical illnesses. Throughout this podcast, you will find an unbiased and evidence-based message that is easy to understand.
https://www.kevinforeymd.com/
Ireland